Lazy eye study tests best order for glasses and patching
NCT ID NCT04378790
First seen Nov 01, 2025
Summary
This study looks at the best way to treat lazy eye (amblyopia) in children aged 3 to under 13. Some children get glasses and an eye patch at the same time, while others start with glasses alone and add patching later if needed. The goal is to see if both approaches lead to similar vision improvement. About 544 children will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Akron Children's Hospital
RECRUITINGAkron, Ohio, 44308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Arizonia Pediatric Eye Specialists
RECRUITINGPhoenix, Arizona, 85006, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
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Boston Children's Hospital Waltham
RECRUITINGBoston, Massachusetts, 02453, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Casey Eye Institute
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Los Angeles (CHLA)
RECRUITINGLos Angeles, California, 90027, United States
Contact Email: •••••@•••••
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cincinnati Children's Hospital
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Conestoga Eye
RECRUITINGLancaster, Pennsylvania, 17601, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Corewell Health
RECRUITINGGrand Rapids, Michigan, 49503, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dean A. McGee Eye Institute
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Email: •••••@•••••
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Duke University Eye Center
RECRUITINGDurham, North Carolina, 27710, United States
Contact Email: •••••@•••••
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Eye Physicians & Surgeons, PC
RECRUITINGMilford, Connecticut, 06460, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana School of Optometry
RECRUITINGBloomington, Indiana, 47405, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana University School of Optometry
RECRUITINGIndianapolis, Indiana, 47405, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Loma Linda University Health Care, Dept. of Ophthalmology
RECRUITINGLoma Linda, California, 92354, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Marshall B. Ketchum University
RECRUITINGFullerton, California, 92831, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
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Midwestern U Chicago College of Optometry
RECRUITINGDowners Grove, Illinois, 60515, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Midwestern University Eye Institute
RECRUITINGGlendale, Arizona, 85308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NYU Langone Health
RECRUITINGNew York, New York, 10017, United States
Contact Email: •••••@•••••
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Nemours Children's Clinic
RECRUITINGJacksonville, Florida, 32207, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nova Southeastern University College of Optometry, The Eye Institute
RECRUITINGFort Lauderdale, Florida, 33382, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University College of Optometry
RECRUITINGColumbus, Ohio, 43210-1280, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pediatric Eye Specialists, LLP
RECRUITINGFort Worth, Texas, 76014, United States
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Pediatric Ophthalmology of Erie
RECRUITINGErie, Pennsylvania, 16501, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pediatric Ophthalmology, P.C.
RECRUITINGGrand Rapids, Michigan, 49546, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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PineCone Vision Center
RECRUITINGSartell, Minnesota, 56377, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Prisma Health
RECRUITINGColumbia, South Carolina, 29203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Progressive Eye Care
RECRUITINGLisle, Illinois, 60532, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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River View Family Eyecare
RECRUITINGAlbany, Oregon, 97321, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rocky Mountain Eye Care Associates
RECRUITINGSalt Lake City, Utah, 84107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ross Eye Institute, University of Buffalo, Med School Dept Ophthalmology
RECRUITINGBuffalo, New York, 14209, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Salus University/Pennsylvania College of Optometry
RECRUITINGPhiladelphia, Pennsylvania, 19141, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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San Antonio Eye Center
RECRUITINGSan Antonio, Texas, 78215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seattle Children's Hospital, University of Washington
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Snowy Range Vision Center
RECRUITINGLaramie, Wyoming, 82070, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Southern College of Optometry
RECRUITINGMemphis, Tennessee, 38104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Spokane Eye Clinical Research
RECRUITINGSpokane, Washington, 99204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St Luke's Hospital
RECRUITINGBoise, Idaho, 83702, United States
Contact Email: •••••@•••••
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St. Louis Children's Hospital Eye Center
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University
RECRUITINGPalo Alto, California, 94303, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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State University of New York, College of Optometry
RECRUITINGNew York, New York, 10036, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Tech University Health Science Center
RECRUITINGLubbock, Texas, 79430, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ticho Eye Associates
RECRUITINGChicago Ridge, Illinois, 60415, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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U of MO St. Louis College of Optometry
RECRUITINGSt Louis, Missouri, 63121, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UAB Pediatric Eye Care; Birmingham Health Care
RECRUITINGBirmingham, Alabama, 35294, United States
Contact
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UPMC Children's Eye Center of Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Univ of California, Irvine- Gavin Herbert Eye Institute
RECRUITINGIrvine, California, 92697, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Univ. of California- Berkeley
RECRUITINGBerkeley, California, 94720, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Arizona
RECRUITINGTucson, Arizona, 85711, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco Department of Ophthalmology
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, Davis
RECRUITINGSacramento, California, 95817, United States
Contact Email: •••••@•••••
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University of Incarnate Word Rosenberg School of Optometry
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68114, United States
Contact Email: •••••@•••••
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University of North Carolina
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of South Florida (USF) Eye
RECRUITINGTampa, Florida, 33620, United States
Contact Email: •••••@•••••
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University of the Incarnate Word
RECRUITINGSan Antonio, Texas, 78209, United States
Contact Email: •••••@•••••
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Vanderbilt University Medical Center - Vanderbilt Eye Institute
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Pediatric Eye Center
RECRUITINGNorfolk, Virginia, 23502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Western University College of Optometry
RECRUITINGPomona, California, 91766, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wills Eye Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wilmer Eye Institute
RECRUITINGBaltimore, Maryland, 21287-9028, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wolfe Eye Clinic
RECRUITINGWest Des Moines, Iowa, 50266, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zenith Vision Development Center
RECRUITINGDuluth, Minnesota, 55811, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Glasses and eye patch
What this could lead to
If successful, this could show that starting both treatments at once is just as effective, potentially simplifying care for children with lazy eye.
What could go wrong
This is a large phase 3 trial, but it compares timing of existing treatments, not a new cure. Results may not apply to all types of amblyopia.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.