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Eye implant could reduce need for frequent shots for blinding disease

NCT ID NCT03683251

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 01, 2026 · Updated 5 times

Summary

This study is checking the long-term safety of a small implant placed in the eye that slowly releases medicine to treat wet age-related macular degeneration, a condition that can cause rapid vision loss. About 1,000 people who have already used the implant in earlier studies will be followed for several years. The goal is to see if the implant is safe and works well over time, possibly reducing the need for frequent eye injections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2018

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previous enrollment in and completion of Study GX28228 (Ladder) or Study GR40548 (Archway), without early treatment or study discontinuation in either study OR Previous enrollment in Study WR42221 (Velodrome) and either not eligible to be randomized in Study WR42221 at Week 24 or completed the study (from the Q24W or Q36W arm) * Ability and willingness to undertake all scheduled visits and assessments * For women of childbearing potential: agreement to remain abstinent or use contraceptive measures Exclusion Criteria: * Pregnant or breastfeeding, or intending to become pregnant during the treatment period and for at least 28 days after the last intravitreal injection of ranibizumab or 1 year after the last Implant refill-exchange of ranibizumab * History of other ocular diseases that give reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab, that might affect interpretation of the results of the study or that renders the participant at high risk for treatment complications * History of other diseases, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab or placement of the Implant and that might affect interpretation of the results of the study or that renders the participant at high risk of treatment complications * Requirement for continuous use of any medications or treatments indicated in the "Prohibited Therapy" Sub-study 1 Inclusion Criteria \- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures Participants must meet the following ocular criteria for the study eye for substudy entry: * Diagnosis of exudative nAMD within 2 years prior to the enrollment visit * Previous treatment with at least two anti-VEGF ITV injections (e.g., ranibizumab, bevacizumab, or aflibercept) for nAMD per standard of care within 6 months prior to the enrollment visit * Demonstrated response to prior anti-VEGF ITV treatment since diagnosis, as evidenced at enrollment by the following: Overall decrease in nAMD disease activity detected on SD-OCT AND Stable or improved best-corrected visual acuity (BCVA) * All subtypes of nAMD lesions are permissible (i.e., type I, type II, type III, or mixed forms per optical coherence tomography (OCT) classification) nAMD lesions at the time of diagnosis must involve the macula (6 mm diameter centered at the fovea). * Sufficiently clear ocular media and adequate pupillary dilation to allow for analysis and grading by the central reading center of FP and SD-OCT images. Exclusion Criteria Prior Ocular Treatments Study Eye * History of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD * Prior treatment with Visudyne, external-beam radiation therapy, or transpupillary thermotherapy * Previous treatment with corticosteroid ITV injection * Previous intraocular device implantation * Previous laser (any type) used for AMD treatment Either Eye * Treatment with anti-VEGF agents other than ranibizumab within 1 month prior to the enrollment visit * Prior participation in a clinical trial involving anti-VEGF drugs within 6 months prior to the enrollment visit, other than ranibizumab CNV Lesion Charateristics Study Eye * Subretinal hemorrhage that involves the center of the fovea, if the hemorrhage is greater than 0.5 disc area (1.27 mm2 ) in size at screening * Subfoveal fibrosis or subfoveal atrophy Either Eye \- CNV due to other causes, such as ocular histoplasmosis, trauma, or pathologic myopia Concurrent Ocular Conditions Study Eye * Retinal pigment epithelial tear * Any concurrent intraocular condition (e.g., cataract, glaucoma, diabetic retinopathy, or epiretinal membrane) that would either require surgical intervention during the study to prevent or treat visual loss that might result from that condition or affect interpretation of study results * Active intraocular inflammation (grade trace or above) * History of vitreous hemorrhage * History of rhegmatogenous retinal detachment * History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 months prior to the enrollment visit * Aphakia or absence of the posterior capsule * Previous violation of the posterior capsule is also an exclusion criterion unless it occurred as a result of yttrium-aluminum garnet (YAG) laser posterior capsulotomy in association with prior, posterior chamber intraocular lens implantation. * Spherical equivalent of the refractive error demonstrating more than 8 diopters of myopia * Preoperative refractive error that exceeds 8 diopters of myopia, for participants who have undergone prior refractive or cataract surgery in the study eye * Intraocular surgery (including cataract surgery) within 3 months preceding the enrollment visit * Uncontrolled ocular hypertension or glaucoma and any such condition the investigator determines may require a glaucoma-filtering surgery during a patient's participation in the study * History of glaucoma-filtering surgery, tube shunts, or microinvasive glaucoma surgery * History of corneal transplant * History of prior vitrectomy surgery and absence of posterior capsule Either Eye * History of idiopathic or autoimmune-associated uveitis * Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis Concurrent Systemic Conditions * Inability to comply with study schedule or procedures as described in the study protocol * Uncontrolled blood pressure * History of stroke within the last 3 months prior to informed consent * Uncontrolled atrial fibrillation within 3 months of informed consent * History of myocardial infarction within the last 3 months prior to informed consent * History of other disease, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab or placement of the implant and that might affect interpretation of the results of the study or renders the patient at high risk of treatment complications in the opinion of the investigator * Current systemic treatment for a confirmed active systemic infection * Use of any systemic anti-VEGF agents * Chronic use of oral corticosteroids * Active cancer within 12 months of enrollment * Previous participation in any non-ocular (systemic) disease studies of investigational drugs within 1 month preceding the informed consent (excluding vitamins and minerals) * Use of antimitotic or antimetabolite therapy within 30 days or 5 elimination half-lives of the enrollment visit * History of albinism * Pregnant or breastfeeding, or intending to become pregnant during the treatment period and for at least 28 days after the last ITV injection of ranibizumab or 1 year after the last implant refill-exchange of ranibizumab Sub-study 2 Inclusion Criteria: * Having experienced septum dislodgement in the original implant while in the main study or after exiting the main study Ocular Inclusion Criteria for Study Eye * Sufficiently clear ocular media and adequate pupillary dilation to allow for analysis and grading by central reading center Exclusion Criteria (Cohort 1 only): Concurrent Ocular Conditions-Study Eye * Any ocular condition that may render the patient at high risk for surgical or treatment complications * Intraocular surgery (including cataract surgery) within 1 month preceding the enrollment visit * Any use of medicated intraocular implants (other than the PDS implant), at any time prior to enrollment * History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 months prior to the enrollment visit * Any concurrent ocular condition that would require surgical intervention during the study to prevent or treat visual loss * Concurrent conjunctival, Tenon's capsule, and/or scleral condition in the supero-temporal quadrant of the eye (e.g., scarring, thinning, mass) that may affect the refill-exchange procedure of the PDS implant * Ongoing ocular complications that might affect participant safety Concurrent Ocular Conditions-Either Eye * Suspected or active ocular or periocular infection * Any history of uveitis * Active blepharitis Concurrent Systemic Conditions * Recent history (in the last 3 months prior to enrollment) of other disease, other non-diabetic metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a condition that contraindicates the use of ranibizumab or surgical placement of the PDS implant; that might affect interpretation of the results of the study; or that renders the participant at high risk for treatment complications * Active cancer within the last 12 months, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, or prostate cancer * Current systemic treatment for a confirmed active systemic infection - Participation in an investigational trial that involves treatment with any drug or device (with the exception of vitamins and minerals or enrollment in the main study GR40549) within 6 months prior to enrollment. * Use of antimitotic or antimetabolite therapy within 30 days or 5 elimination half-lives.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neovascular age-related macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    75 sites in 13 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A.O. Universitaria S. Maria Della Misericordia Di Udine

    RECRUITING

    Udine, Veneto, 33100, Italy

  • Ankara Bilkent City Hospital

    RECRUITING

    Ankara, 06490, Turkey (Türkiye)

  • Ankara Etlik City Hospital

    RECRUITING

    Ankara, DUMMY_VALUE, Turkey (Türkiye)

  • Arizona Retina and Vitreous Consultants

    COMPLETED

    Phoenix, Arizona, 85016, United States

  • Associated Retina Consultants

    COMPLETED

    Phoenix, Arizona, 85020, United States

  • Associated Retinal Consultants

    COMPLETED

    Royal Oak, Michigan, 48073, United States

  • Asst Fatebenefratelli Sacco

    RECRUITING

    Milan, Lombardy, 20157, Italy

  • Augenabteilung am St. Franziskus-Hospital

    RECRUITING

    Münster, 48145, Germany

  • Austin Clinical Research LLC

    ACTIVE_NOT_RECRUITING

    Austin, Texas, 78750, United States

  • Austin Retina Associates

    COMPLETED

    Austin, Texas, 78705, United States

  • Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia

    RECRUITING

    Perugia, Umbria, 06129, Italy

  • Azienda Ospedaliero Universitaria "Ospedali Riuniti" Trieste-Ospedale Maggiore

    RECRUITING

    Trieste, Friuli Venezia Giulia, 34129, Italy

  • Azienda Ospedaliero Universitaria Ospedali Riuniti

    RECRUITING

    Torrette - Ancona, The Marches, 60126, Italy

  • Azienda Ospedaliero-Universitaria Careggi

    RECRUITING

    Florence, Tuscany, 50134, Italy

  • Barnet Dulaney Perkins Eye Center

    ACTIVE_NOT_RECRUITING

    Phoenix, Arizona, 85016, United States

  • Beyoglu Goz Training and Research Hospital

    RECRUITING

    Istanbul, 34421, Turkey (Türkiye)

  • Botelho Hospital da Visao

    RECRUITING

    Blumenau, Santa Catarina, 89052-504, Brazil

  • Bristol Eye Hospital

    RECRUITING

    Bristol, BS1 2LX, United Kingdom

  • California Retina Consultants

    COMPLETED

    Bakersfield, California, 93309, United States

  • California Retina Consultants

    COMPLETED

    Santa Barbara, California, 93103, United States

  • Central Middlesex Hospital

    RECRUITING

    London, NW10 7NS, United Kingdom

  • Centre Paradis Monticelli

    RECRUITING

    Marseille, 13008, France

  • Centre Retine Gallien

    RECRUITING

    Bordeaux, 33000, France

  • Centro Oftalmologico Dr. Charles S.A.

    RECRUITING

    Ciudad Autonoma Buenos Aires, C1121ABB, Argentina

  • Centro de Oftalmologia Barraquer

    RECRUITING

    Barcelona, 08021, Spain

  • Chang Gung Medical Foundation - Linkou

    RECRUITING

    Taoyuan, 333, Taiwan

  • Changhua Christian Hospital

    RECRUITING

    Changhua, 500, Taiwan

  • Char Eye Ear &Throat Assoc

    COMPLETED

    Charlotte, North Carolina, 28210, United States

  • Charles Retina Institute

    COMPLETED

    Germantown, Tennessee, 38138, United States

  • Cincinnati Eye Institute

    ACTIVE_NOT_RECRUITING

    Cincinnati, Ohio, 45242, United States

  • Clinica Baviera

    RECRUITING

    Madrid, 28046, Spain

  • Clinica Universitaria de Navarra

    RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Colorado Retina Associates, PC

    COMPLETED

    Lakewood, Colorado, 80228, United States

  • Envision Ocular, LLC

    COMPLETED

    Bloomfield, New Jersey, 07003, United States

  • Eye Center of Northern CO

    COMPLETED

    Fort Collins, Colorado, 80528, United States

  • Eye and Retina Consultants

    RECRUITING

    Hurstville, New South Wales, 2220, Australia

  • Eyeclinic Albury Wodonga

    ACTIVE_NOT_RECRUITING

    Albury, New South Wales, 2640, Australia

  • Florida Eye Associates

    COMPLETED

    Melbourne, Florida, 32901, United States

  • Florida Eye Microsurgical Inst

    COMPLETED

    Boynton Beach, Florida, 33426, United States

  • Fondation Asile Des Aveugles ? Jules Gonin Eye Hospital

    RECRUITING

    Lausanne, Switzerland

  • Fondation Rothschild

    RECRUITING

    Paris, 75940, France

  • Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico

    RECRUITING

    Rome, Lazio, 00198, Italy

  • Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena

    RECRUITING

    Milan, Lombardy, 20100, Italy

  • Fort Lauderdale Eye Institute

    COMPLETED

    Plantation, Florida, 33324, United States

  • Foundation for Vision Research

    COMPLETED

    Grand Rapids, Michigan, 49546, United States

  • Georgia Retina PC

    WITHDRAWN

    Marietta, Georgia, 30060, United States

  • Grupo Laser Vision

    RECRUITING

    Rosario, S2000DLA, Argentina

  • Hacettepe University Medical Faculty

    RECRUITING

    Ankara, 06100, Turkey (Türkiye)

  • Hadassah MC

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hopital Lariboisiere

    RECRUITING

    Paris, 75010, France

  • Hopital de la croix rousse

    RECRUITING

    Lyon, 69317, France

  • Hosp de Olhos de Sorocaba

    RECRUITING

    Sorocaba, São Paulo, 18031-060, Brazil

  • Hospital General de Catalunya

    RECRUITING

    San Cugat Del Valles, Barcelona, 08195, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Puerta de Hierro

    RECRUITING

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario de Bellvitge

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital de la Arruzafa. Servicio de Oftalmologia

    RECRUITING

    Córdoba, 14012, Spain

  • Hospital dos de maig

    COMPLETED

    Barcelona, 08025, Spain

  • Illinois Retina Associates

    COMPLETED

    Joliet, Illinois, 60435, United States

  • Inselspital Bern Ophthalmologische Klinik

    RECRUITING

    Bern, 3010, Switzerland

  • Institut de la Macula i la retina

    RECRUITING

    Barcelona, 08022, Spain

  • Instituto Oftalmologico Fernandez Vega

    RECRUITING

    Oviedo, Principality of Asturias, 33012, Spain

  • Instituto da Visao IPEPO

    RECRUITING

    São Paulo, São Paulo, 04038-032, Brazil

  • Irccs Ospedale San Raffaele

    RECRUITING

    Milan, Lombardy, 20132, Italy

  • Jacobs Retina center at the Shiley eye Institute UCSD

    COMPLETED

    La Jolla, California, 92037, United States

  • Johns Hopkins Med

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21287, United States

  • Jules Stein Eye Institute/ UCLA

    COMPLETED

    Los Angeles, California, 90095-7000, United States

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, Taiwan

  • Kaplan Medical Center

    RECRUITING

    Rehovot, 7660101, Israel

  • Kings College Hospital NHS Foundation Trust

    ACTIVE_NOT_RECRUITING

    London, SE5 9RS, United Kingdom

  • Klinikum der Stadt Ludwigshafen am Rhein gGmbH

    RECRUITING

    Ludwigshafen, 67063, Germany

  • Knappschaftsklinikum Saar GmbH

    RECRUITING

    Sulzbach, 66280, Germany

  • Kocaeli University Medical Faculty

    RECRUITING

    Kocaeli, 41380, Turkey (Türkiye)

  • LKH-Univ.Klinikum Graz

    RECRUITING

    Graz, 8036, Austria

  • LMU Klinikum der Universitat, Augenklinik

    RECRUITING

    München, 80336, Germany

  • Long Is. Vitreoretinal Consult

    COMPLETED

    Great Neck, New York, 11021, United States

  • Maine Eye Center

    COMPLETED

    Portland, Maine, 04101, United States

  • Med Center Ophthalmology Assoc

    COMPLETED

    San Antonio, Texas, 78240, United States

  • Medizinische Universitat Lausitz ? Carl Thiem

    RECRUITING

    Cottbus, 03048, Germany

  • Medizinische Universitat Wien

    RECRUITING

    Vienna, 1090, Austria

  • Meir Medical Center

    RECRUITING

    Kfar Saba, 4428164, Israel

  • Mid Atlantic Retina - Wills Eye Hospital

    COMPLETED

    Philadelphia, Pennsylvania, 19107, United States

  • Midwest Vision Research Foundation

    COMPLETED

    Chesterfield, Missouri, 63017, United States

  • Moorfields Eye Hospital NHS Foundation Trust

    ACTIVE_NOT_RECRUITING

    London, EC1V 2PD, United Kingdom

  • N CA Retina Vitreous Assoc

    COMPLETED

    Mountain View, California, 94040, United States

  • National Ophthalmic Research Institute

    COMPLETED

    Fort Myers, Florida, 33912, United States

  • National Taiwan University Hospital

    RECRUITING

    Zhongzheng Dist., 10002, Taiwan

  • OSU Eye Physicians & Surgeons

    ACTIVE_NOT_RECRUITING

    Columbus, Ohio, 43212, United States

  • Oftalmos

    RECRUITING

    Capital Federal, C1120AAN, Argentina

  • Oftalvist Valencia

    RECRUITING

    Burjassot, Valencia, 46100, Spain

  • Ophthalmic Consultants of Boston

    COMPLETED

    Boston, Massachusetts, 02114, United States

  • Ophthalmic Consultants of Long Island

    COMPLETED

    Rockville Centre, New York, 11570, United States

  • Orange County Retina Med Group

    ACTIVE_NOT_RECRUITING

    Santa Ana, California, 92705, United States

  • Oregon HSU

    COMPLETED

    Portland, Oregon, 97239, United States

  • Ospedale Classificato Equiparato Sacro Cuore ? Don Calabria

    RECRUITING

    Negrar - Verona, Veneto, 37024, Italy

  • Ospedale Clinicizzato SS Annunziata

    RECRUITING

    Chieti, Abruzzo, 66100, Italy

  • Pacific Northwest Retina

    COMPLETED

    Silverdale, Washington, 98383, United States

  • Paducah Retinal Center

    WITHDRAWN

    Paducah, Kentucky, 42001, United States

  • Palmetto Retina Center

    COMPLETED

    Florence, South Carolina, 29501, United States

  • Palmetto Retina Center, LLC

    COMPLETED

    West Columbia, South Carolina, 29169, United States

  • Policlinico Universitario Agostino Gemelli

    RECRUITING

    Rome, Lazio, 00168, Italy

  • Policlinico di Bari

    RECRUITING

    Bari, Apulia, 70124, Italy

  • Rabin MC

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Rambam Medical Center

    RECRUITING

    Haifa, 3109601, Israel

  • Retina Assoc of Western NY

    COMPLETED

    Rochester, New York, 14620, United States

  • Retina Associates

    COMPLETED

    Lenexa, Kansas, 66215, United States

  • Retina Associates of Florida, LLC

    COMPLETED

    Tampa, Florida, 33609, United States

  • Retina Associates of Kentucky

    COMPLETED

    Lexington, Kentucky, 40509, United States

  • Retina Associates of NJ

    COMPLETED

    Teaneck, New Jersey, 07666, United States

  • Retina Associates of Utah, PLLC

    COMPLETED

    Salt Lake City, Utah, 84107, United States

  • Retina Care Specialists

    COMPLETED

    Palm Beach Gardens, Florida, 33410, United States

  • Retina Clinic

    RECRUITING

    São Paulo, São Paulo, 01427-002, Brazil

  • Retina Consultants of Texas

    COMPLETED

    Bellaire, Texas, 77401, United States

  • Retina Consultants of Texas

    COMPLETED

    The Woodlands, Texas, 77384, United States

  • Retina Consultants, San Diego

    COMPLETED

    Poway, California, 92064, United States

  • Retina Group of New England

    COMPLETED

    Waterford, Connecticut, 06385, United States

  • Retina Group of Washington

    COMPLETED

    Chevy Chase, Maryland, 20815, United States

  • Retina Northwest

    COMPLETED

    Portland, Oregon, 97221, United States

  • Retina Specialists

    COMPLETED

    Towson, Maryland, 21204, United States

  • Retina Specialty Institute

    COMPLETED

    Pensacola, Florida, 32503, United States

  • Retina Vit Surgeons/Central NY

    COMPLETED

    Syracuse, New York, 13224, United States

  • Retina Vitreous Assoc of FL

    ACTIVE_NOT_RECRUITING

    St. Petersburg, Florida, 33711, United States

  • Retina Vitreous Center

    COMPLETED

    Edmond, Oklahoma, 73013, United States

  • Retina-Vitreous Associates Medical Group

    COMPLETED

    Beverly Hills, California, 90211, United States

  • Retinal Consultants Med Group

    COMPLETED

    Sacramento, California, 95841, United States

  • Retinal Consultants of Arizona

    COMPLETED

    Phoenix, Arizona, 85053, United States

  • Retinal Research Institute, LLC

    COMPLETED

    Phoenix, Arizona, 85014, United States

  • Rocky Mountain Retina

    COMPLETED

    Salt Lake City, Utah, 84107, United States

  • Royal Liverpool University Hospital

    ACTIVE_NOT_RECRUITING

    Liverpool, L7 8XP, United Kingdom

  • Royal Victoria Infirmary

    RECRUITING

    Newcastle upon Tyne, NE1 4LP, United Kingdom

  • Royal Wolverhampton hospital

    RECRUITING

    Wolverhampton, WV10 0QP, United Kingdom

  • Sierra Eye Associates

    ACTIVE_NOT_RECRUITING

    Reno, Nevada, 89502, United States

  • Southeast Retina Center

    COMPLETED

    Augusta, Georgia, 30909, United States

  • Southern Vitreoretinal Assoc

    ACTIVE_NOT_RECRUITING

    Tallahassee, Florida, 32308, United States

  • Southwest Retina Consultants

    COMPLETED

    Durango, Colorado, 81303, United States

  • Spokane Eye Clinical Research

    COMPLETED

    Spokane, Washington, 99204, United States

  • Stadtspital Triemli Ophthalmologische Klinik

    ACTIVE_NOT_RECRUITING

    Zurich, 8063, Switzerland

  • Sunderland Eye Infirmary

    ACTIVE_NOT_RECRUITING

    Sunderland, SR2 9HP, United Kingdom

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • Tel Aviv Sourasky MC

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Tennessee Retina PC

    ACTIVE_NOT_RECRUITING

    Nashville, Tennessee, 37203, United States

  • Texas Retina Associates

    COMPLETED

    Arlington, Texas, 76012, United States

  • Texas Retina Associates

    COMPLETED

    Fort Worth, Texas, 76104, United States

  • The Cleveland Clinic Foundation

    COMPLETED

    Cleveland, Ohio, 44195, United States

  • The Retina Care Center

    COMPLETED

    Baltimore, Maryland, 21209, United States

  • The Retina Institute - Chesterfield

    COMPLETED

    St Louis, Missouri, 63128, United States

  • The Retina Partners

    ACTIVE_NOT_RECRUITING

    Encino, California, 91436, United States

  • UCSF

    COMPLETED

    San Francisco, California, 94158, United States

  • UZ Leuven Gasthuisberg

    COMPLETED

    Leuven, 3000, Belgium

  • Universidade Federal de Sao Paulo - UNIFESPX

    RECRUITING

    São Paulo, São Paulo, 04023-062, Brazil

  • Universitatsklinikum Bonn

    RECRUITING

    Bonn, 53127, Germany

  • Universitatsklinikum Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20246, Germany

  • Universitatsklinikum Koln

    RECRUITING

    Cologne, 50937, Germany

  • Universitatsklinikum Munster

    RECRUITING

    Münster, 48149, Germany

  • Universitatsklinikum Tubingen

    RECRUITING

    Tübingen, 72076, Germany

  • Universitatsklinikum Ulm, Augenklinik und Poliklinik

    RECRUITING

    Ulm, 89075, Germany

  • Universitatsspital Basel Augenklinik Klinik

    RECRUITING

    Basel, 4056, Switzerland

  • University Retina and Macula Associates, PC

    COMPLETED

    Oak Forest, Illinois, 60452, United States

  • University of New Mexico

    COMPLETED

    Albuquerque, New Mexico, 87131, United States

  • Universitätsklinikum Freiburg, Klinik für Augenheilkunde

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Vista Klinik Ophthalmologische Klinik

    ACTIVE_NOT_RECRUITING

    Binningen, 4102, Switzerland

  • VitreoRetinal Surgery, PLLC.

    COMPLETED

    Minneapolis, Minnesota, 55435, United States

  • Wagner Kapoor Institute

    COMPLETED

    Virginia Beach, Virginia, 23454, United States

  • West Coast Retina Medical Group

    COMPLETED

    San Francisco, California, 94109, United States

  • Wolfe Eye Clinic

    COMPLETED

    West Des Moines, Iowa, 50266, United States

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