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New eye drug aims to offer cheaper option for blinding disease

NCT ID NCT07614776

Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 14 times

Summary

This phase 3 trial tests whether a new drug called ABP 938 works as well as the approved treatment Eylea HD for wet age-related macular degeneration, a leading cause of vision loss. About 304 people aged 50 and older with untreated wet AMD will receive injections of either drug into the eye. The main goal is to see if vision improvement is similar between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ABP 938 (a biosimilar of aflibercept) and aflibercept (Eylea HD)
What this could lead to
If successful, this could provide a more affordable treatment option for wet age-related macular degeneration, helping preserve vision.
What could go wrong
This is a similarity study, not a new cure. Even if ABP 938 works as well as Eylea HD, it still requires regular eye injections and does not restore lost vision.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 304 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men or women ≥ 50 years old, capable of giving signed informed consent * Active, treatment-naïve subfoveal CNV lesions secondary to nAMD including juxtafoveal lesions that affect the fovea as confirmed by SD-OCT and FA in the study eye (SE) * Total area of CNV (including both classic and occult components) \> 50% of the total lesion area in the SE * The BCVA letter score ≥ 24 and ≤ 78 letters, in the SE * Presence of intra and/or subretinal fluid affecting the central subfield of the SE as identified by SD-OCT attributable to active CNV. The central subfield is defined as a circle with a diameter of 1 mm, centered on the fovea Exclusion Criteria: Participants are excluded from the study if any of the following criteria apply at either screening or baseline, unless otherwise indicated per protocol: * Total lesion size \> 12 disc areas (30.5 mm2) including blood, scars, and neovascularization, in the study eye * Scar, fibrosis, or atrophy involving the central subfield in the study eye * Scar or fibrosis involving \> 50% of the total lesion in the study eye * Presence of retinal pigment epithelium tears or rips involving the macula in the study eye * History of any vitreous hemorrhage ≤ 4 weeks (28 days) before randomization in the study * Presence of other causes of CNV, including pathologic myopia (spherical equivalent ≥ 8 diopters negative or axial length ≥ 25 mm), ocular histoplasmosis syndrome, angioid streaks, choroidal rupture, or multifocal choroiditis in the study * Uncontrolled glaucoma (defined as IOP \>25 mmHg despite treatment with anti-glaucoma medication) in the study eye * History or clinical evidence of DR, DME, idiopathic autoimmune uveitis, or any other vascular disease affecting the retina, other than nAMD in either eye * Evidence of active extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening or randomization * Uncontrolled blood pressure (defined as systolic \>160 mmHg or diastolic \>95 mmHg). Blood pressure needs to be stable for at least 12 weeks (84 days) prior to screening * Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti VEGF or anti-VEGF/anti-angiopoietin agent) in the SE, or surgery for nAMD in the SE, except dietary supplements or vitamins * History or evidence of any other clinically significant disorder, condition, disease or clinical laboratory abnormality that, in the opinion of the investigator or study medical monitor, if consulted, would pose a risk to participant safety or interfere with the study evaluation or results interpretation * Other protocol-specified exclusion criteria

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Conditions

The condition(s) this trial relates to.

nemaline myopathy wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAMD Neovascular age-related macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    64 sites in 6 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AXON clinical

    RECRUITING

    Prague, Prague, 150 00, Czechia

  • Advanced Research, LLC

    RECRUITING

    Pensacola, Florida, 32503, United States

  • Associated Vitreoretinal and Uveitis Consultants

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Austin Retina Associates

    RECRUITING

    Austin, Texas, 78705, United States

  • Austin Retina Associates - Ophthalmology/Retina

    RECRUITING

    Austin, Texas, 78705, United States

  • California Eye Specialists Medical Group, Inc

    RECRUITING

    Pasadena, California, 91107, United States

  • California Retina Consultants

    RECRUITING

    Santa Barbara, California, 93103, United States

  • Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o.

    RECRUITING

    Olsztyn, Warmian-Masurian Voivodeship, 10-424, Poland

  • Charleston Neuroscience Institute

    RECRUITING

    Charleston, South Carolina, 29414-5896, United States

  • Colorado Retina Associates (RCA)

    RECRUITING

    Lakewood, Colorado, 80228, United States

  • Emerson Clinical Research- Virginia Retina Specialists

    RECRUITING

    Falls Church, Virginia, 22042-2349, United States

  • Envision Ocular, LLC

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

  • Eye Care Specialists - Kingston

    RECRUITING

    Kingston, Pennsylvania, 18704-4801, United States

  • Fakultna nemocnica Trencin - Ocna klinika

    RECRUITING

    Trenčín, Trenčín Region, 911 71, Slovakia

  • Fakultna nemocnica s poliklinikou Zilina - Ocne oddelenie

    RECRUITING

    Žilina, Žilina Region, 012 07, Slovakia

  • Latvian American Eye Center

    RECRUITING

    Riga, Riga, LV-1009, Latvia

  • Medeye Associates - Research

    RECRUITING

    Miami, Florida, 33143, United States

  • Mid Atlantic Retina Specialists

    RECRUITING

    Hagerstown, Maryland, 21740-5846, United States

  • Midwest Retina - Main Office

    RECRUITING

    Dublin, Ohio, 43016, United States

  • Mississippi Retina Assoc

    RECRUITING

    Madison, Mississippi, 39110, United States

  • NC Retina Associates-RCA

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

  • North Carolina Retina Associates

    RECRUITING

    Raleigh, North Carolina, 27607-7514, United States

  • NsP Trebisov, a.s. - Ocne oddelenie

    RECRUITING

    Trebišov, Košice Region, 075 01, Slovakia

  • Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje - Klaudianova nemocnice

    RECRUITING

    Mladá Boleslav, Stredoceský Kraj, 293 01, Czechia

  • Ophthalmic Consultants of Boston

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Ophthalmic Consultants of Long Island - Research

    RECRUITING

    Oceanside, New York, 11572, United States

  • Palmetto Retina Center - Main (RCA)

    RECRUITING

    Columbia, South Carolina, 29169, United States

  • Palmetto Retina Center, Florence (RCA)

    RECRUITING

    West Columbia, South Carolina, 29169, United States

  • Retina Associates

    RECRUITING

    Elmhurst, Illinois, 60126, United States

  • Retina Associates of Utah - Retina Specialist

    RECRUITING

    Salt Lake City, Utah, 84107, United States

  • Retina Center NW PLLC

    RECRUITING

    Silverdale, Washington, 98383, United States

  • Retina Consultants of Minnesota

    RECRUITING

    Edina, Minnesota, 55435, United States

  • Retina Consultants of Orange County

    RECRUITING

    Fullerton, California, 92835-3432, United States

  • Retina Consultants of South Carolina, Charleston Neuroscience Institute- Ladson (RCA)

    RECRUITING

    Ladson, South Carolina, 29456, United States

  • Retina Consultants of South Carolina, Charleston Neuroscience Institute- Mount Pleasant (RCA)

    RECRUITING

    Mt. Pleasant, South Carolina, 29464, United States

  • Retina Consultants of South Carolina, Charleston Neuroscience institute - Blufffon (RCA)

    RECRUITING

    Beaufort, South Carolina, 29902, United States

  • Retina Consultants of Southern Colorado (Colorado Springs)- RCA

    RECRUITING

    Colorado Springs, Colorado, 80909-1183, United States

  • Retina Consultants of Southern Colorado (Pueblo)- RCA

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • Retina Consultants of Southwest Florida - Naples

    RECRUITING

    Naples, Florida, 34103-4457, United States

  • Retina Consultants of Texas - Bellaire

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Retina Consultants of Texas - Katy Retina Center

    RECRUITING

    Houston, Texas, 77401, United States

  • Retina Consultants of Texas - Schertz

    RECRUITING

    Schertz, Texas, 78154, United States

  • Retina Consultants of Texas - The Woodlands

    RECRUITING

    Katy, Texas, 77494, United States

  • Retina Group of New England

    RECRUITING

    Waterford, Connecticut, 06385, United States

  • Retina Specialists

    RECRUITING

    Towson, Maryland, 21204, United States

  • Retina Vitreous Surgeons of CNY, PC

    RECRUITING

    Liverpool, New York, 13088, United States

  • Retinal Consultants Medical Group, Inc - Sacramento - Parkcenter Drive (RCA)

    RECRUITING

    Sacramento, California, 95825, United States

  • Retinal Consultants Medical Group, Inc.-Sacramento, Greenback Lane, (RCA)

    RECRUITING

    Modesto, California, 95356, United States

  • Retinal Consultants of Texas- San Antonio

    RECRUITING

    San Antonio, Texas, 78240, United States

  • South Coast Retina Center - RCA

    RECRUITING

    Long Beach, California, 90607, United States

  • Spokane Eye Clinic (OCT and optical exam

    RECRUITING

    Spokane, Washington, 99204-2509, United States

  • Strategic Clinical Research Group, LLC

    RECRUITING

    Willow Park, Texas, 76087, United States

  • Szpital sw. Rozy Sp. z o.o.

    RECRUITING

    Kraków, Masovian Voivodeship, 30-363, Poland

  • Tennessee Retina PC

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Texas Retina Associates (TRA) - Arlington

    RECRUITING

    Arlington, Texas, 76012, United States

  • Texas Retina Associates (TRA) - Dallas Main

    RECRUITING

    Dallas, Texas, 75231, United States

  • Texas Retina Associates - Fort Worth

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • The Retina Care Center- Baltimore (PRISM Vision Group)

    RECRUITING

    Baltimore, Maryland, 21209, United States

  • The Retina Institute, Research Retina Institute (RCA)

    RECRUITING

    St Louis, Missouri, 63128, United States

  • Tokyo Medical Center - Ophthalmology

    RECRUITING

    Meguro-ku, Tokyo, 152-8902, Japan

  • University Retina - Bedford Park Location

    RECRUITING

    Oak Forest, Illinois, 60452, United States

  • Vision Research Center Eye Associates of New Mexico

    RECRUITING

    Albuquerque, New Mexico, 87109, United States

  • Visus, spol. s r.o. - Nachod

    RECRUITING

    Náchod, Hradec Králové Region, 547 01, Czechia

  • Vitreoretinal Associates of Washington

    RECRUITING

    Bellevue, Washington, 98004-3779, United States

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