Lazy eye breakthrough: glasses may restore vision in adults
NCT ID NCT05394987
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether wearing the right glasses can improve vision in adults with amblyopia (lazy eye). Researchers will measure how well participants see before, during, and after wearing custom spectacles. The goal is to see if the adult brain can still learn to see better with just optical correction. 36 adults aged 18-39 with lazy eye will take part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2022
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 39 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-39 (inclusive) years of age * Anisometropic amblyopia (difference of ≥0.50D spherical equivalent or ≥1.50D astigmatism between eyes) or mixed mechanism amblyopia (strabismus and anisometropia) * Best corrected visual acuity (BCVA) in the amblyopic eye of 0.3 logMAR to 1.0 logMAR (inclusive) * BCVA in the non-amblyopic eye of 0.1 logMAR or better, and an interocular VA difference of 2 logMAR lines or more * Difference of 1.00D or more between current refractive correction and study prescription * Good general health Exclusion Criteria: * Other pathological ocular anomalies known to cause reduced visual acuity * Presbyopia (based on amplitude of accommodation) * Inability to tolerate prescribed refractive correction in spectacles (e.g., due to aniseikonia) * Contraindication to cycloplegic eye drops * Currently under amblyopia treatment/therapy * Inability to comprehend test instructions and/or provide consent * Eccentric fixation * \>-6.00DS of myopia in either eye with spectacles * Bilateral amblyopia * Presence of amblyopia that is not due to strabismus and/or anisometropia * Presence of (current or previous) psychiatric, visual, or neurological disorders
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre for Eye and Vision Research Limited
RECRUITINGHong Kong, Guangdong, 00000, Hong Kong
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University of Waterloo
RECRUITINGWaterloo, Ontario, N2L 3G1, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mixed-Reality headset trains eyes to work together in adults with lazy eye
- A new exercise for the eyes: could it restore 3D vision?
- Video games vs eye patches: a new hope for lazy eye?
- Adult lazy eye may be trainable: brain plasticity under the microscope
- Can a gentle brain zap help adults with lazy eye see better?
- Magnetic pulses to the brain may restore vision in adult lazy eye