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Virtual reality could spot eye nerve damage earlier than flashlight test

NCT ID NCT05799066

Diagnosis Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a virtual reality headset combined with machine learning can measure pupil reactions more reliably than the standard flashlight test for Relative Afferent Pupillary Defect (RAPD). About 71 adults with and without known RAPD took part. Researchers compared manual measurements with those from the VR system to see if the new method could detect RAPD earlier or more objectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

71 people

The number who actually took part.

Started

May 2023

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 - 85 * 60 patients with known RAPD. * 60 patients with no known RAPD * May be diagnosed with a vision disorder such as glaucoma, diabetic retinopathy, unilateral or asymmetrical disease of the retina or other degenerative ocular diseases * Referred to study by treating eye doctor * Volunteered to participate in study * UTMB clinic patients * Not belonging to an identified vulnerable population Exclusion Criteria: * Younger than 18; older than 85 years of age * Not a UTMB clinic patient * Belonging to an identified vulnerable population * Participants with discomfort using glasses * Experience discomfort using VR HMD device * Participants with history of congenital pupil defects, traumatic pupils * Those whose pupils were dilated during the standard of care examination deemed by treating eye doctor not to be eligible to participate in study * Participants who do not follow study directions and/or safety procedures given by investigators or lab assistants * Participants who do not speak English to prevent a communication error during the informed consent process

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Conditions

The condition(s) this trial relates to.

Pupil Disorders vision disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Relative afferent pupil defect (RAPD)

Contacts and locations

Locations

  • University of Texas Medical Branch

    Galveston, Texas, 77555, United States