Nasal spray could replace needles for sickle cell pain emergencies
NCT ID NCT04076748
First seen Jun 12, 2026 · Last updated Jun 23, 2026 · Updated 3 times
Summary
This study tested a nasal spray containing a strong painkiller (sufentanil) for adults with sickle cell disease experiencing a painful crisis. The goal was to see if it could provide faster relief than the standard gas mixture (EMONO) before giving morphine through an IV. The trial was stopped early, so the full results are not available.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CH de Cayenne
Cayenne, 97306, French Guiana
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CHU Pointe à Pitre
Les Abymes, 97159, Guadeloupe
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Gonesse Hospital
Gonesse, 95500, France
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Hopital Pellegrin
Bordeaux, 33000, France
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Hôpital Charles Nicolle
Rouen, 76031, France
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Hôpital Edouard Herriot
Lyon, 69003, France
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Hôpital Louis Mourier
Colombes, 92700, France
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Hôpital Rangueil
Toulouse, 31059, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sufentanil (a strong painkiller given as a nasal spray)
What this could lead to
If it worked, this could offer a faster, needle-free way to ease severe sickle cell pain in the emergency room.
What could go wrong
The trial was terminated early, so results are limited. It is unclear if the nasal spray works better than the standard gas treatment, and strong painkillers carry risks like drowsiness or breathing problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.