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Can a Nerve-Blocking procedure outperform painkillers for cancer pain?

NCT ID NCT07761650

Symptom relief Sponsor: Mayo Hospital Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study tests whether a CT-guided nerve block called celiac plexus neurolysis can relieve severe abdominal pain in people with upper gastrointestinal cancer better than standard pain medication. About 110 adults with biopsy-proven upper GI cancer and severe pain will be randomly assigned to receive either the nerve block or usual pharmacotherapy. Pain levels are measured at the start and after four weeks to see which approach offers greater relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CT-guided celiac plexus neurolysis (a procedure that uses alcohol to block pain nerves in the abdomen)
What this could lead to
If effective, this procedure could offer a more powerful and longer-lasting option for managing severe cancer-related abdominal pain, potentially reducing reliance on painkillers.
What could go wrong
The trial is relatively small and early-stage, and the procedure carries risks such as bleeding, infection, or nerve damage. Pain relief may not be better than standard medication for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

May 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Biopsy proven upper GI malignancy with severe abdominal pain * Patients aged 18 to 65 years of either gender Exclusion Criteria: * Pregnant and lactating females * Anemia (hemoglobin \<10 g/dL) * Massive ascites * Chronic renal failure * Patients with known allergy or intolerance to drugs used during celiac plexus neurolysis (CT guided technique).

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Conditions

The condition(s) this trial relates to.

agnosia digestive system neoplasm gastroesophageal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Upper abdominal malignancies Upper gastrointestinal cancer

Contacts and locations

Locations

  • Mayo Hospital

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.