Refillable eye implant could replace monthly shots for diabetic eye disease
NCT ID NCT04503551
First seen Jan 03, 2026 · Last updated Jun 23, 2026 · Updated 27 times
Summary
This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center of the retina. The main goal was to see if the implant could improve the severity of retinopathy by at least two steps on a standard scale after one year, compared to standard monthly eye injections.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asheville Eye Associates Western Carolina Retinal Associates;Clinical Research
Asheville, North Carolina, 28803, United States
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Associated Retina Consultants
Phoenix, Arizona, 85020, United States
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Associated Retinal Consultants - Royal Oak
Royal Oak, Michigan, 48073, United States
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Austin Retina Associates;Opthalmology
Austin, Texas, 78705, United States
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Barnet Dulaney Perkins Eye Center
Mesa, Arizona, 85206, United States
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California Eye Specialists Medical Group
Pasadena, California, 91107, United States
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California Retina Consultants
Bakersfield, California, 93309, United States
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Cape Fear Retinal Associates
Wilmington, North Carolina, 28401, United States
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Charles Retina Institution;Retina surgery
Germantown, Tennessee, 38138, United States
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Charleston Neuroscience
Ladson, South Carolina, 29456, United States
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Charlotte Eye Ear Nose and Throat Associates- SouthPark;Retina
Charlotte, North Carolina, 28210, United States
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Colorado Clinical Research
Lakewood, Colorado, 80228, United States
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Cumberland Valley Retina Consultants;Clinical Research
Hagerstown, Maryland, 21740, United States
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Duke Eye Center
Durham, North Carolina, 27705, United States
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Emanuelli Research & Development Center
Arecibo, 612, Puerto Rico
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Envision Ocular, LLC
Bloomfield, New Jersey, 07003, United States
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Fort Lauderdale Eye Institute
Plantation, Florida, 33324, United States
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Georgia Retina
Marietta, Georgia, 30060, United States
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Illinois Retina Associates
Joliet, Illinois, 60435, United States
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Johns Hopkins Hospital;Johns Hopkins Med;Wilmer Eye Inst
Baltimore, Maryland, 21287, United States
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Jules Stein Eye Institute/ UCLA
Los Angeles, California, 90095, United States
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Kaiser Permanente;RESEARCH AND EVALUATION
Riverside, California, 92505, United States
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Maine Eye Center
Portland, Maine, 04605, United States
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Medical Center Ophthalmology Associates
San Antonio, Texas, 78240, United States
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Mid Atlantic Retina;Retina Research
Philadelphia, Pennsylvania, 19107, United States
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New York University (NYU)
New York, New York, 10012, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Ohio State Havener Eye Institute;Ophthalmology Research
Columbus, Ohio, 43212, United States
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Orange County Retina Medical Group
Santa Ana, California, 92705, United States
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Pacific Northwest Retina
Silverdale, Washington, 98383, United States
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Palmetto Retina Center
West Columbia, South Carolina, 29169, United States
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Pepose Vision Institute
Chesterfield, Missouri, 63017, United States
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Piedmont Eye Center
Lynchburg, Virginia, 24502, United States
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Retina & Vitreous of Texas
Bellaire, Texas, 77401, United States
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Retina Associates
Lenexa, Kansas, 66215, United States
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Retina Associates of Florida;Retina Associates of Florida
Tampa, Florida, 33609, United States
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Retina Associates of New Jersey
Teaneck, New Jersey, 07666, United States
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Retina Associates of Utah, PLLC;Clinical Research
Salt Lake City, Utah, 84107, United States
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Retina Center of Texas
Grapevine, Texas, 76051, United States
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Retina Consultants Medical Group
Sacramento, California, 95841, United States
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Retina Consultants of Hawaii at Pali Momi Medical Center
‘Aiea, Hawaii, 96701, United States
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Retina Consultants of Orange County;Clinical Research
Fullerton, California, 92835, United States
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Retina Consultants of Texas
Houston, Texas, 77401, United States
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Retina Consultants of Texas
The Woodlands, Texas, 77384, United States
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Retina Group of New England
Waterford, Connecticut, 06385, United States
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Retina Institute of Virginia
Richmond, Virginia, 23235, United States
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Retina Northwest;Research Department
Portland, Oregon, 97221, United States
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Retina Research Institute of Texas
Abilene, Texas, 79606, United States
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Retina Specialty Institute
Pensacola, Florida, 32503, United States
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Retina Vitreous Center - Glen Eagles
Edmond, Oklahoma, 73013, United States
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Retina Vitreous Surgeons of Central New York
Liverpool, New York, 13088, United States
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Retinal Consultants of Arizona;Opthalmology
Phoenix, Arizona, 85014, United States
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Rocky Mountain Retina Consultants
Murray, Utah, 84107, United States
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Sierra Eye Associates
Reno, Nevada, 89502, United States
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Southeast Retina Center
Augusta, Georgia, 30909, United States
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Southeastern Retina Associates
Knoxville, Tennessee, 37922, United States
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Southwest Retina Research Center
Durango, Colorado, 81303, United States
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Spokane Eye Clinical Research;Spokane Eye Surgery Center
Spokane, Washington, 99204, United States
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Tennessee Retina
Nashville, Tennessee, 37203, United States
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Texas Retina Associates;Research
Dallas, Texas, 75231, United States
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The Retina Care Center
Baltimore, Maryland, 21209, United States
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The Retina Partners
Encino, California, 91436, United States
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University Retina
Lemont, Illinois, 60439, United States
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VitreoRetinal Surgery PLLC;DBA Retina Consultants of Minnesota
Minneapolis, Minnesota, 55435, United States
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Wagner Kapoor Institute;Opthalmology
Norfolk, Virginia, 23502, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ranibizumab
What this could lead to
If successful, this implant could offer a long-lasting way to control diabetic retinopathy, reducing the need for monthly eye injections.
What could go wrong
This is a completed phase 3 trial, but results may not apply to all patients. The implant requires a surgical procedure and carries risks like infection or implant issues.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.