DIABETIC RETINOPATHY

This study compares two ways of using laser treatment for proliferative diabetic retinopathy, a leading cause of blindness in working-age adults. Researchers will give 40 participants either a single laser session or multiple sessions to see which is safer and works better. The g…

This early-stage trial tests an oral drug called MS-553 in 45 people with diabetic macular edema, a condition where diabetes causes fluid buildup in the eye's center, blurring vision. Participants take the drug daily for 8 weeks to check its safety and whether it reduces swelling…

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests whether levosulpiride, a drug already used for other conditions, can safely improve vision and reduce retinal swelling in people with diabetic retinopathy and diabetic macular edema. About 120 adults aged 40-69 with mild to moderate eye damage will receive either…

This early study tests a new dye called MB-102 for eye imaging (angiography) in 10 people with or without retinal diseases like diabetic retinopathy or macular degeneration. The goal is to see if MB-102 is safe and produces clear images compared to the standard dye, fluorescein s…

This study tests an AI software called iPredict-DR that looks at photos of the retina to find early signs of diabetic retinopathy, a leading cause of blindness. The goal is to see if the AI can detect the disease as accurately as eye doctors, so that screening can happen in regul…

This study compares two ways of screening for diabetic retinopathy, a leading cause of blindness. In one group, a portable camera takes pictures of the eye and artificial intelligence (AI) analyzes them. In the other group, the same camera is used but an eye doctor reads the imag…

This study is testing whether a simple vision screening done in a regular doctor's office can help find vision problems early in people over 70 who have at least one chronic condition like diabetes or high blood pressure. About 460 participants will be invited to take vision test…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It takes pictures of the back of the eye using many different colors of light to find details that standard cameras miss. Researchers will compare this new method with current imaging in 1000…

This study tests whether fenofibrate, a drug typically used for cholesterol, can stop diabetic retinopathy from worsening in people with mild to moderate disease. About 560 adults with diabetes will take either fenofibrate or a placebo for up to 6 years. The goal is to see if the…

This study looks at whether taking melatonin can improve sleep and daily body rhythms in people with diabetic retinopathy, an eye problem caused by diabetes. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65. The goal is to see if a simple supplemen…

This study uses a special eye scan (OCT angiography) to track changes in retinal blood vessel diseases like diabetic retinopathy and vein occlusion. Researchers will follow over 1,000 participants, including healthy volunteers, to see how imaging patterns relate to disease stage.…

This study looks at whether activating a protein called LXR can help prevent diabetic retinopathy, a common eye problem in people with diabetes. Researchers will test blood cells from 104 adults with and without diabetes to see how LXR affects cell repair and inflammation. The go…

This study follows 100 adults with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Over two years, researchers will use advanced eye scans to track tiny changes in blood vessels and retinal layers. The goal is to find earl…

This study looks at a protein called sCD160 in the eye fluids and blood of people with diabetic retinopathy or retinal vein occlusion. Researchers want to see if higher levels of this protein are linked to more severe eye damage. The goal is to better understand these vision-thre…

This study tests a new imaging tool that gives surgeons a live, 3D view inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or diabetic retinopathy, as well as healthy volunteers. The goal is to see if this t…

This study is testing whether short videos featuring Latino patients and doctors can encourage more Latinx adults with diabetes to get annual eye exams. Researchers will survey about 1,500 people and hold small group discussions to see if the videos improve eye health knowledge a…

This study looks at how to better detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. Researchers will use eye images, clinical data, and blood tests to create an early warning system and tailor treatment based on when diabetes started and other heal…

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to create a research database to help scientists understand why some people get eye diseases and oth…

This study explores whether special stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will take blood from 20 people with diabetes and healthy volunteers to create these stem cells in a lab. The …

This observational study will follow about 1,000 people with type 2 diabetes, aged 35 to 90, for one year. Researchers want to see if changes in the eye's blood vessels and tissues can predict which patients will develop more severe diabetic retinopathy or have heart problems lik…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…