DIABETIC RETINOPATHY

This study tests a gene therapy called 4D-150 for people with diabetic macular edema, a condition that causes vision loss due to diabetes. The goal is to see if a single injection of the gene therapy can reduce the need for frequent eye injections over two years. About 72 adults …

This early-stage study tests whether it is safe to inject a person's own bone marrow stem cells into their eye to treat blindness caused by retinal diseases like macular degeneration and diabetic retinopathy. Fifteen adults with severe vision loss will receive one injection and b…

This study tests a new medicine called BI 764524 for people with moderate to severe diabetic retinopathy, a diabetes-related eye disease. About 188 adults will receive different numbers of eye injections over a year, and doctors will compare their eye health to those getting a sh…

This study tests whether levodopa, a drug used for Parkinson's, can slow the development of diabetic retinopathy—a common eye problem in people with diabetes. Researchers will give the drug to 244 adults with early signs of retinal changes and measure eye health using non-invasiv…

This study tests whether a daily pill called fenofibrate can slow or prevent worsening of diabetic eye disease (retinopathy) in adults with type 1 diabetes. About 412 participants with early eye changes are taking either the drug or a placebo for several years. The goal is to see…

This study looks at whether a special type of eye scan (functional OCT) can detect early signs of diabetic retinopathy, a leading cause of blindness. Currently, doctors use a dye injection to see blood vessel damage, but this dye can cause side effects. The study involves 165 peo…

This study tests a new type of eye scan called OCT angiography (OCTA) that doesn't require dye injections to see blood vessels in the eye. Researchers want to see if it can measure damage from diabetic retinopathy as well as or better than current methods. About 290 people with d…

This study looks at how inflammation affects diabetic retinopathy, an eye disease that can lead to vision loss in people with diabetes. Researchers are measuring inflammatory markers in eye fluid and testing whether ketorolac eye drops can reduce these markers and slow disease pr…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study looks at whether a program called I-SITE can help more people with diabetes get their eyes checked using telemedicine (remote eye photos). Over 12,000 patients from urban health systems are included. The goal is to see if this approach increases screening rates and hel…

This study tests a program called I-SITE that helps rural health systems use telemedicine to screen for diabetic eye disease. Up to 10 rural health systems and about 10,000 patients with diabetes will take part. The goal is to see if the program increases the number of patients w…

This study looks at blood stem cells (called EPCs) in people with diabetes and healthy volunteers to see if these cells work differently in diabetes. Researchers want to know if the function of these cells can predict diabetic retinopathy, an eye disease that can cause blurred vi…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…

This study is gathering information on the blood vessels in the eyes of healthy children aged 6 to 15. Researchers will compare this data with that of children who have type 1 diabetes. The goal is to better understand early changes that could lead to diabetic retinopathy, a seri…

This study tests whether AI software can help eye doctors diagnose four common eye diseases—diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma—more accurately and quickly. Ten doctors will review eye images with and without AI assistance.…