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Sound waves in the ear: a new hope for tinnitus?

NCT ID NCT07291648

Symptom relief Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether people with tinnitus can tell if they are receiving real or fake ultrasound stimulation of the vagus nerve in the ear. Twenty adults with constant tinnitus for at least six months took part. The goal was to see how well the blinding worked and what side effects occurred, not to measure tinnitus relief. The device, called ZenBud, uses focused ultrasound to stimulate the nerve, which may help normalize brain activity linked to tinnitus.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasound Vagus Nerve Stimulation (U-VNS) using the ZenBud device
What this could lead to
If this approach works, it could point toward a non-invasive, targeted treatment for tinnitus that avoids the side effects of electrical stimulation.
What could go wrong
This is a very small, early-stage study (20 people) focused on blinding and side effects, not on whether the treatment actually reduces tinnitus. The device may not prove effective in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or over * Has experienced constant idiopathic tinnitus for at least 6 months * Participant is willing and able to give informed consent for participation in the study * Not currently taking any medication (except the contraceptive pill) * Able and willing to remove any piercings in the left ear Exclusion Criteria: * Current or past diagnosis of a neurological or psychiatric condition * Current or past diagnosis of cardiac arrhythmia * No tinnitus * Has tinnitus, but it is objective, intermittent or onset is less than 6 months ago * Use of medication or recreational drugs that affect the nervous system in the past 3 months * Currently pregnant * Allergy to aquasonic gel or any of its components (propylene glycol, glycerin, isothiazolinones) * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)

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Conditions

The condition(s) this trial relates to.

tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tinnitus

Contacts and locations

Locations

  • University of Nottingham

    Nottingham, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.