New speech therapy shows promise for kids with apraxia
NCT ID NCT03903120
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a speech therapy called ASSIST for children aged 4 to 9 with childhood apraxia of speech, a disorder that makes it hard to plan speech movements. Fifty-one children received 16 hours of individual therapy using repetition and cues. The goal was to see if the therapy improves speech accuracy and everyday communication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ASSIST (a behavioral speech therapy using repetition and cues)
- What this could lead to
- If successful, this could point toward a more effective therapy for children with apraxia of speech, improving their ability to speak clearly.
- What could go wrong
- This is an early Phase 1 study with only 51 children, so results may not apply to all. The therapy is intensive and may not work for every child.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
51 people
The number who actually took part.
- Started
-
Apr 2019
- Finished
-
Nov 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
4 to 9 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age between 4;0 and 9;11 (years;months) at enrollment, based on parent report. 2. From homes where the primary language spoken is English, based on parent report. 3. Verbal output (50+ words) and communicative intent, as determined by the clinician and parent report. 4. Speech sound disorder, as determined by a score \<16th percentile on the Diagnostic Evaluation of Articulation and Phonology (DEAP) Articulation Assessment (Dodd et al., 2006) and/or the Goldman-Fristoe Test of Articulation (Goldman \& Fristoe, 2015). 5. CAS as a primary speech diagnosis, based on the following criteria: 1. An average rating \> 1 across three expert speech-language pathologists (SLPs), who will independently rate presence of CAS in children live or from video recordings of the assessment using a 3-point scale (0 = no CAS, 1 = possible CAS, 2 = CAS). These judgments will be based on perceptual speech features of CAS (inconsistent vowel and consonant errors, difficulties achieving and transitioning into articulatory configurations, abnormal prosody). 2. An Apraxia Score of 1 or 2 on a Maximum Performance protocol in which they sustain vowels and fricatives as long as possible and repeat syllables as fast as possible (Rvachew et al., 2005; Thoonen et al., 1999). 6. Normal hearing based on parent report or passing a standard pure-tone audiometry hearing screening at 500, 1000, 2000, and 4000 Hz (ASHA, 1997). 7. Typical nonverbal cognition as determined by a T-score within 1.5 standard deviation (SD) of the mean on nonverbal subtests of the Reynolds Intellectual Assessment Scales (Reynolds \& Kamphaus, 2003). Exclusion Criteria: 1. Diagnosis of disorder that significantly affects communication and/or social interactions (e.g., autism), as per referral diagnosis. 2. Uncorrected vision impairments that may interfere with ability to process visual cues used in treatment, as per parent report. 3. Significant impairments of oral structure (e.g., cleft palate) as judged by the SLP based on an oral mechanism exam (Robbins \& Klee, 1987). 4. A primary diagnosis of dysarthria, as judged by the SLP. 5. Unrelated health concerns that prevent children from participating, per parent report. 6. Inability to meet toileting needs independently or separate from parent for a full day (as needed for camp), based on parent report.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Childhood apraxia of speech are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Temple University
Philadelphia, Pennsylvania, 19122, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can intensive speech therapy rewire speech in children with rare genetic conditions?
- New speech therapy approach tested for kids with apraxia
- New therapy aims to help kids with speech disorder speak in phrases
- Parent training boosts speech therapy for kids with apraxia
- New speech therapy shows promise for kids with apraxia
- Could a fish oil supplement help kids with speech apraxia?