Could a simple injection cut post-hysterectomy pain?
NCT ID NCT07426666
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether injecting the numbing drug bupivacaine into the vaginal cuff during vaginal hysterectomy reduces pain after surgery. Forty-eight women were randomly assigned to receive either the injection or standard care. Pain levels were measured over 24 hours using a standard pain scale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- bupivacaine
- What this could lead to
- If it works, this could offer a simple way to reduce pain after vaginal hysterectomy, potentially improving recovery and patient comfort.
- What could go wrong
- This is a small, completed study with only 48 participants. Results may not apply to all patients, and the effect may be modest or not clinically significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
48 people
The number who actually took part.
- Started
-
Aug 2025
- Finished
-
Oct 2025
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 75 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women aged 35 to 75 years Scheduled for elective vaginal hysterectomy for benign gynecologic indications (e.g., uterine fibroids, adenomyosis, abnormal uterine bleeding, pelvic organ prolapse) Able to provide written informed consent Exclusion Criteria: Known or suspected gynecologic malignancy (endometrial, cervical, or uterine) Allergy or hypersensitivity to local anesthetics, especially bupivacaine Prior pelvic radiotherapy or major pelvic surgery resulting in altered anatomy Conditions preventing vaginal cuff injection (e.g., extensive scarring, active infection) Inability to reliably assess pain (e.g., impaired consciousness, dementia, severe psychiatric disorder) Refusal to sign informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
SBÜ Gaziosmanpaşa Training and Research Hospital
Istanbul, Outside of the US, 33400, Turkey (Türkiye)
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