Could zapping a different brain region tame epilepsy?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: between 18 and 60 years old * Focal or multifocal drug-resistant epilepsy not operable or failure of epilepsy surgery * Vagal nerve stimulation failure (after at least 1 year of treatment or stopped early for worsening seizures) * Either patients with epilepsy whose characteristics suggest that it may respond better to stimulation of the pulvinar than the anterior thalamic nucleus stimulation (i.e. posterior quadrant epilepsy, motor/premotor epilepsy, operculo-insular epilepsy, temporal plus epilepsy, lateral temporal epilepsy) or/and patients with previous anterior thalamic nucleus stimulation failure (after 2 years of treatment or stopped early for worsening seizures) * Number of seizures \> 4 / month during the baseline (3 months) and before the V0 for at least 3 months * Total IQ \> 55 * Give written consent to the study after receiving clear information * Be a beneficiary or affiliated to a health insurance plan * For women of childbearing potential, a pregnancy test must be negative before inclusion. Exclusion Criteria: * Difficulty to read or understand the French language, or inability to understand the information regarding the study. * Generalized epilepsy * Presenting contraindication to MRI, a serious intercurrent pathology, a progressive brain tumor. * Pregnancy or breastfeeding * Present a history of attempted suicide in the 6 months prior to inclusion or a score ≥ 2 in item 10 of the Montgomery and Asberg Depression Scale (MADRS). * Present a surgical or anaesthetic contraindication. * Require long-term anticoagulant or platelet aggregation therapy. * Hereditary bleeding disorders of coagulation * Non obliterated AVM * History of Herpes virus brain infection * Total IQ below 55. * Patients with less than 4 seizures a month * To be hospitalized under duress (HO / HDT) * Major under guardianship or curatorship * Person deprived of liberty by judicial decision * Patient currently participating in another clinical trial or having participated in a clinical trial in the month prior to inclusion