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Freezing nerves may shorten hospital stay after chest surgery

NCT ID NCT05731973

Symptom relief Sponsor: Zuyderland Medisch Centrum Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested if freezing the nerves between the ribs (cryoablation) could reduce hospital stay compared to standard epidural pain medicine in 50 young people aged 12-24 having Nuss surgery for pectus excavatum (sunken chest). The goal was to see which method controls pain better and gets patients home sooner. Results will help doctors choose the best pain management approach for this procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Dec 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 24 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing the minimal invasive Nuss procedure for surgical repair of pectus excavatum. * Young patients (12-24 years of age) according to the definition used by the World Health Organization. This cut-off point is chosen to create a more homogenous patient sample, as the thoracic cage is fully matured by the age of 24, in size and density, which will have an effect on postoperative pain. Exclusion Criteria: * A chest wall deformity other than pectus excavatum; * Opioid use in the 3 months prior to surgery; * Pain syndrome (e.g., fibromyalgia) or neuropathic pain prior to surgical repair of pectus excavatum; * Connective tissue disease (e.g., Marfan syndrome, Ehlers-Danlos syndrome); * Previous thoracic surgery or pectus excavatum repair; * Contraindication for intercostal nerve cryoablation or thoracic epidural analgesia (e.g., patient refusal, infection at the site of cannulation, uncontrolled systemic infection, bleeding diathesis, increased intracranial pressure, mechanical spine obstruction); * Psychiatric disease currently receiving treatment; * Not mastering the Dutch language; * Participation in another clinical trial that may interfere with the current trial.

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Conditions

The condition(s) this trial relates to.

agnosia pectus excavatum

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Funnel chest Pectus excavatum

Contacts and locations

Locations

  • Zuyderland Medical Center

    Heerlen, Limburg, 6419 PC, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.