New hope for vision loss: Long-Term study of pegcetacoplan for dry AMD

NCT ID NCT04770545

Disease control Sponsor: Apellis Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested the long-term safety and effectiveness of pegcetacoplan in 792 people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes vision loss. Participants had previously been in earlier pegcetacoplan trials. The goal was to see if the drug remains safe and helps slow the growth of retinal damage over up to three years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: pegcetacoplan
What this could lead to: If successful, this could confirm pegcetacoplan as a long-term treatment option to slow the progression of geographic atrophy, preserving vision in patients with age-related macular degeneration.
What could go wrong: This is an extension study, so it builds on earlier trials; however, long-term safety and effectiveness are still being evaluated, and not all patients may benefit equally. Side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

792 people

The number who actually took part.

Started

Mar 2021

Finished

Sep 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants are eligible to be included in the study only if all of the following criteria apply: Ocular-specific inclusion criteria apply to the study eye only. * Subjects must have participated in APL2-103 (NCT03777332) or completed the treatment at Month 24 of either APL2-303 (Derby, NCT03525613) or APL2-304 (Oaks, NCT03525600). * For subjects who participated in either the 303 or 304 studies, the condition listed below must also be met for participating in this study. * Subjects who did not fully stop study drug treatment, but missed the visit at Month 24, can also participate in the study. However, to participate, subjects must be seen within 60 days from the last day of the period allowed for the 24 months visit in the previous study. * The eyes of subjects must have transparency to permit visualization of parts inside the eye such as the retina and subjects must be able to look steadily at a provided target allowing the doctor to get good quality pictures from the eye. * Female subjects must be: * Women that cannot have children, or * Women who can have children must have a negative result of a blood pregnancy test on the first day of the study visit and agree to use ways to avoid pregnancy during the study and 90 days after the last dose of the study medication. * Males with female partners who can get pregnant must also agree to use ways to avoid pregnancy and agree not to donate sperm while in the study or until 90 days after administering the last dose of the study medication. * Agree to participate in the study by signing the consent document providing information about the study; and take part in all tests and assessments as required. Exclusion Criteria: Subjects cannot take part in the study if the eye that will be treated during the study currently meets any of the following conditions: * Participants in APL2 303/304 studies who fully stopped study drug treatment before the visit in month 24 but remain in the study to observe the study medication's safety. Those subjects who temporarily paused study drug treatment are still eligible to participate. * If, according to your doctor you currently have any disease affecting your eyes that could interfere with your vision, including diseases that affect your retina or macula (the center of the back of your eyes). And, if according to your doctor, the disease in your eyes is benign and does not interfere with the study (e.g. diseases that affects the periphery of the retina), you are also eligible to take part in the study. * If, according to your doctor you currently have any inflammation/infection in or around your eyes that could prohibit you from receiving an injection inside your eyes. * If, according to your doctor, any current disease that could directly interfere in your participation in the study or that could make it difficult for you to come to the scheduled visits during the next three yearsover the next 36 months. * If you have known allergies to fluorescein sodium, a solution that is injected into your body for eye testing; or to pegcetacoplan (the study drug) or any inactive substances in pegcetacoplan solution. * If you currently are pregnant, breastfeed or have a positive pregnancy test.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Geographic atrophy secondary to age-related macular degeneration

Contacts and locations

Locations

AIO Visionary Eye Care

West Mifflin, Pennsylvania, 15122, United States
ASST Fatebenefratelli-Sacco Ospedale Luigi Sacco

Milan, 20157, Italy
AXON Clinical, s.r.o.

Prague, 150 00, Czechia
Academisch Medisch Centrum

Amsterdam, 1105 AZ, Netherlands
Assaf ha Rofeh MC

Be’er Ya‘aqov, 7030000, Israel
Associated Retina Consultants, Ltd.

Phoenix, Arizona, 85020, United States
Associated Retinal Consultants, PC

Grand Rapids, Michigan, 49546, United States
Associated Retinal Consultants, PC

Traverse City, Michigan, 49686, United States
Atlantis Eyecare

Huntington Beach, California, 92647, United States
Augenklinik der LMU Munchen

München, 80336, Germany
Augenzentrum am St. Franziskus-Hospital

Münster, 48145, Germany
Bascom Palmer Eye Institute

Miami, Florida, 33136, United States
Bascom Palmer Eye Institute at Naples

Naples, Florida, 34103, United States
Bay Area Retina Associates

Walnut Creek, California, 94598, United States
Black Hills Regional Eye Institute

Rapid City, South Dakota, 57701, United States
Blue Ocean Clinical Research

Clearwater, Florida, 33761, United States
Bristol Eye Hospital

Bristol, BS1 2LX, United Kingdom
Brown Retina Institute

Bellaire, Texas, 77401, United States
Byers Eye Institute, Stanford University

Palo Alto, California, 94303, United States
CHNO des Quinze-Vingts

Paris, 75012, France
CHU Dijon

Dijon, 21 079, France
CHU de Bordeaux

Bordeaux, 33076, France
CHU de Nantes - Hotel Dieu

Nantes, 44093, France
CHU de Strasbourg Hopital Civil

Strasbourg, 67091, France
California Retina Consultants

Bakersfield, California, 93309, United States
California Retina Consultants

Santa Barbara, California, 93103, United States
Center for Retina and Macular Disease

Winter Haven, Florida, 33880, United States
Centre Hospitalier Intercommunal de Creteil

Créteil, 94010, France
Centre Ophtalmo. Image/Laser

Paris, 75015, France
Centre Ophtalmol de l Odeon

Paris, 75006, France
Centre for Eye Research Australia

East Melbourne, Victoria, 3002, Australia
Centre monticelli Paradis

Marseille, 13008, France
Centre ophtalmologique Saint-Exupery

Saint-Cyr-sur-Loire, Lyon, 37540, France
Centro Oftalmologico Dr. Charles S.A.

Buenos Aires, C1116ABA, Argentina
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Charlotte Eye Ear Nose and Throat Associates, PS

Charlotte, North Carolina, 28210, United States
Cleveland Clinic Cole Eye Institute

Cleveland, Ohio, 44195, United States
Clinique du Val d'Ouest

Écully, 69130, France
Cumberland Valley Retina Center

Hagerstown, Maryland, 21740, United States
Danbury Eye Physicians & Surgeons, PC

Danbury, Connecticut, 06810, United States
Diagnostico Ocular

Buenos Aires, 1425, Argentina
Doheny Eye Center UCLA

Los Angeles, California, 90033, United States
Duke University, Duke Eye Center

Durham, North Carolina, 27710, United States
East Florida Eye Institute

Stuart, Florida, 34994, United States
Elman Retina Group

Baltimore, Maryland, 21236, United States
Emerson Clinical Research Institute

Falls Church, Virginia, 22046, United States
Eye Associates of Pinellas

Pinellas Park, Florida, 33782, United States
Eye Health Northwest

Portland, Oregon, 97225, United States
Eye Surgery Center Professor Zagorski

Bydgoszcz, 85-316, Poland
Fakultni Nemocnice Ostrava

Ostrava-Poruba, 708 52, Czechia
Florida Eye Microsurgical Institute, Inc.

Boynton Beach, Florida, 33426, United States
Fundacion Zambrano

Buenos Aires, C1023 AAQ, Argentina
Gailey Eye Clinic Retina Center

Bloomington, Illinois, 61704, United States
Gemini Eye Clinic

Zlín, 760 01, Czechia
Georgia Retina, PC

Marietta, Georgia, 30060, United States
Graystone Eye

Hickory, North Carolina, 28602, United States
Grupo Laser Vision

Rzeszów, 35-017, Poland
Hadassah Medical Center

Jerusalem, 91120, Israel
Hamilton Eye Clinic

Hamilton, 3204, New Zealand
Hopital Lariboisiere

Paris, 75010, France
Hopital de la Croix-Rousse

Lyon, 69004, France
Hospital Universitario Puerta de Hierro

Madrid, 28222, Spain
Houston Eye Associates

Houston, Texas, 77025, United States
Huddersfield Royal Infirmary

Huddersfield, West Yorkshire, HD3 3EA, United Kingdom
IPEPO Instituto Da Visao

São Paulo, 04038-032, Brazil
IRCCS San Raffaele

Milan, 20132, Italy
Instituto Oftalmologico Gomez-Ulla

Santiago de Compostela, 15706, Spain
Instituto Oftalmologico de Cordoba

Córdoba, 5000, Argentina
Ivey Eye Institute

London, Ontario, N6A 4V2, Canada
Jacobs Retina Center, UCSD

La Jolla, California, 92093, United States
Kings College Hospital NHS Trust

London, London, SE5 9RS, United Kingdom
Klinikum der Stadt Ludwigshafen gGmbH

Ludwigshafen, 67063, Germany
Klinikum rechts der Isar

München, 81675, Germany
Lions Eye Institute

Nedlands, 6009, Australia
London Vision Clinic

London, W1G 7LA, United Kingdom
Long Island Vitreoretinal Consultants

Great Neck, New York, 11021, United States
Maison Rouge Ophthalmologic Center

Strasbourg, 67000, France
Marsden Eye Specialist

Parramatta, New South Wales, 2150, Australia
Medical Center Ophthalmology Associates

San Antonio, Texas, 78240, United States
Michigan Medicine Kellogg Eye Center

Ann Arbor, Michigan, 48105, United States
Microcirujia Ocular Rosario

Rosario, 2000, Argentina
Mid Atlantic Retina

Bethlehem, Pennsylvania, 18107, United States
Mid Atlantic Retina

Philadelphia, Pennsylvania, 19006, United States
Mid Atlantic Retina

Philadelphia, Pennsylvania, 19107, United States
Mid Atlantic Retina Specialist

Hagerstown, Maryland, 21740, United States
Midwest Eye Institute

Indianapolis, Indiana, 46290, United States
NJ Retina

Teaneck, New Jersey, 07666, United States
NJ Retina

Toms River, New Jersey, 08755, United States
National Opthalmic Research Institute

Fort Myers, Florida, 33912, United States
New England Retina Consultants, PC

Springfield, Massachusetts, 01107, United States
Northern California Retina Vitreous Associates

Mountain View, California, 94040, United States
Northwestern Feinberg School of Medicine

Chicago, Illinois, 60611, United States
OFTAR

Mendoza, 5500, Argentina
Oculomedica Eye Centre

Tarnów, 33-100, Poland
Oftalmika Eye Hospital

Bydgoszcz, 85-631, Poland
Oftalmologos Especialistas

Santa Fe, S2000, Argentina
Ophthalmic Consultants of Boston

Boston, Massachusetts, 02114, United States
Ophthalmic Consultants of Long Island

Oceanside, New York, 11572, United States
Orange County Retina Medical Group

Santa Ana, California, 92705, United States
Oregon Retina LLP

Eugene, Oregon, 97405, United States
Organizacion Medica de Investigacion (OMI)

Buenos Aires, C1015 ABO, Argentina
Oxford Eye Hospital

Oxford, OX3 9DU, United Kingdom
Palm Beach Gardens

Palm Beach Gardens, Florida, 33418, United States
Pinnacle Research Insitute

Fort Lauderdale, Florida, 33309, United States
Radboud university medical center Oogheelkunde

Nijmegen, 6525 EX, Netherlands
Rambam Health Care Campus

Haifa, 3109601, Israel
Retina Associates of Cleveland

Cleveland, Ohio, 44130, United States
Retina Associates of Cleveland, Inc.

Cleveland, Ohio, 44122, United States
Retina Associates of Cleveland, Inc.

Youngstown, Ohio, 44505, United States
Retina Associates of Florida

Tampa, Florida, 33609, United States
Retina Associates of South Texas

San Antonio, Texas, 78240, United States
Retina Associates of Utah, PC

Murray, Utah, 84107, United States
Retina Center of NJ, LLC

Bloomfield, New Jersey, 07003, United States
Retina Centre of Ottawa

Ottawa, Ontario, K2B 7E9, Canada
Retina Consultants San Diego

Poway, California, 92064, United States
Retina Consultants of Houston

The Woodlands, Texas, 77384, United States
Retina Consultants of Houston, PA

Houston, Texas, 77030, United States
Retina Consultants of Orange County

Fullerton, California, 92835, United States
Retina Group of New England - New London

Waterford, Connecticut, 06835, United States
Retina Health Center

Fort Myers, Florida, 33907, United States
Retina Health Center

Madison, Wisconsin, 53705, United States
Retina Institute of California Medical Group

Palm Desert, California, 92260, United States
Retina Northwest, PC

Portland, Oregon, 97221, United States
Retina Research Center PLLC

Austin, Texas, 78750, United States
Retina Specialty Institute

Pensacola, Florida, 32503, United States
Retina Vitreous Center, PLLC

Edmond, Oklahoma, 73013, United States
Retina Vitreous Consultants

Monroeville, Pennsylvania, 15146, United States
Retina and Eye Consultantss

Hurstville, 2220, Australia
Retina and Vitreous Associates of Kentucky, PSC dba Retina Associates of Kentucky

Lexington, Kentucky, 40509, United States
Retina-Vitreous Associates Medical Group

Madison, Wisconsin, 53705, United States
Retinal Diagnostic Center

Campbell, California, 95508, United States
Retinal Research Institue, LLC

Phoenix, Arizona, 85014, United States
Royal Liverpool University Hospital

Liverpool, L7 8XP, United Kingdom
Rush University Medical Center

Chicago, Illinois, 60612, United States
STZ Eyetrial

Tübingen, 72076, Germany
Save Sight Institute

Westmead, 2145, Australia
Sierra Eye Associates

Reno, Nevada, 89503, United States
Southeast Retina Center, PC

Augusta, Georgia, 30909, United States
Southern Eye Specialists

Christchurch, 8013, New Zealand
Southwest Retina Research Center, LLC

Durango, Colorado, 81301, United States
Spokane Eye Clinical Research

Spokane, Washington, 99204, United States
St James's University Hospital

Leeds, West Yorkshire, LS9 7TF, United Kingdom
Strathfield Retina Clinic

Strathfield, New South Wales, 2135, Australia
Sunderland Eye Infirmary

Sunderland, SR2 9HP, United Kingdom
Sydney Retina

Sydney, New South Wales, 2000, Australia
Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel
Tennessee Retina, PC

Nashville, Tennessee, 78503, United States
Texas Retina Associates

Dallas, Texas, 75231, United States
The Ashley Centre

Westmead, New South Wales, 2145, Australia
The Ohio State University

Columbus, Ohio, 43212, United States
The Retina Care Center

Baltimore, Maryland, 21209, United States
The Retina Group of Washington

Chevy Chase, Maryland, 92705, United States
The Retina Group of Washington

Fairfax, Virginia, 22031, United States
The Retina Partners

Encino, California, 91436, United States
Tufts Medical Center

Boston, Massachusetts, 02116, United States
UNO-MED Centrum Medyne

Tarnów, 33-100, Poland
Uni-medizin Gottingen Augenklinik 3.B1.261

Göttingen, 37075, Germany
Uniklinik Koln

Cologne, 50937, Germany
Universitats-Augenklinik Bonn

Bonn, 53127, Germany
Universitatsklinikum Munster

Münster, 48149, Germany
Universitatsklinikum Regensburg

Münster, 48145, Germany
Universitatsklinikum Schleswig-Holstein

Lübeck, 23538, Germany
University Opthalmology Clinic

Freiburg im Breisgau, 79106, Germany
University hospital Kralovske Vinohrady

Prague, 10034, Czechia
University of Ottawa Eye Institute

Ottawa, Ontario, K1H 8L6, Canada
University of South Florida

Tampa, Florida, 33612, United States
University of Utah - John A. Moran Center

Salt Lake City, Utah, 84312, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
Valley Retina Institute

McAllen, Texas, 78503, United States
Vision Research Center Eye Associates of NM

Albuquerque, New Mexico, 87109, United States
Vitreoretinal Associates of Washington

Bellevue, Washington, 98004, United States
Vitreoretinal Surgery

Minneapolis, Minnesota, 55435, United States
Vitreous Retina Macula Consultants of New York

New York, New York, 10022, United States
Vseobecna fakultni nemocnice v Praze

Prague, 2128 08, Czechia
Western Carolina Retinal Associates

Asheville, North Carolina, 28803, United States

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