LSD study reveals how tiny doses alter perception and choices
NCT ID NCT05976698
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how low doses of LSD change the way healthy adults make decisions based on what they see. Thirty participants completed computer tasks that tested their ability to predict and respond to visual patterns. The goal was to understand how LSD influences brain signals involved in learning and perception.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Feb 2024
- Finished
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Feb 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Willingness to adhere to the study protocol and sign the consent form * ≥ 18 and ≤ 65 years of age at Screening * Body mass index 18-29 * Fluent understanding of German * Normal or corrected-to-normal vision * Willingness to not operate a traffic vehicle or heavy machinery 24 hours after substance administration * Willingness to refrain from taking illicit psychoactive substances, including cannabis, for the duration of the study * Willingness to not consume more than one alcoholic standard drink the night before the study sessions and not consume alcohol for 24 h after each study session * Willingness to abstain from xanthine-based liquids from the evenings prior to the study sessions and during the sessions * Willingness to use effective birth-control throughout the study duration * Adequate task performance in the decision-making tasks during a practice session in the screening visit Exclusion Criteria: * Recent (\<30 days) or current participation in another clinical trial * Women that are pregnant, nursing, or planning to become pregnant during the study period * Current use of contraindicated/psychoactive medications or illicit drugs * Lifetime use of classical psychedelics more than 20 times, or any time within the previous two months * Consumption of \>5 cigarettes per day or \>20 alcoholic standard drinks per week * Severe chronic or acute medical condition * Hypertension (\>140/90 mmHg) or hypotension (\<85mmHg systolic) * Current or lifetime major mental health disorder * Personal or family (first-degree) history of a primary psychotic disorder
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Psychiatric Clinics Basel
Basel, 4002, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.