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Brain zaps could silence voices that drugs Can't stop

NCT ID NCT01373866

Symptom relief Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a non-invasive brain stimulation technique called rTMS, guided by MRI scans, could reduce severe hallucinations in people with schizophrenia who don't respond to medication. 85 participants received either MRI-guided or standard rTMS over 5 days. The goal was to see if personalized targeting improves symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could offer a non-drug option to ease hallucinations in people with schizophrenia who don't respond to medication.
What could go wrong
This is a small, completed trial with 85 people. Results may not apply to everyone, and the effect might be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

85 people

The number who actually took part.

Started

Nov 2010

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Right-handed Female/Male, \[13-60 y.o.\], * Schizophrenia (DSM-IV-TR diagnosis), * Drug-resistant hallucinations (Kinon \& Kane criteria, 1993), * Unmodified antipsychotic dosage during the 30 days preceding rMTS, * No anticonvulsive medication, * No neurological disorder, no addictive behavior, * Matched for sex, age and PANSS scores, * Consent to participate to the study, Exclusion Criteria: * Pregnancy * Contraindication to MRI scan * Contraindication to rTMS treatment * Claustrophobia * No social insurance

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Conditions

The condition(s) this trial relates to.

Hallucinations perceptual disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hallucinations Perceptual disorders Schizophrenia

Contacts and locations

Locations

  • Lille University Hospital Centre

    Lille, F-59037, France

  • Saint-Anne Psychiatric Hospital

    Paris, 75005, France

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