Computer-Controlled sedation may protect elderly brains after surgery
NCT ID NCT07311447
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 50 older adults (65+) having major surgery to see if using a computer-controlled sedation method (target-controlled infusion, or TCI) helps protect thinking and memory after the operation. Participants were split into two groups: one received TCI and the other received manual sedation. Their cognitive function was tested before and after surgery. The goal is to find safer ways to sedate elderly patients and reduce the risk of confusion or memory problems after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- target-controlled infusion (TCI) of sedatives and analgesics
- What this could lead to
- If successful, this could point toward safer sedation methods that reduce cognitive decline after surgery in older adults.
- What could go wrong
- This is a small, completed observational study with only 50 participants, so results may not apply broadly. It does not test a new drug or treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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50 people
The number who actually took part.
- Started
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May 2025
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Geriatric patients aged 65 years and older who undergo noncardiac, nonneurosurgical major surgery under general anesthesia and are monitored postoperatively in the intensive care unit. The study includes patients managed with either Target Controlled Infusion (TCI) or manual infusion for postoperative sedation and analgesia.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 65 years and older * Undergoing noncardiac, nonneurosurgical major surgery under general anesthesia * Monitored postoperatively in the intensive care unit * Provided informed consent to participate in the study Exclusion Criteria: * Cardiac or neurosurgical procedures * Patients younger than 65 years * Glasgow Coma Scale \< 8 * No informed consent * Body mass index (BMI) \> 35 * Communication difficulties preventing cognitive testing * Known allergy to study medications
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
İstanbul Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Mapping the waking brain: how ICU patients emerge from sedation