Which opioid is best for ventilated ICU patients? new trial aims to find out
NCT ID NCT07224620
First seen Nov 06, 2025 · Last updated Jun 19, 2026 · Updated 34 times
Summary
This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide standard care for critically ill patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fentanyl and hydromorphone (opioid painkillers)
What this could lead to
If one drug proves superior, it could become the preferred choice for sedating ventilated ICU patients, potentially improving outcomes and reducing opioid use.
What could go wrong
This is a small pilot study (300 patients) at a single hospital, so results may not apply broadly. Both drugs are already standard care, so no breakthrough is expected.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.