Beth Israel Deaconess Medical Center

This study tests whether a short course of the steroid hydrocortisone can reduce inflammation and improve outcomes for people with severe pancreatitis. Researchers will give the drug or a placebo to 86 ICU patients and track their organ failure scores and hospital stay length. Th…

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach …

This pilot study tests a surgical procedure for people with severe emphysema or COPD who did not get enough benefit from a standard valve treatment. The surgery uses small incisions to complete the fissures between lung lobes and remove scar tissue, aiming to improve lung functio…

This study tests whether adding raloxifene (a drug used for bone health) to finasteride (a standard BPH drug) works better than finasteride alone for men with an enlarged prostate. About 242 adults will take either the combo or finasteride plus a placebo for 12 months. The main g…

This Phase 3 trial is testing whether people who were taking statins before a brain hemorrhage should continue or stop them afterward. Researchers will also check if a person's APOE gene affects the risk. The study plans to enroll 1,456 participants aged 50 and older who had a sp…

This study tests whether completing the gaps between lung lobes with surgery before placing standard lung valves can improve outcomes for people with severe emphysema or COPD. About 20 participants will either receive the combined procedure or standard medical care. The goal is t…

This study tests whether delivering healthy DASH-diet groceries and dietitian support to people with high blood pressure in Florida, Georgia, and Tennessee can lower their blood pressure. About 150 adults with elevated blood pressure will receive all their groceries for 4 weeks. …

This study tests a flexible microwave probe that can be guided through a bronchoscope to destroy small lung cancer nodules (up to 3 cm). Ten people with early-stage lung cancer will receive the procedure, and researchers will check if it works as planned and how much tumor tissue…

This study tests whether the drug epcoritamab can help people with follicular lymphoma who still have signs of cancer after their first round of chemoimmunotherapy. About 35 adults with advanced-stage disease will receive epcoritamab as a second treatment. The main goal is to see…

This study tests whether grafts modified by doctors during surgery can safely repair complex aortic aneurysms in patients who are too high-risk for standard surgery. About 220 participants with different types of aortic damage will be followed for up to 5 years to check survival,…

This study is testing a new combination of treatments—radiation beads, immunotherapy, and chemotherapy—for people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this triple therapy can slow or stop the cancer from growing. About 30 adults …

This study compares high flow oxygen to standard oxygen for adults with dangerously low blood oxygen (acute hypoxemia) in five East African hospitals. Researchers want to see if high flow oxygen lowers death rates and uses oxygen more efficiently. About 1,600 participants will be…

This study is testing a handheld device called mScan that uses a tiny, painless electrical current to measure muscle health. Researchers want to see if it can give similar results to an MRI, but faster and more conveniently. The study involves 150 adults with and without muscle d…

This study tests a simple program for people aged 60+ having heart surgery. Before surgery, participants will get help improving sleep and do brain exercises. After surgery, they receive extra pain relief. The goal is to see if this bundle reduces delirium (sudden confusion and a…

This study tests a program called Doula Link, which gives doulas extra training and tools to support the mental health of pregnant and new mothers. Researchers will compare doulas who receive this training to those who continue their usual care. The goal is to see if the program …

This study tests whether a gentle, non-invasive brain stimulation technique called HD-tDCS can improve word-finding and memory problems in people who have had a traumatic brain injury (TBI) at least one year ago. Researchers will give 24 participants either real or fake (sham) st…

This study tests a medicated foam (roflumilast) applied to the skin for hidradenitis suppurativa, a condition causing painful bumps and abscesses. About 20 adults with mild to moderate HS will use the foam for 16 weeks. The goal is to see if it reduces the number of inflamed nodu…

This study tests whether mind-body techniques can reduce symptoms like pain, fatigue, and dizziness in people with Long COVID. About 180 adults will be randomly assigned to a mind-body program, a different mind-body approach, or usual care. The goal is to see if these techniques …

This study tests a new, non-invasive treatment for people with drug-resistant epilepsy, whose seizures are not controlled by medication. The treatment uses infrared light, which has reduced seizures in animal studies, to see if it can safely do the same in humans. Researchers wil…

This study tests whether massaging the perineal muscles with a pelvic wand during late pregnancy and labor helps women feel more in control during childbirth and improves pelvic recovery. About 140 pregnant women planning to give birth at Beth Israel Deaconess Medical Center will…

This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult…

This study is testing a new approach to help people aged 60 and older who have mild cognitive impairment (MCI) and insomnia. It combines a gentle brain stimulation technique called transcranial magnetic stimulation (TMS) with an internet-based cognitive behavioral therapy program…

This study looks at whether dry needling can reduce pain from trigger points (tight, tender spots) in the trapezius muscle, which runs from the neck to the shoulders. About 70 adults with myofascial pain will receive either dry needling or a placebo treatment. Researchers will us…

This small study is testing a mind-body program for adults who have chronic migraines (at least 5 headache days per month). The goal is to see if the program is practical and helpful for reducing migraine-related disability and improving quality of life. Participants will attend …

This study tests whether letting men control their own nitrous oxide (laughing gas) during a vasectomy can lower pain and anxiety. About 35 men scheduled for a vasectomy will use a mask to adjust their gas level as needed. The goal is to see if this approach improves comfort and …

This study looks at whether a mind-body program can help people with long-term back pain feel better and move more easily. About 150 adults with chronic back pain will be randomly assigned to the mind-body program, a different mind-body approach, or their usual care. The goal is …

This study tests whether using ultrasound to guide a numbing injection (hematoma block) works better than the traditional method of injecting without imaging for people with a broken wrist. About 115 adults in the emergency department will take part. The goal is to see which appr…

This study tests a new way to treat persistent air leaks (PALs) in the lungs, a condition that can keep people in the hospital for a long time. About 20 adults who cannot have surgery will get a combination of a blood patch and a tiny valve placed in the airway during a scope pro…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This pilot study is testing whether a mind-body intervention can improve daily function and reduce pain in 40 adults with chronic upper extremity pain (like repetitive stress injury). Participants will learn mental techniques to manage pain and will be followed for changes in arm…

This study tests whether injecting a small amount of saline into the spinal fluid can quickly reverse leg weakness caused by spinal anesthesia after joint replacement surgery. About 20 adults having elective lower extremity joint replacement will receive the saline through a tiny…

This observational study is testing whether non-invasive monitors that track brain electrical activity and oxygen levels can help determine the best blood pressure to maintain during major non-cardiac surgery in people over 60. The goal is to see if these monitors can reliably gu…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study looks at brown fat, a type of body fat that burns energy to produce heat, and compares it to white fat, which stores energy. Researchers will collect fat samples from 40 healthy adults during planned surgeries and analyze them to understand how brown fat works. The goa…

This study screens healthy adults aged 18 and older to see if they qualify for future infectious disease vaccine or treatment trials. It collects basic information like race, ethnicity, and gender to help researchers quickly find suitable volunteers. No treatment is given—this is…

This study is a registry that follows 500 people with early Alzheimer's disease who are receiving anti-amyloid antibody therapy. Researchers will track how well the treatment slows cognitive and functional decline, monitor side effects, and see how long benefits last. The goal is…

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause. Researchers want to understand why some women feel depressed during this time. The study involves 80 healthy women aged 40 to 60 who have depressiv…

This study looks at how sleep apnea impacts people with multiple sclerosis (MS). Researchers will collect sleep data, brain scans, and medical records from 800 adults with MS to see if sleep apnea is linked to worse MS symptoms or brain changes. The goal is to better understand t…

This study tests whether a decision aid and training for surgeons can help women aged 70 and older with low-risk stage I breast cancer make better treatment choices. About 402 participants will be split into two groups: one where surgeons get shared decision-making training and p…

This study aims to understand why some men with an enlarged prostate (BPH) do not respond to the common drug finasteride. Researchers will follow 120 men starting finasteride, tracking their symptoms and using MRI scans and genetic tests over three years. The goal is to find ways…

This study is screening up to 1,395 adults who are at higher risk for pancreatic cancer to see if early detection can find treatable tumors or precancerous growths. Participants will undergo imaging and follow-up based on standard guidelines. The goal is to improve early diagnosi…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a sports drink. It includes women with and without epidural pain relief. The goal is to understand digestion during labor, not to test a treatment.

This study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 patients undergoing cardiac surgery to study how estrogen loss affects heart energy and blood vessel health. The goal is to better understand…

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This early-phase study looks at how heat stress changes kidney function in 28 healthy, fit volunteers. Researchers want to understand the body's chemical responses and whether taking vitamin B3 (niacinamide) can influence those changes. The goal is to gather knowledge, not to tre…

This study is testing a device called the mScan to see if it can track how ALS progresses over time. Researchers will measure electrical signals in muscles and compare them to standard tests. The goal is to find a simple, objective way to monitor the disease that could be used at…

This study is looking for ways to detect early signs of serious infection, like sepsis, using simple blood tests. Researchers will follow 4200 adults with and without infections to see if certain markers can predict who is at risk for death or organ failure. The goal is to help d…

This study tests if low-cost, single-use bronchoscopes (thin tubes used to look inside the lungs) can safely replace reusable ones for routine lung procedures. About 20 adults will undergo a lung exam with the disposable scope. Doctors will rate the scope's quality, handling, and…

This study uses special imaging to map the lymphatic system in the arms of healthy women and breast cancer survivors who did not develop swelling (lymphedema). The goal is to learn how these alternate pathways work and why some people avoid lymphedema after lymph node removal. Ab…

This study looks at whether transferring embryos after 3 days or 5 days leads to more live births in IVF patients who have 5 or fewer embryos. About 1,126 people will take part, and researchers will also track patient satisfaction and complications. The goal is to help doctors an…

This study looks at whether using remote alerts from heart devices (like pacemakers or defibrillators) can lead to better care than the usual guidelines. About 120 adults with these devices will be randomly assigned to one of two monitoring approaches. The goal is to see which me…

This study looks at how not getting enough sleep or having insomnia changes the way people handle their emotions. Researchers will compare three groups: people who sleep only 4 hours for three nights, people with insomnia, and healthy sleepers. Participants will do emotion tasks …

This study tests whether a simple, step-by-step guide (called a linear cognitive aid) helps emergency medical teams treat children in life-threatening situations. About 80 EMS providers will use the guide during realistic practice scenarios. The goal is to see if the guide is eas…