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Oxygen showdown: can high flow save more lives in east africa?

NCT ID NCT05754034

Disease control Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 8 times

Summary

This study compares high flow oxygen to standard oxygen for adults with dangerously low blood oxygen (acute hypoxemia) in five East African hospitals. Researchers want to see if high flow oxygen lowers death rates and uses oxygen more efficiently. About 1,600 participants will be randomly assigned to one of the two oxygen methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age\>=18 years AND * admitted to a study site hospital within the 24 hours prior to screening AND * SpO2\<90% at time of first assessment OR * receiving oxygen at time of first assessment Exclusion Criteria: * imminent death (high clinical suspicion of death within 24 hours of admission) * patient or caregiver refusal of study participation * history of chronic respiratory failure (SpO2\<90% or oxygen dependence for at least three months) * anatomical factors precluding the use of nasal cannula * intubation or non-invasive ventilation by the clinical team prior to screening for the trial * known hypoxemia at transferring facility for \>48 hours * lack of availability of either SFO or HFO devices or supplies at the time of randomization.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute hypoxemia

Contacts and locations

Locations

  • AIC Kijabe Hospital

    Kijabe, Kenya

  • Nakuru Level V Hospital

    Nakuru, Kenya

  • Queen Elizabeth Central Hospital

    Blantyre, Malawi

  • The University Teaching Hospital of Butare (CHUB)

    Huye, Rwanda

  • The University Teaching Hospital of Kigali (CHUK)

    Kigali, Rwanda