Beth Israel Deaconess Medical Center

This study tests a personalized vaccine made from a patient's own leukemia cells and immune cells. The goal is to see if the vaccine can help prevent the cancer from coming back after chemotherapy. It is for adults aged 55 and older with acute myeloid leukemia (AML) who are in re…

This phase 2 study tests nivolumab (Opdivo) in 29 men with high-risk prostate cancer that has returned after initial treatment, shown by rising PSA levels. The drug works by helping the immune system recognize and attack cancer cells. The main goal is to see if nivolumab can cont…

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study tests whether providing home-delivered DASH diet groceries, with help from a dietitian, can lower blood pressure in Black adults who already take medication for hypertension. Participants live in Boston-area neighborhoods with limited access to healthy food. The trial …

This phase II trial is testing a higher dose (500 mg) of the drug fulvestrant (Faslodex) as a first hormonal treatment for postmenopausal women with hormone receptor positive metastatic breast cancer. The study aims to see if this higher dose improves clinical benefit compared to…

This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide s…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This early-phase study tests a custom-made cancer vaccine (DC/AML fusion vaccine) for people with acute myeloid leukemia (AML) who have recently had a stem cell transplant. The vaccine is designed to teach the body's immune cells to recognize and attack remaining leukemia cells. …

This study tests a drug called olaparib in people with metastatic breast cancer that has spread beyond the breast. Participants must have a specific gene change in their tumor that may make it sensitive to this drug. The goal is to see if olaparib can shrink tumors or slow cancer…

This observational study tests three non-invasive technologies—ultrasound, electrical impedance, and nerve excitability tests—to see if they can reliably diagnose myofascial pain syndrome. Researchers will compare results from 90 people with and without the condition. The goal is…

This study is testing a computer model called PRISM that uses electronic health records to predict who might develop pancreatic cancer. Researchers will analyze data from over 6 million people aged 40 and older across 44 US healthcare centers. The goal is to see if the model can …

This study looks at how well a two-step cervical cancer screening process works in Botswana. It uses an HPV test first, followed by a visual exam, to find early signs of cancer. About 3,000 women aged 25 and older, including those living with HIV, will take part. The goal is to f…

This study looks at whether long-acting HIV prevention shots (CAB-LA) are safe and work well for breastfeeding mothers after childbirth. About 500 new mothers in Botswana will get the shots and be followed for 24 months along with their babies. The goal is to see if this method c…

This phase 2a trial tests whether the drug abrocitinib can reduce severe fatigue in adults with Long COVID. About 46 people who were never hospitalized for COVID but now have long-term fatigue will take either 50 mg, 100 mg of abrocitinib, or a placebo daily for 12 weeks. Researc…

This study tests a simple checklist called CMOT (Comfort Measures Only Time Out) for ICU teams. The goal is to reduce distress in patients when breathing machines are removed at the end of life. Researchers will enroll 184 patients and their care teams across four ICUs to see if …

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or at high risk for psychosi…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite and food cravings. About 28 obese adults will have brain scans before and after treatment to see how the drug affects hunger-control centers. The goal is to better unders…

This study aimed to see if a four-session biofeedback training program could improve trunk control and walking patterns in older adults with and without chronic low back pain. Researchers planned to compare 20 older adults with back pain to 20 healthy volunteers. However, the stu…

This study reviewed records of 70,000 adults who had non-urinary surgery under general anesthesia. It compared two drugs used to reverse muscle relaxants: sugammadex and neostigmine (given with atropine or glycopyrrolate). The goal was to see which drug is linked to fewer cases o…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study looks at how well air and blood mix in the lungs of 10 adults on a heart-lung bypass machine called VA ECMO. Researchers will adjust the ventilator pressure and use special monitors to see if they can improve oxygen levels. The goal is to learn more about lung function…

This study looks at whether a short course of hormone therapy can make prostate cancer cells more visible on PSMA PET scans in men whose cancer has returned after initial treatment. About 9 participants will take standard hormone pills for 4 weeks and then get a scan to see if ne…

This pilot study tests whether a gentler, low-intensity breathing support method during robotic surgery can reduce lung collapse and breathing complications after surgery. About 60 adults having robot-assisted abdominal or pelvic surgery will be randomly assigned to either the ne…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study looks at whether a new, less invasive way to measure bone tissue properties can better identify women at risk for hip and wrist fractures. Researchers will compare these measurements to standard bone density tests. The goal is to improve fracture risk assessment beyond…

This study follows 500 adults over age 65 who are getting a new implantable defibrillator (ICD) for the first time. Researchers will track their health, daily function, and quality of life for 18 months, with optional follow-up up to 10 years. The goal is to better understand how…

This study checks if a computer model called LIRIC can accurately predict who will develop liver cancer using electronic health records. Researchers will track 6 million adults aged 40 and older without a history of liver cancer to see how well the model works. The goal is to imp…