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New ICU checklist aims to make final moments more comfortable

NCT ID NCT05861323

Symptom relief Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a structured team checklist called CMOT for when breathing support is removed from dying ICU patients. The goal is to reduce distress, which occurs in 30-59% of cases. Researchers will enroll 184 patients and ICU staff across four ICUs to see if the checklist is practical and helpful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Comfort Measures Only Time Out (CMOT) checklist
What this could lead to
If it works, this could provide a simple tool to reduce suffering for patients dying in the ICU.
What could go wrong
This is a small early feasibility study, not a large trial. It may not show clear benefit or be practical in all ICUs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 184 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Patient Inclusion Criteria * Age ≥ 18 * Decision made for withdrawal of mechanical ventilation (WMV) by patient/surrogate and ICU team * WMV has not yet occurred Patient Exclusion Criteria • None ICU Clinician Inclusion Criteria: * ICU nurse, Physician/Advance Practice Provider, or respiratory therapist * Age ≥ 18 * Providing direct care to WMV patient for at least 1-hour pre-extubation ICU Clinician Exclusion criteria: • Unable to communicate in English

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Conditions

The condition(s) this trial relates to.

Coma Death Hypoventilation ocular motor apraxia, Cogan type respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging COMA End of life Respiratory failure Ventilatory failure

Contacts and locations

Locations

  • Beth Israel Deaconess Medical center

    Boston, Massachusetts, 02215, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.