Beth Israel Deaconess Medical Center

This study tested a new vaccine made by fusing a patient's own immune cells with their tumor cells. The goal was to see if it is safe and can boost the immune system to attack advanced melanoma. Twenty adults with progressive, measurable metastatic melanoma received the vaccine. …

This study tested a new type of vaccine for people with stage IV kidney cancer. The vaccine was made by mixing a patient's own tumor cells with immune cells from a healthy donor. The goal was to see if the vaccine was safe and if it could help the immune system fight the cancer. …

This study tested whether adding an experimental antibody (CT-011) and a personalized cancer vaccine after a stem cell transplant could help the immune system fight multiple myeloma and delay the cancer's return. 35 adults with multiple myeloma took part. The goal was to see if t…

This early-phase trial tested a personalized vaccine for people with advanced kidney cancer. The vaccine was made by fusing a patient's own immune cells with their tumor cells, aiming to train the body to attack the cancer. The main goals were to check safety and see if the vacci…

This study tested a new device that checks for anemia (low red blood cells) in pregnant women without needing a blood draw. Anemia is common in pregnancy and can cause problems during delivery if not caught early. The device uses a sensor on the skin to measure hemoglobin levels,…

This study tested a new blood test that measures platelet activity and compared it to the current standard test. Researchers gave aspirin and clopidogrel to 112 healthy and severely obese volunteers to see how accurate the new test is. The goal is to find a simpler, faster way to…

This study tested whether giving older adults (60+) a common painkiller (acetaminophen) through an IV every 6 hours during heart surgery could prevent postoperative delirium—a state of sudden confusion that often occurs after major operations. Researchers enrolled 900 patients un…

This study tested whether multi-port epidural catheters provide better pain relief than single-port catheters after chest or upper abdomen surgery. 240 adults took part. The main goal was to see how often each type failed and required extra pain medicine or replacement.

This study tested whether suvorexant, a sleep medication, could improve sleep and reduce delirium (sudden confusion) in 100 adults aged 60 and older recovering from heart surgery in the intensive care unit (ICU). Participants received either suvorexant or a placebo for 7 nights. …

This study tested whether a gentle electrical current applied to the brain could help reduce symptoms of mania in people with bipolar disorder. Fourteen adults with mild to moderate mania received the stimulation. The goal was to see if targeting specific brain areas linked to ma…

This study tested whether using a high-flow nasal oxygen device during upper endoscopy (a scope exam of the stomach and intestines) can prevent dangerous drops in blood oxygen levels in patients at high risk. 180 adults with conditions like sleep apnea or obesity were randomly as…

This study tested if a special eye-controlled communication device (EyeControl-Pro) could reduce delirium in older adults (age 50+) who are on breathing machines in the ICU. Delirium is a state of confusion that often happens in the hospital. The study involved 160 patients and c…

This study compared two common anti-nausea drugs, dexamethasone and ondansetron, in 100 healthy women having a planned or non-labor cesarean delivery. The goal was to see which medication works better as a first-line treatment to prevent postoperative nausea and vomiting. Researc…

This study tested a special anesthesia method during heart surgery to help older adults recover better. The goal was to reduce confusion, pain, and blood pressure problems after surgery. 70 people aged 60 and older who had heart bypass or valve surgery took part. The approach use…

This study tested a daily synbiotic (a mix of probiotics and prebiotics) called DS-01 in 48 adults with irritable bowel syndrome (IBS). The goal was to see if it is safe and helps improve gut barrier function and digestive symptoms compared to a placebo. Participants took the sup…

This study tested whether an ultrasound-guided nerve block (a numbing injection near the hip) works as well as standard opioid painkillers for people with a hip fracture in the emergency department. 44 adults with moderate to severe pain took part. Researchers measured pain relie…

This study tested whether self-administered nitrous oxide (laughing gas) can reduce pain and anxiety during a urodynamic study (UDS), a test for urinary symptoms. Nineteen adults scheduled for UDS received low-dose nitrous oxide during the procedure. Researchers measured bladder …

This small study tested whether a noninvasive electrical stimulation technique, aimed at a specific brain area called the right superior temporal sulcus, could help reduce hallucinations in people with psychosis. Twelve adults who were actively experiencing hallucinations receive…

This study tested a brief cognitive behavioral therapy (CBT) program to help older adults (55 and older) reduce or stop taking benzodiazepines, which are often used for anxiety or sleep problems. Seventeen participants received the therapy and were followed to see if they could l…

This small pilot study looked at whether a 12-week tai chi program is practical and beneficial for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or their usual care. The study focused on whether tai chi cou…

This study looked at whether using ultrasound to guide epidural needle placement works better than the usual method of feeling for landmarks (palpation) in women experiencing labor pain. Researchers compared how often the catheter was placed at the right spot and how long the pro…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindful attention program, both, or neither. The go…

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to see if the drug changes brain structure in people with chronic migraine. 64 adults with frequent migraines took part to help scientists learn more about the d…

This study looked at whether giving patients less oxygen (70% or 40% instead of the usual 100%) just before removing their breathing tube after surgery could reduce lung collapse (atelectasis). 48 adults having elective surgery took part. Researchers used a special imaging tool (…

This study tested whether an AI system can safely have a medical conversation with patients before an urgent care visit. 100 adults seeking urgent care talked to the AI, supervised by a doctor who could step in if needed. The goal was to see if patients and doctors found the AI h…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Both are standard techniques used during screening. The goal was to learn which appr…

This study tested a program called InVEST that provides personalized support to help teens and young adults (ages 12-22) who are at high risk for psychosis improve their functioning in school or work. The study enrolled 26 participants and measured how feasible and acceptable the…

This study looked at whether long-term meditation practice is linked to a younger-looking brain and better sleep. About 108 adults (57 meditators and 51 non-meditators) wore sleep-tracking devices for five nights and took cognitive tests. Researchers compared brain age estimates …

This pilot study tested whether a multi-component prehabilitation program (physical therapy, nutrition counseling, and meditation) is feasible for high-risk older adults scheduled for major elective surgery. Thirty participants aged 70+ (or 65+ with high risk) were enrolled. The …