Beth Israel Deaconess Medical Center

This study tested a new type of vaccine made by fusing a patient's own immune cells with their cancer cells. The goal was to see if it was safe and could help the immune system fight advanced melanoma. Twenty adults with spreading melanoma that was getting worse took part. The va…

This study tested a personalized vaccine made from a patient's own tumor cells fused with immune cells (dendritic cells) to treat stage IV kidney cancer. The vaccine was given with a drug called GM-CSF to boost immune response. The main goal was to check safety and side effects i…

This study tested a drug called GO-203-2C, which targets a protein (MUC1) found in cancer cells, for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The drug was given alone or with another chemotherapy drug, decitabine, to 33 participan…

This study tested a new type of vaccine for people with stage IV kidney cancer. The vaccine was made by mixing a patient's own tumor cells with immune cells from a healthy donor. The goal was to see if this fusion cell vaccine is safe and whether it can help the immune system fig…

This study tested whether cisplatin, a platinum-based chemo, works better than the standard doxorubicin/cyclophosphamide (AC) combo in women with newly diagnosed breast cancer who carry a BRCA mutation. 118 participants received either cisplatin or AC before surgery. The main goa…

This study tested a drug called abatacept in 56 people with chronic graft-versus-host disease (cGVHD) that was not getting better with steroids. cGVHD happens when donor immune cells attack the patient's body after a stem cell transplant. Abatacept works by calming the immune sys…

This study tested whether delivering DASH diet groceries to the homes of Black adults in Boston-area food deserts could lower their blood pressure. Participants had elevated blood pressure but were not on medication. The goal was to see if better access to healthy food can help c…

This study tested whether zafirlukast, an asthma drug, can slow or stop ovarian cancer in people whose only sign of relapse is a rising CA-125 blood marker. Only 5 participants were enrolled. The main goal was to see if the drug could lower CA-125 levels by at least half for a mo…

This study tested whether adding an experimental antibody (CT-011) and a personalized cancer vaccine to standard stem cell transplant is safe and helps prevent multiple myeloma from coming back. 35 adults with multiple myeloma participated. The goal was to see if the combination …

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This study tested whether very low doses of a protein called IL-2, given as shots under the skin for 4 weeks, could increase the number of helpful immune cells (Tregs) in liver transplant recipients. The goal was to see if this approach might improve the body's acceptance of the …

This study tested a new blood test that measures how well platelets work in people taking common blood thinners like aspirin and clopidogrel. Researchers compared the new test to the current standard test in 112 healthy volunteers and severely obese individuals. The goal was to s…

This study tested a new imaging technique called restriction spectrum imaging (RSI) to see if it can find breast cancer as well as standard breast MRI. About 460 women who were getting routine breast cancer screening took part. The goal was to compare how accurate RSI is versus c…

This study tested a device that checks for anemia (low iron) in pregnant women without a blood draw. It included 124 pregnant or postpartum adults. The goal was to see if the non-invasive device gives the same results as standard blood tests.

This study tested whether giving older adults (60+) a common painkiller (IV acetaminophen) every 6 hours during heart surgery recovery could prevent delirium, a state of sudden confusion. The trial involved 900 participants across multiple hospitals. Researchers compared those wh…

This study tested a wearable eye-tracking device called EyeControl-Pro in 160 older, ventilated ICU patients. The device lets patients communicate by moving their eyes, which may help reduce delirium—a state of confusion common in intensive care. Researchers compared patients who…

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce delirium after heart surgery in the intensive care unit. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights after surger…

This completed study tested whether a gentle electrical current applied to a specific brain area (the right superior temporal sulcus) could reduce hallucinations in people with psychosis. Twelve adults who were actively experiencing hallucinations received the stimulation. The go…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study looked at 100 healthy women having a planned or non-labor cesarean delivery to see which drug works better as a first-line treatment to prevent nausea and vomiting after surgery. Participants received either dexamethasone or ondansetron, and researchers tracked how man…

This study tested whether using ultrasound to guide epidural needle placement works better than the traditional method of feeling for landmarks (palpation) in women with labor pain. About 110 healthy pregnant women received an epidural using either ultrasound or palpation. The go…

This study tested a non-invasive brain stimulation technique to reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen participants with mild-to-moderate mania received targeted electrical stimulation to brain areas linked to impulse control and risk-t…

This study looked at whether using high-flow nasal oxygen during upper endoscopy can prevent blood oxygen levels from dropping too low in high-risk patients. 180 adults who were at risk (due to sleep apnea, obesity, or other factors) took part. Half received standard care and hal…

This study tested whether multi-port epidural catheters provide better pain relief than single-port catheters after chest or upper abdomen surgery. 240 adults took part. The main goal was to see if multi-port catheters reduce the need for extra pain medicine or catheter replaceme…

This study tested whether an ultrasound-guided nerve block could control hip fracture pain as well as standard opioid injections. 44 adults with hip fractures in the emergency department took part. Researchers measured pain relief using a pain scale to compare the two methods.

This study tested a brain-wave-guided anesthesia method combined with a planned pain management approach in 70 older adults (age 60+) having heart surgery. The goal was to see if it could lower the risk of confusion, keep blood pressure stable, and reduce pain and opioid use afte…

This study tested a daily synbiotic supplement (DS-01) in 48 adults with irritable bowel syndrome (IBS) to see if it is safe and helps improve gut health. Participants took either the supplement or a placebo for 12 weeks. The main goal was to check for side effects and see how th…

This pilot study tested a brief cognitive behavioral therapy (CBT) program to help older adults (55+) reduce or stop their use of benzodiazepines, which are commonly prescribed for insomnia and anxiety but can be risky with age. Seventeen participants received up to three therapy…

This study tested whether giving low-dose nitrous oxide (laughing gas) during a urodynamic study (a test for urinary symptoms) changes key bladder measurements like capacity and pressure. 19 adults scheduled for the test took part. If the measurements stay the same, nitrous oxide…

This small pilot study looked at whether a 12-week tai chi program is practical and helpful for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or usual care. The study focused on whether tai chi could improv…

This study tested three different doses of spinal morphine (50, 150, or 250 micrograms) to see which provides the longest pain relief after a C-section. 72 healthy women participated, and researchers measured how long until they needed extra pain medication. The goal is to improv…

This study looked at whether a 15-minute meditation practice called Shoonya meditation can help people stay sharp after a night without sleep. Researchers compared regular meditators to people who nap regularly, measuring brain activity, heart rate, and cognitive performance. The…

This study looked at whether using a lower amount of oxygen (70% or 40%) instead of the usual 100% before removing a breathing tube after surgery could reduce lung collapse (atelectasis). 48 adults having elective surgery took part. The researchers measured lung function using a …

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study tested a program called InVEST that provides one-on-one support for young people aged 12 to 22 who are at high risk for psychosis. The goal was to see if the program helps them do better at work or school. The study had two parts: first a small test with 8 people to se…

This study tested a website designed to help doctors and women aged 75 to 89 talk about the pros and cons of mammograms. 155 participants used the tool to make more informed choices. The goal was to improve decision-making, not to cure or prevent breast cancer.

This study tested whether an artificial intelligence (AI) system could safely have a medical conversation with patients before they see their doctor for an urgent care visit. About 100 adults spoke with the AI less than a week before their appointment, while a doctor watched over…

This study looked at whether a 21-minute daily meditation practice called Shambhavi Mahamudra Kriya can improve brain health. Researchers measured brain activity, brain structure, and thinking skills in 77 adults over 6 months. The goal was to see if meditation leads to a calmer,…

This study looked at whether long-term meditation is linked to a younger 'brain age' and better sleep. Researchers compared 57 meditators who practice Shambhavi Mahamudra Kriya with 51 non-meditators. Participants wore EEG headbands and sleep rings at home for five nights to meas…

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to see if the drug changes brain structure in people with chronic migraine. The goal was to learn more about where the drug works, not to test if it helps sympto…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindfulness program, both, or neither. The goal was…

This pilot study tested whether a multi-component prehabilitation program—including physical therapy, nutrition counseling, and meditation—is feasible for older adults (70+ or 65+ with high risk) scheduled for major elective surgery. The program aimed to improve strength and reco…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…