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Which drug works best for Post-C-Section nausea? study pits dexamethasone against ondansetron

NCT ID NCT05692245

Symptom relief Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 100 healthy women having a planned or non-labor cesarean delivery to see which drug works better as a first-line treatment to prevent nausea and vomiting after surgery. Participants received either dexamethasone or ondansetron, and researchers tracked how many extra medications they needed for nausea, vomiting, itching, or pain in the first 24 hours. The goal is to find the most effective option to improve comfort after C-section.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone and ondansetron
What this could lead to
If successful, this could help doctors choose the best first-line antiemetic for women after cesarean delivery, improving recovery comfort.
What could go wrong
This is a small, completed Phase 4 trial with only 100 participants, so results may not apply to all patients. Both drugs are well-known, so no major surprises are expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

100 people

The number who actually took part.

Started

Mar 2023

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy women (ASA 2) * Between 18 and 45 years old * Singleton term pregnancies * Scheduled or non-labor cesarean delivery * Neuraxial (spinal or combined-spinal epidural) anesthesia Exclusion Criteria: * Refusal to participate * Known allergy or contraindication to any medication used in the study * Significant medical or obstetrical disease (ASA ≥ 3) * Antiemetic use within 24 hours preceding cesarean delivery * Insulin dependent diabetes * Hyperemesis gravidarum or chronic antiemetic use * History of daily or near-daily steroid use during pregnancy * Opioid use disorder or other chronic pain syndrome * Opioid use during pregnancy * Use of antipruritus medication, pruritic urticarial papules of pregnancy, or cholestasis of pregnancy

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section complications Nausea and vomiting, postoperative

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.