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Electric brain zap tames mania in small trial

NCT ID NCT05445466

First seen Nov 06, 2025 · Last updated Jun 17, 2026 · Updated 27 times

Summary

This study tested a non-invasive brain stimulation technique to reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen participants with mild-to-moderate mania received targeted electrical stimulation to brain areas linked to impulse control and risk-taking. The goal was to see if this approach could safely lower manic symptoms without the side effects of standard medications.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

Conditions

The condition(s) this trial relates to.

bipolar disorder Mania Psychotic Disorders schizoaffective disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.