GASTRIC CANCER

This is a first-in-human study testing a new oral drug called NX-1607 in adults with advanced cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body handles the drug, both alone and combined with a common chemot…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This study is testing two different combinations of new drugs for people with stomach or gastroesophageal junction cancer who haven't had treatment yet. Researchers want to see if these drug combinations can shrink tumors effectively and are safe for patients. The trial will meas…

This study is testing whether sorbitol, a common sugar alcohol, can improve the effectiveness of standard chemotherapy and immunotherapy for locally advanced stomach cancer. Researchers will compare sorbitol against a placebo in 80 patients who will receive the treatment for 3 mo…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This study is testing whether using MRI scans during radiation treatment can help doctors target cancer more precisely while patients receive chemotherapy. Researchers want to see if this approach is safe and practical for treating gastric and breast cancers. The study involves 7…

This early-stage study is testing a new drug called BL-M17D1 in adults with advanced gastrointestinal cancers and other solid tumors that have a specific marker called HER2. The main goal is to find the safest dose and see how the body processes the drug. Researchers will also ch…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This large Phase 3 trial is testing if washing the abdomen with heated chemotherapy during surgery helps people with advanced stomach cancer live longer. Researchers want to see if this extra step, added to standard surgery and chemotherapy, can better prevent the cancer from com…

This study is testing a new drug called AZD0901 for people with advanced stomach or gastroesophageal cancer that has spread and stopped responding to initial treatments. It compares AZD0901 to the doctor's choice of standard therapies to see which works better at controlling the …

This study is testing whether a new combination of airway devices can prevent dangerous drops in blood oxygen levels in morbidly obese patients during sedated gastrointestinal endoscopy. Researchers will compare the new approach, which uses a special airway tube plus high-flow ox…

This trial is testing if a drug called capmatinib, already used for some lung cancers, can help adults with rare or uncommon cancers that have specific changes in a gene called MET. The goal is to see if the drug shrinks tumors or provides long-term benefit for these hard-to-trea…

This study is testing if a two-part strategy works better for advanced stomach cancer that has spread a little. One group gets strong drug therapy (immunotherapy plus chemo) followed by surgery to remove all visible tumors. The other group gets the drug therapy alone. The goal is…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This early-stage trial is testing a new targeted cancer drug called IKS014 in people with advanced HER2-positive solid tumors, including breast and stomach cancers. The main goals are to find the highest safe dose and see if the drug can shrink tumors. The study will enroll about…

This study is testing an experimental drug called M9140 in people with advanced gastric, lung, or pancreatic cancer that has stopped responding to standard treatments. The trial aims to see if M9140 can shrink tumors and is safe for patients. It will enroll about 250 adults whose…

This is an early-stage study testing the safety of a new experimental cancer treatment called IVX037. The treatment is a modified virus that is injected directly into tumors. Researchers are testing it alone and in combination with an existing immunotherapy drug in 70 people with…

This early-stage study is testing a new drug called MRG007 in people with advanced solid tumors that have spread and cannot be surgically removed. The main goals are to find a safe dose and see if the drug helps shrink tumors in patients with colorectal, gastric, pancreatic, and …

This is the first study testing the experimental drug JR8603 in people. It aims to find a safe dose and see if it helps control advanced solid tumors, particularly stomach, esophageal junction, and colorectal cancers, when standard treatments have stopped working. The study will …

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing a new combination of four drugs for people with advanced stomach or esophageal cancer that has a specific genetic feature called HER2. The goal is to see if adding the drug neratinib to standard chemotherapy and two other targeted drugs is safe and can bette…

This study is testing a new personalized cell therapy called CHM-2101 for people with advanced stomach, colon, or neuroendocrine cancers that have come back or stopped responding to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to be…

This study is testing five different combinations of chemotherapy and other drugs for people with advanced stomach or gastroesophageal cancer whose initial treatment has stopped working. Researchers will compare how well these different approaches control the cancer and manage si…

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This study is testing a new combination treatment for people with stage III stomach or gastroesophageal junction cancer. The goal is to see if giving immunotherapy (Serplulimab), an immune-boosting drug (thymalfasin), and standard chemotherapy (SOX) before surgery can shrink tumo…

This large, late-stage trial is comparing new drug combinations against the current standard treatment for advanced stomach or gastroesophageal cancer that has a specific marker (HER2-positive). It aims to see if adding newer targeted drugs to chemotherapy can better control the …

This early-stage trial is testing a new drug called SON-DP in people with advanced solid tumors that have not responded to standard treatments. The drug works by trying to reprogram cancer cells in the body, turning them back into normal tissue cells instead of killing them. The …

This study is for people with advanced stomach or gastroesophageal junction cancer that has continued to grow after their first round of chemotherapy. It aims to see if a new combination of two drugs (camrelizumab and apatinib) can help people live longer than the current standar…

This study is for people whose previous treatments failed to clear an H. pylori stomach infection. It tests whether adding a specific probiotic (Saccharomyces boulardii) to a standard 14-day antibiotic regimen makes the treatment more effective and safer. About 1,248 adults who h…

This study is testing whether combining two drugs, carilizumab and albumin paclitaxel, can help control advanced stomach cancer in patients whose first treatment has stopped working. It will include 40 adults whose cancer progressed after initial chemotherapy, with or without imm…

This is a first-in-human study to find a safe dose of a new drug called BAL0891. It will test the drug alone and in combination with other cancer therapies in 260 adults with advanced solid tumors or a type of leukemia that has returned or not responded to treatment. The main goa…

This study is testing if adding a special procedure called PIPAC to standard chemotherapy is better at controlling stomach cancer that has spread to the abdominal lining. PIPAC involves washing the abdomen directly with chemotherapy during surgery. Researchers will compare the sa…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is comparing a new two-drug immunotherapy combination (botensilimab + balstilimab) against standard chemotherapy plus immunotherapy for adults with advanced stomach or esophageal cancer that has specific genetic features. The main goal is to see if the new combination …

This study is testing if adding an immune-boosting drug (thymosin alpha 1) to a standard pre-surgery treatment works better for people with stage III cancer where the stomach meets the esophagus. The standard treatment combines immunotherapy, chemotherapy, and radiation to shrink…

This large Phase 3 study is testing whether adding new targeted drugs to standard chemotherapy works better for people with advanced stomach, esophageal, or gastroesophageal junction cancers. The trial is specifically for patients whose cancers test positive for a protein called …

This early-stage trial is testing a new experimental drug called AZD5863 for people with advanced stomach, esophageal junction, esophageal, or pancreatic cancers that have spread. The study aims to find the safest dose and see if the treatment can shrink tumors. It's for adults w…

This is the first study in people to test a new oral drug called NKT3964. It aims to see if the drug is safe and can help control advanced cancers that have spread and stopped responding to standard treatments. The study will enroll adults with specific advanced solid tumors, inc…

This study is testing several new combinations of cancer drugs for people with advanced stomach or gastroesophageal cancer that cannot be removed by surgery. The goal is to see if these combinations can shrink tumors, delay cancer growth, and are safe for patients. The trial is f…

This early-stage study is testing a new drug called AZD4360 in adults with advanced cancers of the stomach, pancreas, and related areas. The main goals are to find a safe dose and see if the drug shows any signs of helping to control the cancer. The drug is designed to target a s…

This study is testing a new cancer vaccine made from a patient's own or donated tumor cells. The cells are modified in a lab to train the patient's immune system to attack the cancer, then injected back into the patient. The goal is to see if this approach can help people with ad…

This study is testing if adding a special gut bacteria supplement called EXL01 to standard chemotherapy and immunotherapy drugs works better for controlling advanced stomach cancer. It will involve 120 adults with a specific type of advanced stomach cancer who haven't had prior t…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This study is testing if adding an experimental drug called givastomig to standard immunotherapy and chemotherapy works better for controlling advanced stomach or esophageal cancer. About 180 adults whose cancer has spread and who have not yet received treatment for their advance…

This is a first-in-human study to test the safety and find the right dose of a new drug called PF-08046054/SGN-PDL1V for people with advanced solid tumors. It will be tested alone and in combination with another cancer drug, pembrolizumab. The study is recruiting 714 participants…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This is an early safety study to find the right dose of two drugs, neratinib and fam-trastuzumab deruxtecan, when given together. It's for adults with advanced stomach, esophageal, or other gastrointestinal cancers that have a specific marker called HER2 and have worsened after a…

This study is testing whether two oral drugs, avutometinib and defactinib, can help people with a specific, hard-to-treat type of advanced stomach cancer live longer without their cancer getting worse. The trial is for adults whose cancer has spread or cannot be removed by surger…

This study is testing an experimental drug called AZD0901, both by itself and combined with standard chemotherapy, for people with advanced cancers of the stomach, pancreas, and bile ducts. The main goals are to see if the treatment is safe and if it can shrink tumors. It is for …

This study is testing a new drug called GAIA-102 for people with advanced stomach or pancreatic cancer that has spread to the lining of the abdomen, causing fluid buildup. The drug is injected directly into the abdomen, either alone or combined with an existing immunotherapy drug…

This trial is testing a new type of gene therapy for people with advanced pancreatic, colon, and other cancers that have a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer c…

This study is testing a new medical device designed to help obese patients breathe better and maintain safe oxygen levels while they are sedated for stomach and colon exams. The device combines several functions like oxygen support and airway management into one tool. Researchers…

This is the first-ever study in humans of a new experimental drug called TH9619 for people with advanced solid tumors. The trial aims to find a safe and effective dose while checking how the body processes the drug and whether it shows signs of fighting cancer. It's open to adult…

This study is testing whether a nutritional supplement called glutamine can help patients maintain muscle mass and strength after stomach removal surgery for cancer. Researchers will compare glutamine to a placebo in 120 patients, measuring muscle changes on CT scans and tracking…

This study is testing a smartphone-based recovery program for people with stomach cancer who are getting chemotherapy before surgery. The program includes exercises and nutrition advice. Researchers want to see if using a special app helps patients stick to the plan better than s…

This is the first study in people for a new radioactive drug called [225Ac]-FPI-2068. It aims to find a safe dose and see how the drug travels in the body of 70 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check safety…

This study is testing whether adding naturopathic doctor-guided care—including personalized diet, supplements, and lifestyle advice—to standard cancer surgery helps patients recover better. It aims to reduce complications, improve quality of life, and potentially help patients li…

This is a first-in-human study to test the safety and find the right dose of a new drug called TJ033721 (givastomig) for people with advanced or metastatic solid tumors. It will enroll about 330 patients whose cancer has progressed despite standard treatments or who have no other…

This study is testing whether a targeted cancer drug called T-DXd works better alone or when combined with chemotherapy and/or immunotherapy for advanced stomach and esophageal cancers that have a specific marker called HER2. It will involve about 450 adults with advanced cancer …

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study testing a new oral drug called MOMA-341 for people with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The main goal is to find safe doses and see how the body handles the drug when taken alone or combined with other cance…

This large Phase 3 study is testing whether adding a new antibody drug called HLX22 to standard treatment helps people with advanced HER2-positive stomach or gastroesophageal cancer live longer without their cancer getting worse. About 550 adults with previously untreated, advanc…

This study is testing an experimental drug called AZD0901 for people with advanced stomach or gastroesophageal junction cancer that has spread and expresses a specific protein called CLDN18.2. It is for adults whose cancer has continued to grow after at least one prior treatment.…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is testing three different treatment approaches for people with advanced cancers of the esophagus, stomach, colon, and other digestive organs. Researchers want to see if new drug combinations can shrink tumors and control the disease better than current options. The tr…

This trial is testing whether adding a drug called lenvatinib to standard immunotherapy and chemotherapy can help people with advanced stomach cancer that has spread to the lining of the abdomen and caused significant fluid buildup. The study aims to find a safe dose and see if t…

This early-stage trial is testing a new drug called CA-4948 in combination with standard chemotherapy and immunotherapy for people with advanced stomach or esophageal cancer that cannot be surgically removed. The study aims to find the safest dose of this combination and see if i…

This trial is testing whether combining two drugs, cabozantinib and durvalumab, is safe and effective for people with advanced cancers of the digestive system. It is for adults whose stomach, esophageal, liver, or colorectal cancer has progressed after standard treatments. The go…

This study is testing a procedure called HIPEC, where heated chemotherapy is washed directly into the abdomen during surgery, for people with stomach cancer that has spread to the abdominal lining. The main goal is to see if this treatment makes the cancer cells more visible to t…

This study is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful dose of radiation directly to cancer cells. Th…

This study tests whether a combination of three drugs can shrink advanced stomach tumors that are currently inoperable, with the goal of making surgery possible. It is for patients whose cancer has a specific protein marker (HER2 1+/2+). The main measure of success is whether the…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This study is testing a new imaging system designed to help surgeons better see cancer cells during operations for gastrointestinal cancers. Patients scheduled for surgery for colorectal, pancreatic, or esophageal cancer receive an intravenous imaging agent before their procedure…

This study is developing a blood test to find tiny, hidden traces of stomach cancer that might remain after surgery. The test looks for special genetic signals released by cancer cells. If successful, it could help doctors predict which patients are at high risk of the cancer ret…

This study is a survey to understand what people value most in a test for stomach or esophageal cancer. Researchers want to know which test features patients and the general public prefer, and if these preferences differ by location. Participants will complete a 20-25 minute onli…

This study is testing whether a special fluorescent dye called CYTALUX can help surgeons see gastrointestinal cancer cells more clearly during surgery. The dye is injected before the operation and glows under special near-infrared light, potentially revealing cancer that might ot…

This study is testing a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect five specific cancers: colorectal, ovarian, gastric, breast, and pancreatic. Researchers will check if the tracer is safe, measure its radiation dose, and see how accura…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing whether chemical markers found in a person's breath and blood can be used to detect early-stage stomach and esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with a pre-cancerous condition called Barret…

This study is testing a new fluorescent imaging probe designed to help surgeons see if early stomach cancer has spread to nearby lymph nodes during surgery. The goal is to accurately tell the difference between healthy and cancerous lymph nodes so that only the affected ones are …

This study is testing a simple, swallowable sponge capsule called EsophaCap to collect cell samples from the esophagus and stomach. Researchers aim to find biological markers that can identify early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. The goal is …

This study is testing a new type of PET scan designed to find cancers in the stomach, pancreas, bile ducts, and esophagus. It uses a special tracer that attaches to a protein called CLDN18.2, which is often found on these cancer cells. The goal is to see if this scan can accurate…

This study aims to prevent stomach cancer in Indigenous communities in Taiwan, where rates are much higher than in non-Indigenous populations. Researchers will enroll 50,000 adults aged 20-60 to test if treating a common stomach bacteria called H. pylori can lower cancer risk. Th…

This study aims to discover new biological markers that could help detect gastrointestinal cancers earlier. Researchers are collecting tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy, endoscopy, or surgery. The goal is to identify substances that …

This study aims to find specific substances in the blood that might indicate a person is at higher risk for developing stomach cancer or pre-cancerous stomach changes. Researchers will monitor these 'biomarkers' in about 192 adults who are already getting checked for stomach issu…

This study aims to understand why some stomach cancers develop specific DNA changes and how these changes affect the disease. Researchers will analyze tissue samples from 245 people who had stomach cancer surgery to look for patterns between these DNA changes, patient characteris…

This study aims to understand how specific changes in the CTNNA1 gene affect cancer risk in families. Researchers will collect family health histories from people who carry these gene changes and their close relatives. The goal is to better define cancer risks for gastric cancer,…

This study aims to learn if finding cancer cells or cancer DNA in a person's blood, urine, or bone marrow can help doctors better understand how cancer spreads. Researchers will collect samples from 100 people with cancer and 200 people at high risk for lung cancer to see if thes…

This study aims to better understand cancer cachexia—a condition where patients lose muscle and weight, which can worsen outcomes even for those undergoing potentially curative surgery. Researchers will track 200 UK patients with certain digestive cancers, along with a small comp…

This study aims to understand why some stomach changes turn into cancer while others don't. Researchers will follow 3,200 people with various stomach conditions, healthy individuals, and cancer patients to compare their characteristics over time. The goal is to identify risk fact…

This study is creating a large registry to learn more about what causes stomach cancer. It will collect health information and samples from 500 people who have had stomach cancer, have a family history of it, or carry a specific genetic risk. The goal is to find patterns that cou…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to better understand how certain stomach changes can lead to cancer. Researchers will follow 600 people who have these changes or are at high risk, collecting samples during routine check-ups. The goal is to learn who is most likely to progress to cancer, which co…

This study aims to understand if the molecular markers used to guide treatment in stomach and esophageal cancers change when the cancer spreads to the brain. Researchers will analyze stored tissue samples from 30 patients to compare the original tumor with its brain metastasis. T…

This study aims to understand stomach cancer in Algeria by collecting information from 1,000 patients. Researchers will look at patient backgrounds, how the cancer was found, what treatments were used, and how patients responded. The goal is to create a detailed picture of stomac…

This study aims to find out if simple blood tests can predict how well patients with advanced cancers respond to immunotherapy drugs. Researchers will track 50 patients with late-stage lung, breast, colorectal, liver, or stomach cancer who are starting immunotherapy. They will co…

This study looks back at the medical records of 1,200 patients who had surgery for various cancers. Researchers want to understand how often and why some patients develop voice problems or throat injuries after having a breathing tube placed during anesthesia. By identifying the …

This study aims to follow people with gastrointestinal stromal tumors (GIST) to collect their tumor tissue for laboratory research. Participants will be monitored for up to 10 years and may have surgery at the NIH if needed. The main goal is to use the collected tissue to create …

This study aims to see if the types of bacteria in a patient's gut can help predict how well their stomach cancer will respond to a combination of immunotherapy and chemotherapy. It will enroll 300 adults with advanced stomach cancer who have not had prior chemotherapy or immunot…