GASTRIC CANCER

This study compares two types of minimally invasive surgery for early-stage stomach cancer: reduced-port robotic surgery and conventional laparoscopic surgery. About 538 adults aged 20 to 80 with early gastric cancer will be randomly assigned to one of the two procedures. The mai…

This phase 3 trial tests whether adding TST001 (a drug targeting a protein found on stomach cancer cells) to standard chemotherapy and immunotherapy can help people with advanced stomach or gastroesophageal junction cancer live longer without their disease getting worse. About 82…

This study tests whether adding the drug ivonescimab to standard chemotherapy (SOX) works better than chemo alone for people with locally advanced stomach or gastroesophageal junction cancer. About 154 adults will receive treatment every 3 weeks for 4 months before surgery. The m…

This study tests a new drug, BHB810, in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety, find the best dose, and see if it can s…

This study tests a new drug called BL-M05D1 in people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2) and has stopped responding to initial treatment. About 438 adults will be randomly assigned to receive either BL-M05D1 or a standa…

This study tests whether adding the immunotherapy drug adebrelimab, with or without the targeted drug apatinib, to standard chemotherapy (SOX) can shrink advanced stomach cancer before surgery. About 118 adults with HER2-negative stomach cancer that cannot be removed right away w…

This study tests whether adding a short course of radiation to standard chemotherapy before surgery can improve outcomes for people with early-stage stomach cancer. About 20 adults will receive this combination, then have surgery or monitoring. The goal is to see if this approach…

This study tests whether a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) plus chemotherapy can help people with advanced stomach or gastroesophageal junction cancer whose first treatment stopped working. About 30 adults aged 18-75 will receive the drug com…

This study looks at whether adding beta-blockers (a type of blood pressure medicine) to standard immunotherapy before surgery can help shrink tumors in people with locally advanced stomach cancer who also have high blood pressure. About 33 participants will receive the combinatio…

This study aims to see if combining a special PET scan (18F-FAPI) with detailed MRI can better diagnose and predict outcomes for people with gastric cancer. Researchers will enroll 230 patients suspected or diagnosed with gastric cancer. The goal is to improve how doctors detect …

This study will test a new type of PET scan that looks for a protein called Claudin18.2 in people with pancreatic, stomach, or gastroesophageal junction cancer. The goal is to see how well the scan can find this protein, which may help doctors choose the right targeted therapy. A…

This study tests a new fluorescent probe that makes stomach cancer cells glow, helping surgeons see exactly where the tumor ends during surgery. The probe is based on a safe human protein and will be tested on 32 stomach tissue samples in the lab. The goal is to improve accuracy …

This study tests two methods to reduce pain after keyhole stomach cancer surgery. One group gets a standard ultrasound-guided nerve block, while the other gets a special gel applied directly to the surgical site. The goal is to see which approach provides better pain relief and h…

This study looks at whether a drug called remimazolam can lower the chance of confusion (delirium) after stomach cancer surgery in people aged 65 and older. About 170 participants will get either remimazolam or standard anesthesia. The goal is to see if remimazolam leads to clear…

This study tests whether a simple blood test that looks for tumor DNA (ctDNA) can help doctors decide on the best treatment after surgery for stomach or gastroesophageal junction cancer. About 32 people with stage III or IVA cancer will have their blood checked at several times b…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how doct…

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery for breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had their cancer removed will give blood samples over a year. The goal is to learn how often this DNA is found…