GASTRIC CANCER

This early-stage trial is testing whether a new experimental drug called RO7496353 is safe and effective when combined with existing immunotherapy and chemotherapy. The study involves 102 people with advanced lung, stomach, or pancreatic cancers that have spread and are considere…

This study is testing whether adding an experimental drug called Q702 to an existing immunotherapy (pembrolizumab) can help control advanced cancers that have stopped responding to previous treatments. The trial will enroll 120 people with advanced esophageal, stomach, liver, or …

This early-stage trial is testing a new drug called INBRX-106, both by itself and combined with an existing immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how …

This is the first human study testing the safety and early effects of an experimental drug called BL-M17D1 in people with advanced cancers that have a specific marker called HER2. The trial will enroll 120 adults with various hard-to-treat cancers, including breast, lung, and sto…

This early-stage study is testing whether a diet low in the amino acid leucine is safe for people with stomach cancer who are scheduled for surgery. Researchers will check for side effects and measure changes in blood amino acid levels and immune cells. The goal is to see if this…

This is the first human study testing the safety of an experimental drug called AB598 in people with advanced cancers. The trial will enroll 40 participants with various cancers including lung, stomach, bladder, and breast cancer to determine safe dosage levels and monitor side e…

This study is testing a new drug called bemarituzumab, given in combination with other cancer therapies, for people with previously untreated advanced stomach or gastroesophageal junction cancer. The main goals are to see if the combinations are safe and if they can shrink tumors…

This study is testing two different combinations of newer cancer drugs with standard treatments for people with advanced stomach cancer that has spread. It aims to see if these combinations are safe and effective for patients with different levels of a protein called HER2. The tr…

This large study is testing whether a shorter, 4-month course of chemotherapy is just as effective as the standard 6-month course for patients who have had surgery for stage II or III stomach cancer. The goal is to see if the shorter treatment can control the cancer just as well …

This study is testing whether using a Fitbit and a mobile app can help patients recover better after major surgery for gastrointestinal cancers. About 107 patients were randomly assigned to either use the app and tracker along with their usual care, or to receive usual care alone…

This early-stage study is testing a new drug called AZD7789 in people with advanced lung or stomach cancers that have spread and stopped responding to standard immunotherapy. The main goals are to find a safe dose and see if the drug shows any signs of shrinking tumors. The drug …

This study is testing whether adding an experimental drug called ONO-4578 to standard chemotherapy and immunotherapy works better for advanced stomach cancer. It will involve about 226 patients who have not yet received chemotherapy for their cancer. The main goal is to see if th…

This study is testing whether adding a new immunotherapy drug (atezolizumab) to a standard chemotherapy and targeted therapy combination works better before surgery for people with a specific type of stomach or gastroesophageal cancer (HER2-positive). The goal is to shrink the tu…

This is the first time a new drug called TORL-2-307-ADC is being tested in people. The main goal is to find a safe dose and see how the body handles it in 163 patients with advanced solid tumors, including stomach and pancreatic cancer. Researchers will also look for early signs …

This study is testing a new combination of immune-boosting drugs for people with advanced cancers whose disease has progressed after treatment with standard immunotherapies like pembrolizumab or nivolumab. It aims to see if adding a drug called NAI to other treatments can help sh…

This early-stage study is testing a new drug called MCLA-129, which is designed to attack cancer cells by blocking two different growth signals at once. It is for adults with advanced lung, stomach, head/neck, or other solid tumors that have stopped responding to standard treatme…

This is an early-stage study testing the safety and optimal dose of a new treatment called LB1908, a type of CAR-T cell therapy, for adults with advanced cancers of the stomach, esophagus, or pancreas. The therapy involves collecting a patient's own immune cells, engineering them…

This study is testing whether adding a new targeted drug called bemarituzumab to standard chemotherapy helps people with advanced stomach or gastroesophageal cancer live longer. It is for adults with a specific biomarker (FGFR2b) in their tumor who have not yet received treatment…

This is an early-stage study to find a safe dose of a new immunotherapy drug called HFB200301. It is being tested alone and in combination with an existing drug (tislelizumab) in adults with advanced solid tumors who have already tried other treatments. The main goal is to see ho…

This study is testing a combination of three drugs to see if they can shrink advanced stomach tumors enough for surgeons to remove them completely. It is for adults with stage IV gastric cancer that cannot be operated on initially. The goal is to control the disease by converting…

This early-stage trial is testing four different combinations of experimental drugs with existing cancer medications for people with metastatic solid tumors. The study aims to find safe doses and see if these combinations can shrink tumors in seven specific cancer types. It's des…

This early-stage study is testing a new drug called RNDO-564, both by itself and combined with an existing immunotherapy (pembrolizumab), in adults with advanced cancers that have stopped responding to standard treatments. The main goals are to find safe doses and see how the bod…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced colorectal and other gastrointestinal cancers that have stopped responding to standard treatments. The trial combines an oral pill (vorbipiprant) with an immunotherapy drug (…

This is an early-stage study to find a safe dose of a new immunotherapy drug called HFB200603. It will be tested alone and in combination with an existing drug, tislelizumab, in 83 adults with advanced solid tumors like lung, kidney, or skin cancer. The main goal is to check for …

This study is testing an experimental drug called zolbetuximab for people with advanced stomach or gastroesophageal junction cancer. The drug targets a specific protein (CLDN18.2) found on many of these tumors, aiming to flag them for the body's own immune system to attack. Resea…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This is a first-in-human study testing a new type of cancer treatment called P-MUC1C-ALLO1 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body tolerates this 'off-the-shelf' CAR-T …

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This study is testing a new drug called ASKB589, given alongside standard chemotherapy and immunotherapy, for people with advanced stomach or gastroesophageal junction cancer. The main goals are to find a safe dose and see how well the body handles the drug combination. Researche…

This study is testing whether adding a new targeted drug called bemarituzumab to standard chemotherapy and immunotherapy helps people with advanced stomach or gastroesophageal cancer live longer. It's for adults with a specific tumor marker (FGFR2b) who haven't had treatment for …

This trial is testing a two-step treatment for stomach or gastroesophageal cancer that has spread to the abdominal lining. First, patients receive standard chemotherapy. If the cancer hasn't spread to other organs, they then receive a second type of chemotherapy delivered directl…

This early-stage trial is testing a new drug called TST001 for people with advanced stomach, gastroesophageal junction, or pancreatic cancer. The main goals are to find a safe dose and see how well the body handles the drug, both alone and when combined with other standard cancer…

This study aims to prevent stomach cancer and ulcers by screening people for H. pylori, a common stomach infection, and treating those who test positive. It focuses on 75 people in South Florida who already tested positive and completed treatment. The main goal is to compare whet…

This large study is testing personalized screening strategies to prevent stomach and colorectal cancers. It will enroll 40,000 healthy adults aged 50-75 to see if combining specific tests can better identify people at highest risk. The goal is to guide more effective screening an…

This study aims to see if finding and treating a common stomach infection (H. pylori) can prevent serious stomach problems, including cancer. Researchers are screening 500 adults in South Florida with a simple breath test. Those who test positive will be offered free treatment wi…

This study is testing a new surgical technique for patients who need their entire stomach removed due to cancer. The method creates a small pouch from intestine to help reduce common side effects like rapid food dumping and poor nutrition. Researchers want to see if this approach…

This study aims to find the better surgery to relieve a blockage caused by advanced stomach cancer. It compares two palliative (symptom-relieving) procedures: removing the tumor versus creating a bypass around it. The main goal is to see which surgery more effectively relieves th…

This study looks back at the medical records of 230 patients to understand how different treatments for brain metastases from stomach or esophageal cancer affect survival. Researchers are comparing surgery, radiation, and combinations of these treatments. The goal is to find whic…

This study collects leftover tissue and blood samples from patients with various cancers to help researchers understand these diseases better. The samples come from patients already having medical procedures, using only material that would otherwise be discarded. Researchers will…