GASTRIC CANCER

This was a first-in-human study to find a safe dose of a new experimental cancer drug called SNB-101. The drug, a nanoparticle form of an existing chemotherapy, was given by IV to 21 patients with advanced solid tumors that had stopped responding to standard treatments. The main …

This early-stage study tested whether adding a new investigational therapy called VE800—a preparation of specific bacteria—could improve the effectiveness of an existing immunotherapy drug (nivolumab) in patients with advanced or metastatic cancers. The trial enrolled 56 patients…

This study tested whether a drug called crizotinib, used for some lung cancers, could help control advanced lobular breast cancer and certain other hard-to-treat cancers. For breast cancer patients, it was combined with a hormone-blocking drug called fulvestrant. The main goal wa…

This first-in-human study tested a new drug called Cabotamig in 33 adults with advanced gastrointestinal cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, see how the body processes it, and look for early signs that it mig…

This large, completed study tested if adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with stomach or gastroesophageal cancer. The goal was to see if the combination, given both before and after surgery, helps keep the cancer from returning and i…

This study tested if a specific type of stomach reconstruction surgery, performed on patients with both early-stage gastric cancer and type 2 diabetes, could improve their blood sugar control. Researchers compared a new, longer bypass technique to the standard method to see which…

This study tested whether combining two drugs, TAS-102 and ramucirumab, is safe and can help people with advanced stomach or gastroesophageal cancer that has stopped responding to other treatments. It involved 23 patients to see if the combination could help them live longer and …

This early-stage study tested a new immunotherapy drug called CUE-102 in patients with advanced cancers that had returned or spread after standard treatments. The main goals were to find a safe dose and see how the body processes the drug. It involved 42 adults with specific type…

This study tested whether adding a new immunotherapy drug (SAR444245) to other standard cancer drugs could help control advanced cancers of the digestive system, including stomach, liver, and colon cancers. It involved 138 adults whose cancer had spread and was no longer respondi…

This study tested whether adding an experimental drug called FLX475 to an existing immunotherapy (pembrolizumab) could help control advanced stomach cancer. It enrolled about 90 patients whose cancer had progressed despite previous treatments, including separate groups based on t…

This study tested whether combining two chemotherapy drugs with two targeted antibody drugs was safe and effective for people with advanced HER2-positive stomach or esophageal cancer. It involved 37 adults whose cancer had spread and who had not received these specific drugs befo…

This study tested a new method for adjusting chemotherapy doses to prevent unplanned treatment delays. It involved 52 adults with cancers of the digestive system (like colorectal or stomach cancer) who were receiving a common chemotherapy regimen called FOLFOX. The goal was to se…

This early-stage study tested a new type of cell therapy for people with advanced stomach or pancreatic cancer that has stopped responding to standard treatments. Doctors gave 10 patients immune cells from donated cord blood that were engineered to attack a specific protein found…

This study tested whether a new drug called GEN-001, when combined with an existing immunotherapy (avelumab), could help control advanced stomach or gastroesophageal junction cancer. It was for patients whose cancer had progressed after at least two prior standard treatments and …

This study aimed to find the best length of immunotherapy treatment for people with advanced cancers. It enrolled 161 patients whose cancer had remained stable after one year of treatment. Researchers randomly assigned participants to either stop their immunotherapy or continue i…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with stomach or gastroesophageal junction cancer. It involved 120 Chinese adults who hadn't received prior treatment, giving the drug combination both before and after surg…

This large study tested whether adding two newer drugs (camrelizumab and apatinib) to standard chemotherapy works better than chemotherapy alone for advanced stomach cancer. The trial involved 885 patients who hadn't received previous treatment for their advanced cancer. Research…

This early-phase trial tested a new personalized therapy for advanced gastrointestinal and other cancers driven by a specific genetic flaw called RAS G12D. Researchers collected a patient's own immune cells, genetically modified them in a lab to recognize and attack cancer cells …

This early-stage study tested a new drug called SHR-A1811 in 101 patients with advanced stomach or colorectal cancer that had stopped responding to standard treatments. The main goals were to find a safe dose and check for early signs that the drug might help control these cancer…

This study tested whether combining two drugs, telatinib and Keytruda, could help control advanced stomach or liver cancers that had worsened after standard treatments. It involved 16 patients with these specific cancers. The main goal was to see how long the combination could ke…

This study tested whether a new, targeted chemotherapy method could help control stomach cancer that has spread to the abdominal lining. Doctors combined standard chemotherapy with a newer technique called PIPAC, which sprays chemotherapy as a mist directly into the abdomen. The …

This study compared two ways to perform surgery for removable stomach cancer: traditional open surgery and newer laparoscopic (keyhole) surgery. It involved 210 patients in Western countries to see if the keyhole method leads to a shorter hospital stay and fewer complications aft…

This study tested the safety and effectiveness of combining two drugs, pembrolizumab and lenvatinib, in people with advanced solid tumors that had stopped responding to standard treatments. It involved 611 participants with cancers like triple-negative breast, ovarian, gastric, c…

This study tested a training program for doctors to use a special microscope called confocal laser endomicroscopy (CLE) during endoscopy. The goal was to see if the training helped doctors more accurately spot stomach cancer and precancerous growths in real-time. The study involv…

This study tested a new type of PET scan designed to better detect and locate gastrointestinal cancers. The scan uses a special tracer that attaches to a protein often found in these tumors. Researchers compared the scan results to tissue samples from 109 patients to see how accu…

This study tested a new scoring model designed to predict whether a patient's stomach cancer has spread to their lymph nodes before they have surgery. Doctors followed 120 patients who had surgery for stomach cancer to see if the model's predictions matched what was found during …

This study tested a new type of PET scan (called FAPI PET/CT) to see if it is more accurate than the standard FDG PET scan for finding stomach and gastro-esophageal junction cancer. It involved 20 patients who got both types of scans when first diagnosed and again after chemother…

This study aimed to prevent gastric (stomach) cancer in Bhutan by finding and treating people infected with H. pylori, a common stomach bacteria that raises cancer risk. Over 1,000 permanent residents aged 12 and up from 24 villages were tested. Those found to be infected were of…

This study tested a tool designed to predict which stomach cancer patients are at higher risk of the cancer spreading to their liver after surgery. Researchers followed 120 patients who had their stomach tumor removed to see if the tool's predictions matched what actually happene…

This study tested a new automated system to see if it could grow cancer cells from patients with advanced metastatic cancer inside chicken eggs. The goal was to create a faster, cheaper research model to help scientists study cancer and test potential drugs. The study involved 10…

This study followed over 30,000 people in China for years after they took part in trials testing vitamin and mineral supplements to prevent stomach and esophageal cancer. The goal was to see if the health benefits from the supplements lasted after people stopped taking them and t…

This study looked back at medical records to understand how well the drug nivolumab worked in real-world practice for 260 patients in China with advanced stomach cancer. It did not test a new treatment but collected information on how long the cancer was controlled and how patien…