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Can a vaccine stop stomach cancer from coming back?

NCT ID NCT05771584

Ongoing ⭐️ CURE ⭐️ Sponsor: Aston Sci. Inc. Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether a therapeutic cancer vaccine called AST-301 can safely train the immune system to fight HER2-expressing gastric cancer cells. The study enrolls people with stage II or III gastric cancer who have already had surgery and completed standard adjuvant treatment. Participants receive the vaccine plus an immune booster in either 3 or 6 doses, and researchers will monitor for side effects and immune responses, as well as how long participants remain cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a therapeutic cancer vaccine called AST-301 (pNGVL3-hICD) plus an immune booster (sargramostim)
What this could lead to
If successful, this vaccine could train the immune system to recognize and destroy leftover cancer cells, potentially preventing gastric cancer from coming back after surgery and standard therapy.
What could go wrong
This is an early proof-of-concept trial with only 24 participants, so results may not apply broadly. The vaccine may cause side effects or fail to trigger a strong enough immune response to prevent recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER

Contacts and locations

Locations

  • Chang Gung Memorial Hospital Linkou

    Taoyuan, 333, Taiwan

  • Chi Mei Medical Center

    Tainan, 710, Taiwan

  • China Medical University Hospital

    Taichung, 404, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

More trials for these conditions

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