Radioactive 'Smart Bomb' targets Hard-to-Treat cancers in first human test
NCT ID NCT06147037
First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times
Summary
This early-stage trial is testing a new drug that delivers a tiny amount of radiation directly to cancer cells. It is for people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to standard treatments. The study will check if the drug is safe, how it spreads in the body, and what dose might work best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a radioactive drug (actinium-225 attached to a targeting antibody) that delivers radiation directly to cancer cells
- What this could lead to
- If it works, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to other therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 70 participants, so safety and the right dose are still being figured out. The radioactive drug may cause side effects and may not shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
Palo Alto, California, 94304, United States
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Research Site
Chicago, Illinois, 60637, United States
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Research Site
Omaha, Nebraska, 68130, United States
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Research Site
Cleveland, Ohio, 44195, United States
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Research Site
Houston, Texas, 77030, United States
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Research Site
Seattle, Washington, 98109, United States
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Research Site
Montreal, Quebec, H2X 0A9, Canada
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Research Site
Sherbrooke, Quebec, J1H 5N4, Canada
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