New targeted drug shows promise in stomach cancer trial

NCT ID NCT06346392

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests a new drug called AZD0901 against standard chemotherapy in 592 adults with advanced stomach or gastroesophageal junction cancer that has not responded to prior treatments. The drug targets a protein called CLDN18.2 found on some cancer cells. The study measures how long patients live without their cancer worsening and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD0901 (also called Sonesitatug Vedotin)

What this could lead to

If successful, this could provide a new treatment option for people with advanced gastric cancer that has not responded to prior therapies.

What could go wrong

This is a Phase 3 trial, but results are not yet available. The drug may not improve survival or could have side effects. It is only for patients with a specific protein (CLDN18.2) on their tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER GASTROESOPHAGEAL JUNCTION CANCER

Contacts and locations

Show contact details

Locations

Research Site

Mobile, Alabama, 36604, United States
Research Site

Tucson, Arizona, 85719, United States
Research Site

Duarte, California, 91010, United States
Research Site

Irvine, California, 92618, United States
Research Site

Los Angeles, California, 90048, United States
Research Site

Los Angeles, California, 90089, United States
Research Site

Newport Beach, California, 92663, United States
Research Site

Washington D.C., District of Columbia, 20007, United States
Research Site

Hollywood, Florida, 33021, United States
Research Site

Orlando, Florida, 32804, United States
Research Site

Marietta, Georgia, 30060, United States
Research Site

Boise, Idaho, 83712, United States
Research Site

Lexington, Kentucky, 40536, United States
Research Site

Boston, Massachusetts, 02114, United States
Research Site

Ann Arbor, Michigan, 48106, United States
Research Site

Ann Arbor, Michigan, 48109, United States
Research Site

Kansas City, Missouri, 64111, United States
Research Site

Mineola, New York, 11501, United States
Research Site

New York, New York, 10016, United States
Research Site

New York, New York, 10032, United States
Research Site

New York, New York, 10065, United States
Research Site

Philadelphia, Pennsylvania, 19111, United States
Research Site

York, Pennsylvania, 17403, United States
Research Site

Charlottesville, Virginia, 22908, United States
Research Site

Fredericksburg, Virginia, 22408, United States
Research Site

Olympia, Washington, 98502, United States
Research Site

Ribeirão Preto, 14051-140, Brazil
Research Site

São Paulo, 05652-900, Brazil
Research Site

Vitória, 29043-272, Brazil
Research Site

Barrie, Ontario, L4M 6M2, Canada
Research Site

London, Ontario, N6C 2R5, Canada
Research Site

North York, Ontario, M2K 1E1, Canada
Research Site

Ottawa, Ontario, K1H 8L6, Canada
Research Site

Toronto, Ontario, M5G 2M9, Canada
Research Site

Montreal, Quebec, H3G 1A4, Canada
Research Site

Beijing, 100210, China
Research Site

Changchun, 130021, China
Research Site

Chengdu, 610000, China
Research Site

Chengdu, 610042, China
Research Site

Fuzhou, 350001, China
Research Site

Fuzhou, 350014, China
Research Site

Guangzhou, 510060, China
Research Site

Guangzhou, 510120, China
Research Site

Guangzhou, 510655, China
Research Site

Guangzhou, 510700, China
Research Site

Hangzhou, 310020, China
Research Site

Hangzhou, 310022, China
Research Site

Harbin, 150049, China
Research Site

Hefei, 230022, China
Research Site

Hefei, 230031, China
Research Site

Hefei, 230601, China
Research Site

Jinan, 250117, China
Research Site

Jining, 272029, China
Research Site

Lanzhou, 730000, China
Research Site

Lishui, 323000, China
Research Site

Nanjing, 210008, China
Research Site

Qingdao, 266034, China
Research Site

Shanghai, 200025, China
Research Site

Shanghai, 200032, China
Research Site

Shanghai, 200040, China
Research Site

Shenyang, 110042, China
Research Site

Shijiazhuang, 050011, China
Research Site

Suzhou, 215004, China
Research Site

Tianjin, 300060, China
Research Site

Ürümqi, 830000, China
Research Site

Wuhan, 430000, China
Research Site

Wuhan, 430030, China
Research Site

Xi'an, 710061, China
Research Site

Yinchuan, 750004, China
Research Site

Zhengzhou, 450003, China
Research Site

Besançon, 25030, France
Research Site

Brest, 29200, France
Research Site

Lille, 59037, France
Research Site

Lyon, 69008, France
Research Site

Nantes, 44000, France
Research Site

Berlin, 10249, Germany
Research Site

Berlin, 13353, Germany
Research Site

Frankfurt, 60488, Germany
Research Site

Göttingen, 37075, Germany
Research Site

Hamburg, 20246, Germany
Research Site

Heidelberg, 69120, Germany
Research Site

Heilbronn, 74078, Germany
Research Site

Leipzig, 04103, Germany
Research Site

Marburg, 35043, Germany
Research Site

Moers, 47441, Germany
Research Site

München, 81377, Germany
Research Site

Hong Kong, 150001, Hong Kong
Research Site

Hong Kong, Hong Kong
Research Site

Ahmedabad, 380015, India
Research Site

Hyderabad, 500032, India
Research Site

Mumbai, 400012, India
Research Site

New Delhi, 110085, India
Research Site

Florence, 50134, Italy
Research Site

Milan, 20133, Italy
Research Site

Milan, 20162, Italy
Research Site

Naples, 80131, Italy
Research Site

Padova, 35128, Italy
Research Site

Pisa, 56100, Italy
Research Site

Vicenza, 36100, Italy
Research Site

Fukuoka, 812-8582, Japan
Research Site

Kashiwa, 227-8577, Japan
Research Site

Kōtoku, 135-8550, Japan
Research Site

Nagoya, 464-8681, Japan
Research Site

Ogaki-shi, 503-8502, Japan
Research Site

Osaka, 541-8567, Japan
Research Site

Sunto-gun, 411-8777, Japan
Research Site

Tokyo, 104-0045, Japan
Research Site

Toyoake-shi, 470-1192, Japan
Research Site

Yokohama, 241-8515, Japan
Research Site

Bielsko-Biala, 43-300, Poland
Research Site

Gdansk, 80-219, Poland
Research Site

Katowice, 40-514, Poland
Research Site

Krakow, 31-501, Poland
Research Site

Lublin, 20-080, Poland
Research Site

Słupsk, 76-200, Poland
Research Site

Warsaw, 02-034, Poland
Research Site

Warsaw, 04-141, Poland
Research Site

Gyeonggi-do, 13620, South Korea
Research Site

Seoul, 03080, South Korea
Research Site

Seoul, 03722, South Korea
Research Site

Seoul, 05505, South Korea
Research Site

Seoul, 06351, South Korea
Research Site

Seoul, 06591, South Korea
Research Site

Barcelona, 08036, Spain
Research Site

Barcelona, 8035, Spain
Research Site

Madrid, 28034, Spain
Research Site

Madrid, 28041, Spain
Research Site

Ourense, 32005, Spain
Research Site

Santander, 39008, Spain
Research Site

Seville, 41013, Spain
Research Site

Bern, 3010, Switzerland
Research Site

Geneva, 1205, Switzerland
Research Site

Lausanne, 1011, Switzerland
Research Site

Zurich, 8032, Switzerland
Research Site

Kaohsiung City, 00807, Taiwan
Research Site

Kaohsiung City, 83301, Taiwan
Research Site

Taichung, 40447, Taiwan
Research Site

Tainan, 704, Taiwan
Research Site

Taipei, 10002, Taiwan
Research Site

Taipei, 112, Taiwan
Research Site

Taoyuan, 333, Taiwan
Research Site

Bangkok, 10700, Thailand
Research Site

Dusit, 10300, Thailand
Research Site

Hat Yai, 90110, Thailand
Research Site

Khon Kaen, 40002, Thailand
Research Site

Ankara, 06230, Turkey (Türkiye)
Research Site

Diyarbakır, 21280, Turkey (Türkiye)
Research Site

Erzurum, 25240, Turkey (Türkiye)
Research Site

Istanbul, 34098, Turkey (Türkiye)
Research Site

Cambridge, CB2 0QQ, United Kingdom
Research Site

London, EC1A 7BE, United Kingdom
Research Site

London, SW3 6JJ, United Kingdom
Research Site

Manchester, M20 4BX, United Kingdom
Research Site

Oxford, OX3 7LE, United Kingdom
Research Site

Taunton, TA1 5DA, United Kingdom
Research Site

Hanoi, 100000, Vietnam
Research Site

Ho Chi Minh City, 700000, Vietnam
Research Site

Vinh, 460000, Vietnam