New targeted drug shows promise in stomach cancer trial

NCT ID NCT06346392

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This Phase 3 trial tests a new drug called AZD0901 against standard chemotherapy in 592 adults with advanced stomach or gastroesophageal junction cancer that has not responded to prior treatments. The drug targets a protein called CLDN18.2 found on some cancer cells. The study measures how long patients live without their cancer worsening and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD0901 (also called Sonesitatug Vedotin)
What this could lead to: If successful, this could provide a new treatment option for people with advanced gastric cancer that has not responded to prior therapies.
What could go wrong: This is a Phase 3 trial, but results are not yet available. The drug may not improve survival or could have side effects. It is only for patients with a specific protein (CLDN18.2) on their tumors.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER GASTROESOPHAGEAL JUNCTION CANCER

Contacts and locations

Locations

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Mobile, Alabama, 36604, United States
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Tucson, Arizona, 85719, United States
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Duarte, California, 91010, United States
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Irvine, California, 92618, United States
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Los Angeles, California, 90048, United States
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Los Angeles, California, 90089, United States
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Newport Beach, California, 92663, United States
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Washington D.C., District of Columbia, 20007, United States
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Hollywood, Florida, 33021, United States
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Orlando, Florida, 32804, United States
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Marietta, Georgia, 30060, United States
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Boise, Idaho, 83712, United States
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Lexington, Kentucky, 40536, United States
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Boston, Massachusetts, 02114, United States
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Ann Arbor, Michigan, 48106, United States
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Ann Arbor, Michigan, 48109, United States
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Kansas City, Missouri, 64111, United States
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Mineola, New York, 11501, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Philadelphia, Pennsylvania, 19111, United States
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York, Pennsylvania, 17403, United States
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Charlottesville, Virginia, 22908, United States
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Fredericksburg, Virginia, 22408, United States
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Olympia, Washington, 98502, United States
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Ribeirão Preto, 14051-140, Brazil
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São Paulo, 05652-900, Brazil
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Vitória, 29043-272, Brazil
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Barrie, Ontario, L4M 6M2, Canada
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London, Ontario, N6C 2R5, Canada
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North York, Ontario, M2K 1E1, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3G 1A4, Canada
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Beijing, 100210, China
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Changchun, 130021, China
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Chengdu, 610000, China
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Chengdu, 610042, China
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Fuzhou, 350001, China
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Fuzhou, 350014, China
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Guangzhou, 510060, China
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Guangzhou, 510120, China
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Guangzhou, 510655, China
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Guangzhou, 510700, China
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Hangzhou, 310020, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Hefei, 230022, China
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Hefei, 230031, China
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Hefei, 230601, China
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Jinan, 250117, China
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Jining, 272029, China
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Lanzhou, 730000, China
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Lishui, 323000, China
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Nanjing, 210008, China
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Qingdao, 266034, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shanghai, 200040, China
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Shenyang, 110042, China
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Shijiazhuang, 050011, China
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Suzhou, 215004, China
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Tianjin, 300060, China
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Ürümqi, 830000, China
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Wuhan, 430000, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Yinchuan, 750004, China
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Zhengzhou, 450003, China
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Besançon, 25030, France
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Brest, 29200, France
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Lille, 59037, France
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Lyon, 69008, France
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Nantes, 44000, France
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Berlin, 10249, Germany
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Berlin, 13353, Germany
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Frankfurt, 60488, Germany
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Göttingen, 37075, Germany
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Hamburg, 20246, Germany
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Heidelberg, 69120, Germany
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Heilbronn, 74078, Germany
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Leipzig, 04103, Germany
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Marburg, 35043, Germany
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Moers, 47441, Germany
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München, 81377, Germany
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Hong Kong, 150001, Hong Kong
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Hong Kong, 999077, Hong Kong
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Ahmedabad, 380015, India
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Hyderabad, 500032, India
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Mumbai, 400012, India
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New Delhi, 110085, India
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Florence, 50134, Italy
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Milan, 20133, Italy
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Milan, 20162, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Pisa, 56100, Italy
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Vicenza, 36100, Italy
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Fukuoka, 812-8582, Japan
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Kashiwa, 227-8577, Japan
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Kōtoku, 135-8550, Japan
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Nagoya, 464-8681, Japan
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Ogaki-shi, 503-8502, Japan
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Osaka, 541-8567, Japan
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Sunto-gun, 411-8777, Japan
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Tokyo, 104-0045, Japan
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Toyoake-shi, 470-1192, Japan
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Yokohama, 241-8515, Japan
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Bielsko-Biala, 43-300, Poland
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Gdansk, 80-219, Poland
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Katowice, 40-514, Poland
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Krakow, 31-501, Poland
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Lublin, 20-080, Poland
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Słupsk, 76-200, Poland
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Warsaw, 02-034, Poland
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Warsaw, 04-141, Poland
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Ourense, 32005, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Bern, 3010, Switzerland
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Geneva, 1205, Switzerland
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Lausanne, 1011, Switzerland
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Zurich, 8032, Switzerland
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Kaohsiung City, 00807, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10700, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06230, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Oxford, OX3 7LE, United Kingdom
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Taunton, TA1 5DA, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Vinh, 460000, Vietnam

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