New drug cocktail aims to fight stomach cancer when first treatment fails

NCT ID NCT07139587

First seen Jun 26, 2026 ยท Last updated Jun 26, 2026

Summary

This clinical trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) plus chemotherapy (albumin-bound paclitaxel) as a second-line treatment for advanced stomach or gastroesophageal junction cancer. The study will enroll 30 adults whose cancer has worsened or who could not tolerate first-line treatment. The goal is to see if this combination can shrink tumors and extend survival.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Iparomlimab/Tuvonralimab (immunotherapy) combined with albumin-bound paclitaxel (chemotherapy)
What this could lead to
If successful, this could offer a new second-line treatment option for advanced stomach cancer, potentially extending life and controlling the disease.
What could go wrong
This is a very small, early-phase trial with only 30 participants. The combination may not work better than existing options and could cause significant side effects from both immunotherapy and chemotherapy.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hebei General Hospital

    Shijiazhuang, Hebei, 050000, China

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Other studies related to the condition(s) this trial covers.