New drug duo targets Hard-to-Treat cancers

NCT ID NCT06795412

Recruiting now Disease control Sponsor: Pyxis Oncology, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called PYX-201 combined with pembrolizumab in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the combination can shrink tumors. About 220 adults with certain cancers like head and neck, breast, or stomach cancer can join.

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Conditions

The condition(s) this trial relates to.

cervical cancer gastric cancer head and neck squamous cell carcinoma hormone receptor-positive breast cancer neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS ADVANCED SOLID TUMOURS

Contacts and locations

Locations

Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Hopital Saint - Andre - CHU de Bordeaux
RECRUITING

Bordeaux, 33075, France
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hôpital de la Timone
RECRUITING

Marseille, 13385, France
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
NEXT Oncology Houston
RECRUITING

Houston, Texas, 77054, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
START Madrid - Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Sarcoma Oncology Center
RECRUITING

Santa Monica, California, 90403, United States
University of California San Diego
RECRUITING

San Diego, California, 92093, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Texas - M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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