Sugar alcohol sorbitol may supercharge chemo and immunotherapy for stomach cancer
NCT ID NCT06826079
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether taking oral sorbitol, a common sugar alcohol, can enhance the effects of standard chemotherapy and an immunotherapy drug (tirellizumab) in people with locally advanced stomach cancer. Eighty participants will receive either sorbitol or a placebo alongside their cancer treatment for three months. The goal is to see if sorbitol increases the number of patients whose tumors shrink significantly before surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sorbitol
- What this could lead to
- If it works, this could point toward a simple, cheap way to make standard cancer treatments more effective for gastric cancer patients.
- What could go wrong
- This is an early phase 2/3 trial with only 80 participants. Sorbitol is a sugar alcohol, and high doses may cause digestive side effects like bloating or diarrhea. The benefit is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, 470000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- A high-tech camera may take the guesswork out of spotting a dangerous surgery complication
- Can surgery for stomach or esophageal cancer cloud the mind?
- Can an immunotherapy combo shrink stomach tumors before surgery?