Gut bacteria pill could boost stomach cancer treatment
NCT ID NCT06253611
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding a daily pill containing a specific gut bacterium (EXL01) to standard immunotherapy (nivolumab) and chemotherapy (FOLFOX) can shrink tumors better than the drugs alone in people with advanced gastric cancer. About 120 participants will be randomly assigned to receive either the combination or the standard regimen. The main goal is to see how many patients have their tumors shrink significantly after 4 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
EXL01 (a live bacterial product taken as a pill)
What this could lead to
If it works, this could point toward a way to boost the effectiveness of standard immunotherapy and chemotherapy for advanced gastric cancer.
What could go wrong
This is a small, early-phase trial (120 people) testing a novel approach. The gut bacteria intervention may not improve outcomes and could cause unexpected side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE NANCY Site Brabois
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, France
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Centre Antoine Lacassagne
RECRUITINGNice, France
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Centre Francois Baclesse
NOT_YET_RECRUITINGCaen, France
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Centre Georges Francois Leclerc
RECRUITINGDijon, France
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Centre Hospitalier Cochin
NOT_YET_RECRUITINGParis, France
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Centre Hospitalier Henri Mondor
NOT_YET_RECRUITINGCréteil, France
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Centre Hospitalier Saint-Malo
NOT_YET_RECRUITINGSt-Malo, France
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Centre Hospitalier Universitaire Clermont Ferrand - Site Estaing
NOT_YET_RECRUITINGClermont-Ferrand, France
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Centre Hospitalier Universitaire Grenoble Alpes - Site Nord - Hopital Michallon
NOT_YET_RECRUITINGLa Tronche, France
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Centre Hospitalier Universitaire Jean Minjoz
RECRUITINGBesançon, France
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Centre Hospitalier Universitaire Morvan
NOT_YET_RECRUITINGBrest, France
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Centre Hospitalier Universitaire Nantes - Hopital Hotel Dieu
NOT_YET_RECRUITINGNantes, France
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Centre Hospitalier Universitaire Reims Hopital Robert Debre
RECRUITINGReims, France
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Centre Hospitalier Universitaire Tours - Hopital Trousseau
NOT_YET_RECRUITINGTours, France
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Centre Hospitalier Universitaire de Lille
RECRUITINGLille, France
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Centre Hospitalier Universitaire de Montpellier
NOT_YET_RECRUITINGMontpellier, France
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Centre Hospitalier Universitaire de Poitiers - Hopital de La Miletrie
RECRUITINGPoitiers, France
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Centre Hospitalier Universitaire de Rennes
NOT_YET_RECRUITINGRennes, France
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Centre Hospitalier de Cholet
RECRUITINGCholet, France
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Clinique Sainte Catherine
RECRUITINGAvignon, France
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Groupe Hospitalier Diaconesses Croix Saint-Simon
NOT_YET_RECRUITINGParis, France
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Hopital D'Instruction Des Armées Bégin
NOT_YET_RECRUITINGSaint-Mandé, France
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Hopital Europeen Georges Pompidou
NOT_YET_RECRUITINGParis, France
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Hopital La Timone
NOT_YET_RECRUITINGMarseille, France
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Hopital Leon Berard
RECRUITINGLyon, France
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Hopital Paul Brousse
RECRUITINGVillejuif, France
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Hopital Prive Jean Mermoz
NOT_YET_RECRUITINGLyon, France
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Hopital Saint Antoine
RECRUITINGParis, France
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Hopital Saint-Louis
NOT_YET_RECRUITINGParis, France
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Institut Bergonie
NOT_YET_RECRUITINGBordeaux, France
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Institut Curie
NOT_YET_RECRUITINGParis, France
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Institut Gustave Roussy
NOT_YET_RECRUITINGParis, France
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Institut Jean Godinot
NOT_YET_RECRUITINGReims, France
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Institut Mutualiste Montsouris
NOT_YET_RECRUITINGParis, France
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Institut de Cancerologie Strasbourg Europe
NOT_YET_RECRUITINGStrasbourg, France
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Institut de Cancerologie de L'Ouest Paul Papin
NOT_YET_RECRUITINGAngers, France
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Medipole Hopital Mutualiste Lyon-Villeurbanne
NOT_YET_RECRUITINGVilleurbanne, France
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