Gut bacteria pill could boost stomach cancer treatment

NCT ID NCT06253611

Recruiting now Disease control Sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding a daily pill containing a specific gut bacterium (EXL01) to standard immunotherapy (nivolumab) and chemotherapy (FOLFOX) can shrink tumors better than the drugs alone in people with advanced gastric cancer. About 120 participants will be randomly assigned to receive either the combination or the standard regimen. The main goal is to see how many patients have their tumors shrink significantly after 4 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EXL01 (a live bacterial product taken as a pill)
What this could lead to: If it works, this could point toward a way to boost the effectiveness of standard immunotherapy and chemotherapy for advanced gastric cancer.
What could go wrong: This is a small, early-phase trial (120 people) testing a novel approach. The gut bacteria intervention may not improve outcomes and could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric carcinoma gastric neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER

Contacts and locations

Locations

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE NANCY Site Brabois
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, France
Centre Antoine Lacassagne
RECRUITING

Nice, France
Centre Francois Baclesse
NOT_YET_RECRUITING

Caen, France
Centre Georges Francois Leclerc
RECRUITING

Dijon, France
Centre Hospitalier Cochin
NOT_YET_RECRUITING

Paris, France
Centre Hospitalier Henri Mondor
NOT_YET_RECRUITING

Créteil, France
Centre Hospitalier Saint-Malo
NOT_YET_RECRUITING

St-Malo, France
Centre Hospitalier Universitaire Clermont Ferrand - Site Estaing
NOT_YET_RECRUITING

Clermont-Ferrand, France
Centre Hospitalier Universitaire Grenoble Alpes - Site Nord - Hopital Michallon
NOT_YET_RECRUITING

La Tronche, France
Centre Hospitalier Universitaire Jean Minjoz
RECRUITING

Besançon, France
Centre Hospitalier Universitaire Morvan
NOT_YET_RECRUITING

Brest, France
Centre Hospitalier Universitaire Nantes - Hopital Hotel Dieu
NOT_YET_RECRUITING

Nantes, France
Centre Hospitalier Universitaire Reims Hopital Robert Debre
RECRUITING

Reims, France
Centre Hospitalier Universitaire Tours - Hopital Trousseau
NOT_YET_RECRUITING

Tours, France
Centre Hospitalier Universitaire de Lille
RECRUITING

Lille, France
Centre Hospitalier Universitaire de Montpellier
NOT_YET_RECRUITING

Montpellier, France
Centre Hospitalier Universitaire de Poitiers - Hopital de La Miletrie
RECRUITING

Poitiers, France
Centre Hospitalier Universitaire de Rennes
NOT_YET_RECRUITING

Rennes, France
Centre Hospitalier de Cholet
RECRUITING

Cholet, France
Clinique Sainte Catherine
RECRUITING

Avignon, France
Groupe Hospitalier Diaconesses Croix Saint-Simon
NOT_YET_RECRUITING

Paris, France
Hopital D'Instruction Des Armées Bégin
NOT_YET_RECRUITING

Saint-Mandé, France
Hopital Europeen Georges Pompidou
NOT_YET_RECRUITING

Paris, France
Hopital La Timone
NOT_YET_RECRUITING

Marseille, France
Hopital Leon Berard
RECRUITING

Lyon, France
Hopital Paul Brousse
RECRUITING

Villejuif, France
Hopital Prive Jean Mermoz
NOT_YET_RECRUITING

Lyon, France
Hopital Saint Antoine
RECRUITING

Paris, France
Hopital Saint-Louis
NOT_YET_RECRUITING

Paris, France
Institut Bergonie
NOT_YET_RECRUITING

Bordeaux, France
Institut Curie
NOT_YET_RECRUITING

Paris, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Paris, France
Institut Jean Godinot
NOT_YET_RECRUITING

Reims, France
Institut Mutualiste Montsouris
NOT_YET_RECRUITING

Paris, France
Institut de Cancerologie Strasbourg Europe
NOT_YET_RECRUITING

Strasbourg, France
Institut de Cancerologie de L'Ouest Paul Papin
NOT_YET_RECRUITING

Angers, France
Medipole Hopital Mutualiste Lyon-Villeurbanne
NOT_YET_RECRUITING

Villeurbanne, France

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