New biologic TRK-950 joins forces with standard chemo to fight stomach cancer
NCT ID NCT06038578
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding an experimental biologic called TRK-950 to the standard combination of ramucirumab and paclitaxel helps people with advanced stomach or gastroesophageal junction cancer. Participants receive either the standard two-drug regimen or the standard regimen plus TRK-950 at one of two dose levels. The study measures how long the cancer stays under control, overall survival, and tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TRK-950 (a biologic) plus ramucirumab and paclitaxel
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced gastric cancer that has worsened after prior therapy.
What could go wrong
This is an early-phase trial with a small number of participants. The experimental drug may not improve outcomes and could cause side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASAN Medical Center
RECRUITINGSeoul, 05505, South Korea
Contact
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Chonnam National University Hwasun Hospital
RECRUITINGHwasun, Jeollanam-do, 58128, South Korea
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City of Hope
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-••••
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City of Hope at Orange County Lennar Foundation Cancer Center
RECRUITINGIrvine, California, 92618, United States
Contact Phone: •••-•••-••••
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Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
RECRUITINGYokohama, Kanagawa, 241-8515, Japan
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Kyungpook National University Chilgok Hospital
RECRUITINGDaegu, 41404, South Korea
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National Cancer Center Hospital
RECRUITINGChūōku, 104-0045, Japan
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National Cancer Center Hospital East
RECRUITINGKashiwa, 277-8577, Japan
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Osaka International Cancer Institute
RECRUITINGChūōku, 541-8567, Japan
Contact
Contact
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Saitama Prefectural Hospital Organization Saitama Cancer Center
RECRUITINGShinden, Saitama, 362-0806, Japan
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13605, South Korea
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Severance Hospital
RECRUITINGSeoul, 03722, South Korea
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Shizuoka Cancer Center
RECRUITINGNagaizumi-cho, Shizuoka, 411-8777, Japan
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Texas Oncology Arlington North
RECRUITINGArlington, Texas, 76012, United States
Contact Email: •••••@•••••
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Texas Oncology Bedford
RECRUITINGBedford, Texas, 76022, United States
Contact Email: •••••@•••••
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Texas Oncology Dallas Medical City
RECRUITINGDallas, Texas, 75230, United States
Contact Email: •••••@•••••
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Texas Oncology Dallas Methodist
RECRUITINGDallas, Texas, 75203, United States
Contact Email: •••••@•••••
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Texas Oncology Dallas Presbyterian
RECRUITINGDallas, Texas, 75231, United States
Contact Email: •••••@•••••
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Texas Oncology Fort Worth Cancer Center
RECRUITINGFort Worth, Texas, 76104, United States
Contact Email: •••••@•••••
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Texas Oncology Grapevine
RECRUITINGGrapevine, Texas, 76051, United States
Contact Email: •••••@•••••
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Texas Oncology Methodist Charlton Cancer Center
RECRUITINGDallas, Texas, 75237, United States
Contact Email: •••••@•••••
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Texas Oncology Plano East
RECRUITINGPlano, Texas, 75075, United States
Contact Email: •••••@•••••
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Texas Oncology Plano West
RECRUITINGPlano, Texas, 75093, United States
Contact Email: •••••@•••••
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Texas Oncology-Sammons Cancer Center
RECRUITINGDallas, Texas, 75246, United States
Contact Phone: •••-•••-••••
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The Cancer Institute Hospital of JFCR
RECRUITINGKōtoku, 135-8550, Japan
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University of California, Los Angeles
RECRUITINGSanta Monica, California, 90404, United States
Contact Phone: •••-•••-••••