Drug dependence

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This study tests a program called MOMENT-V that combines two counseling sessions with a smartphone app to help young adults reduce cannabis use. About 65 participants will either use the full program or have a brief counseling session. Researchers will check if the program is eas…

This trial tests whether adding substance use disorder resources to existing behavioral health services in pediatric primary care clinics can improve care for adolescents with opioid use disorder. The approach includes training, stigma reduction, and brief interventions during re…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This trial tests whether giving naloxone — the opioid-overdose reversal drug — just before buprenorphine can help people who use fentanyl start addiction treatment more quickly and with less discomfort. The study enrolls a small group of adults with opioid use disorder who test p…

This study tests whether a telehealth-delivered counseling program, called VetReach, can help veterans with opioid use disorder engage in treatment and improve their outcomes. The program combines motivational interviewing and cognitive behavioral therapy, delivered remotely. Res…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study tests whether a brief screening and a telehealth counseling session in the emergency department can help people reduce their use of drugs or alcohol. About 650 adults who are at low or moderate risk for substance use problems will take part. The goal is to see if this …

This study tests different medication and counseling combinations to improve how long people stay in treatment for opioid use disorder and whether they can safely stop medication without relapsing. Over 1,500 participants choose either buprenorphine or naltrexone and are randomly…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests a program where pharmacists provide weekly phone coaching to adults who may be misusing opioid medications. The goal is to reduce risky opioid use and prevent addiction. 350 participants across 14 pharmacies are taking part in this randomized trial.

This study looks at whether varenicline (a prescription drug) or nicotine patches help people quit smoking more effectively, depending on their natural levels of emotion and attention. About 204 smokers aged 18-75 who smoke at least 5 cigarettes daily will receive behavioral coun…

This study tests whether a mobile app can help adults in Singapore quit smoking. About 100 participants will be randomly assigned to receive the app-based support or standard care, and researchers will track how many stay smoke-free for 6 months. The goal is to see if this approa…

This study investigates whether using an electronic cigarette, along with a nicotine patch, can lessen smokers' automatic reactions to smoking-related cues like seeing someone smoke or smelling cigarette smoke. The researchers will measure these reactions through questionnaires, …

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study tests whether daily text check-ins and small financial rewards can help people with opioid use disorder stay engaged in treatment after leaving the emergency department. Participants receive automated texts for 30 days and can contact a navigator for support, while som…

This Phase 3 trial tests whether a combination of extended-release naltrexone (Vivitrol) and bupropion XL (Wellbutrin) can help people with moderate to severe methamphetamine use disorder reduce their drug use. About 360 participants will receive either the active drugs or placeb…

This study tests whether a long-acting buprenorphine injection can be used to start treatment for opioid use disorder without causing severe withdrawal. Thirty adults with opioid use disorder will stay in a hospital for three days, receive fentanyl to prevent withdrawal, and then…

This study tests a structured, 8-week smoking cessation program delivered via weekly video group sessions. It enrolls adults addicted to nicotine who want to quit. Researchers track whether participants stay smoke-free six months after the program ends, and how their anxiety and …

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This pilot study tests a new way to help adults aged 50 and older quit smoking. Participants interact with a virtual counselor on a computer, receive nicotine patches and gum or lozenges, and get support from a community health worker who also helps them schedule lung cancer scre…

This study tests whether combining home food delivery with video-based smoking cessation counseling helps rural smokers quit more than counseling or food delivery alone. Participants are adults aged 21-75 who smoke regularly and live in certain Arkansas counties. The goal is to s…

This study tests a non-invasive brain stimulation technique called targeted temporal interference stimulation (tTIS) aimed at the caudate nucleus. The goal is to reduce drug cravings and improve decision-making in 60 adults with methamphetamine use disorder. Participants will rec…

This study will test whether using opioid-free anesthesia during knee replacement surgery can reduce the risk of long-term opioid use and chronic pain. About 700 adults scheduled for knee replacement will be randomly assigned to receive either standard opioid-based anesthesia or …

This study tests a telehealth program called the Ria Treatment Platform for people with alcohol use disorder. Participants receive medication, coaching, educational videos, and a Bluetooth breathalyzer through their phone. The goal is to see if this approach helps reduce heavy dr…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests a smoking cessation program called All Nations Breath of Life, designed specifically for American Indian communities. It involves 576 participants at four sites—two on reservations and two in urban areas. The program includes counseling and support, and success i…

This pilot study aimed to help people who had an opioid overdose by starting them on buprenorphine/naloxone in the emergency room and then connecting them to an addiction clinic. The goal was to reduce repeat overdoses and improve treatment engagement. However, the study was with…

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This study tests a telephone-based version of the All Nations Breath of Life program, designed specifically for American Indians who smoke. Participants receive coaching calls over the phone and are compared to those in a general smoking cessation program. The main goal is to see…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This study tests whether adding peer recovery support—coaching from someone who has personally overcome opioid addiction—to standard medication treatment (buprenorphine) helps people stay in care longer. Fifteen adults with opioid use disorder will receive peer support for 180 da…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This early-stage study tests a gene therapy given through an IV for adults with cocaine use disorder who are in remission. The therapy helps the body produce an enzyme that breaks down cocaine quickly, reducing the drug's pleasurable effects. The main goal is to check safety, wit…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This study tests whether a smartphone app can help people on medication for opioid use disorder stay drug-free. The app tracks location and sends alerts when users enter high-risk areas. Researchers will also use brain scans to understand why some people do better than others. Th…

This study looks at whether helping both patients and their household members quit smoking together works better than helping patients alone. About 231 patients who smoke and live with other smokers will get nicotine replacement therapy and support. Researchers will check quit ra…

This study looks at whether allowing regular cannabis users to buy regulated cannabis from pharmacies helps them switch to safer ways of using it, like vaping or edibles, instead of smoking. About 1,177 participants in Switzerland are randomly assigned to buy from pharmacies or s…

This study tests a simple alert built into hospital electronic health records. When a doctor writes a note for a patient who smokes, the alert automatically suggests prescribing nicotine replacement therapy and ordering lung cancer screening. The goal is to see if this reminder h…

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This study tests whether adding culturally-aligned activities and healing groups to standard medication-assisted treatment (MAT) helps people with opioid use disorder stay in treatment longer and reduce harm. About 136 adults newly enrolled in the Cherokee Nation MAT program will…

This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. 240 participants from Maryland jails will receive monthly shots for six months after release. The go…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This pilot study tests a web-based program called LDART for adults with stimulant use disorder (cocaine or methamphetamine). The program includes daily goal setting, motivational messages from people in recovery, and links to support groups. Researchers want to see if it's feasib…

This study looks at whether offering money can help hospitalized smokers quit. Over 1,000 adult smokers will be given different types of financial rewards to see which approach works best. The goal is to find a cost-effective way to help people stop smoking for good.

This study tests whether giving a long-acting buprenorphine shot (BRIXADI) via telemedicine to 30 jailed adults with opioid use disorder helps them stay on treatment after release. Participants switch from daily pills to weekly or monthly shots before leaving jail, then continue …

This early-stage trial tests whether psilocybin, the active ingredient in magic mushrooms, combined with psychotherapy can help veterans with moderate to severe methamphetamine use disorder. Thirty participants will receive either psilocybin-enhanced therapy or standard treatment…

This study looks at two different approaches to help community hospitals start treating opioid use disorder in patients. One approach is basic training and education, while the other adds extra support like practice facilitation. The goal is to see which method works better at ge…

This study tests whether an online training program helps people who recently quit smoking stay smoke-free and also support others in their social network to quit. About 940 adults who have been smoke-free for 2 to 8 weeks will take part. They will complete online surveys and pro…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests whether a 90-day Mediterranean diet can lower drug cravings and improve blood health in people being treated for opioid addiction with methadone or buprenorphine. Forty adults will either follow the diet or eat as usual. The goal is to see if better nutrition can…

This study compares two approaches to helping smokers quit: an opt-out method where everyone is automatically referred unless they say no, versus an opt-in method where people must actively sign up. Over 1,300 veterans at VA clinics in New York are taking part. The goal is to see…

This study compares two approaches to help people who are homeless or at risk of homelessness quit smoking: cytisine (a plant-based pill) versus nicotine replacement therapy (like mouth spray, patches, or gum). Both groups also get counseling. The goal is to see which strategy wo…

This study aimed to test whether exenatide (Bydureon), a drug approved for type 2 diabetes, could safely reduce the urge to use cocaine. Researchers planned to give the drug or a placebo to people with cocaine use disorder and measure how many cocaine doses they chose to take. Ho…

This study aimed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to enroll adults aged 21–70 who were not already on opi…

This study tests whether a daily kava drink can help active smokers who don't plan to quit reduce their smoking and lower their risk of lung cancer. Twenty adult smokers will take kava daily for several months. Researchers will check how well participants stick with the regimen, …

This study tests whether a smartphone app can help people with opioid use disorder stay drug-free. Participants use the app to submit video-recorded saliva drug tests, earn rewards for staying abstinent, complete therapy modules, and get support from a peer. The study involves 25…

This study looked at whether giving a short-term buprenorphine treatment to people on probation or parole with opioid use disorder helps them stop using illegal opioids and get into long-term care. About 320 adults in Baltimore took part. The approach was compared to simply refer…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study compares cannabidiol (CBD) to the standard antipsychotic risperidone in 64 adults with schizophrenia or related psychotic disorders who have used cannabis. The goal is to see if CBD can reduce psychotic symptoms and help people stop or cut down cannabis use. Participan…

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study compares standard emergency department care to an extended observation period for people with opioid use disorder. Participants are randomly assigned to either leave after a regular ED visit or stay longer in an observation unit to receive their first dose of buprenorp…

This study aimed to compare two ways of managing pain after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would receive a lower dose around the time of surgery. The goal was to see which approach better …

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people with nicotine or substance use disorders who are homeless or low-income. Researchers want to see if this approach improves quality of life and helps…

This study tests a program called ED-LINC that starts in the emergency room for people with opioid use disorder. The program offers overdose education, motivation to seek help, help choosing medication, and three months of follow-up care. Researchers want to see if this approach …

This trial tests a digital program designed to help people quit tobacco. Over 2,200 participants will use the program or receive usual care. The main goal is to see if the program helps people stop using their primary tobacco product for at least 30 days.

This study tests a program that connects pregnant women with opioid use disorder to a team of doctors, peer supporters, and community resources like doulas and home visiting. The goal is to improve treatment during pregnancy and reduce the need for medication in newborns experien…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This study tests a program called HEROES that combines medication (Suboxone), counseling, and community outreach to help people with opioid use disorder engage and stay in treatment. Researchers will enroll 3,000 participants in Houston to see if this approach improves treatment …

This study is creating and testing a program to help Hispanic/Latino high school students stop using e-cigarettes. Researchers will work with 120 teens to see if the program is practical and helps reduce vaping. The goal is to support a group that is often overlooked in quitting …

This study tests a program called BAT-CS that combines smoking cessation counseling with mood management for people who have had a heart attack (acute coronary syndrome). The goal is to help them quit smoking and reduce depression symptoms, which could lower their risk of dying f…

This trial tests whether a school-based program can help parents stop smoking. About 700 families with a smoking parent will take part. The program includes education, motivation support, and relapse prevention delivered both in person and online. Success is measured by whether p…

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study tests whether a robot-assisted escape room game can help 5th and 6th graders learn about the harms of tobacco and e-cigarettes. About 200 students in Taiwan will either play the game or receive standard classroom lessons. Researchers will measure changes in knowledge, …

This study tests whether training store staff and increasing enforcement can reduce marijuana sales to obviously-intoxicated customers. Researchers will send actors pretending to be drunk to buy marijuana and see if stores refuse the sale. The goal is to prevent impaired driving …

This study tests a free online program called Healthy Futures: Alternative-to-Suspension, designed to teach high school students about the risks of tobacco and nicotine and provide resources to quit. About 2,540 students from schools that agree to use the program or continue thei…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study is testing whether a smartphone app, combined with nicotine patches, can help people reduce or quit smoking. The app guides users to smoke on a schedule and tracks their progress. The study involves 56 adult smokers who smoke at least 10 cigarettes a day. The goal is t…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This study asks whether standard residential treatment for substance use disorders can improve a person's ability to empathize with others. Researchers will measure empathy levels in about 108 adults before and after they complete a residential program followed by partial hospita…

This study tests whether a short, group-based stress management training program can help caregivers of people with methamphetamine ("ice") addiction and psychosis. Caregivers often face high levels of emotional and physical stress, which can lead to burnout. The program teaches …

This small pilot study tests whether using a mobile app can help adults quit smoking. About 24 smokers from MD Anderson's Tobacco Treatment Program will use either a positive psychology app or a relaxation app alongside their usual care. The main goal is to see how well people st…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study tests whether suvorexant, a drug used for insomnia, can reduce nicotine cravings and withdrawal symptoms in daily smokers. Participants, who smoke at least 5 cigarettes a day and are nicotine-dependent, will receive either a low or high dose of suvorexant or a placebo.…

This study tests whether increasing the dose of varenicline or adding bupropion helps people with recurrent acute or chronic pancreatitis quit smoking. All 45 participants start with standard varenicline; those still smoking after 6 weeks are randomly assigned to a higher dose, a…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests whether a type of counseling called behavioral activation therapy, combined with a nicotine patch, helps people quit smoking. It focuses on smokers who have low reward sensitivity, meaning they get less pleasure from rewards. About 85 participants will receive ei…

This study looks at whether a mobile mindfulness app (Headspace) can help people being treated for opioid use disorder who also have a history of childhood trauma. Sixty participants will be asked to use the app daily for 30 days and visit the clinic four times to check stress le…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether an adapted version of Cognitive Processing Therapy (CPT), delivered via telehealth at syringe service programs, can reduce PTSD symptoms and help people stay on their opioid use disorder medication. Eleven adults who regularly use syringe services and are…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests a text-message counseling program designed to help young adults ages 18 to 25 reduce or stop their cannabis use. Participants must use cannabis at least three days a week and live in Tennessee or Colorado. The program uses peer support and counseling delivered vi…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants are guided to vividly imagine positive future events that could result from quitting, combined with brief smoking cessation counseling. The t…

This pilot study tests whether two smartphone apps can help current smokers quit. 24 participants will use either the KickAsh app (to track mood and activity) or the Breathe2Relax app (for relaxation). Researchers will check if the apps improve mood, increase activity, and lead t…

This study tests a new sublingual film called BXCL501 (dexmedetomidine) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, muscle pain, and nausea. About 160 adults with opioid use disorder will receive the drug, a placebo, or an existing medication (lofexidine…

This study aimed to see if adding dexmedetomidine to a standard painkiller could improve pain control and comfort after lung surgery in smokers. It planned to enroll 102 men with high nicotine dependence. However, the study was withdrawn before any participants were enrolled, so …

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be safely given to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study aimed to compare two pain medicines given into the spinal fluid during C-section for patients with opioid use disorder who take buprenorphine. It planned to enroll about 0 participants and measure pain scores and recovery. However, the trial was withdrawn before any pa…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder symptoms in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete tests and questionnaires. The goal is to see if one compound he…

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study tests whether a pharmacist-led program can help low-income smokers use nicotine patches or lozenges to quit or reduce smoking. About 100 adults from community health centers will receive counseling sessions and text support. The goal is to see if this approach is pract…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study tests a device called NET that uses mild electrical stimulation to reduce opioid withdrawal symptoms. It involves 108 adults who want to stop using opioids without taking other medications. Participants are randomly assigned to get real or sham device treatment, and re…

This study tests whether a short group therapy program (CBT) can help men in prison stop smoking. 202 participants will be randomly assigned to CBT, a health education session, or a waitlist. Researchers will check if they quit by measuring carbon monoxide levels at 1 and 3 month…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study aims to find out how many pregnant women in Slovenia use alcohol or cannabis by testing their newborns' first stool (meconium) and asking mothers to fill out a survey. Researchers will also compare the gut bacteria of babies exposed to these substances with those who w…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study tests a new imaging tracer called [18F]fluortriopride to see if it can clearly show D3 dopamine receptors in the brain. Researchers will compare brain scans from healthy volunteers and people with cocaine dependence, and also check how consistent the tracer's signals a…

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

This study looks at whether adult smokers who switch to a heated tobacco device (called THS or TP18) have lower levels of harmful chemicals in their body compared to those who keep smoking regular cigarettes. About 108 smokers will be monitored over a week in a clinic and then at…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study looked at how adults who smoke cigarettes daily or only some days might react if certain tobacco products were no longer available. Researchers created a pretend online store where participants could shop for cigarettes and other nicotine products under different rules…

This study looks at how the labels and marketing claims on cannabis products affect what people think about the product's risks and effects. About 2,000 adults in states where recreational cannabis is legal will answer online survey questions after viewing a cannabis advertisemen…

This study develops and tests a computer tool that helps pharmacists screen patients for opioid medication risks. Researchers will compare pharmacies using the tool to those using standard care. The goal is to see if the tool lowers patients' risk of opioid abuse.

This observational study follows pregnant women with opioid use disorder who are taking buprenorphine or methadone. Researchers use MRI scans of the placenta and fetal brain during the second and third trimesters, along with blood samples and developmental assessments after birth…

This study tests whether a coaching program called COSTARS helps child welfare supervisors better support their teams, including caseworkers and peer mentors with lived recovery experience. About 200 supervisors in Ohio's START program will either receive coaching or continue usu…

This phase 1 study evaluates the safety and tolerability of BRC-002, an investigational cannabis-derived botanical drug, in healthy adults aged 18 to 55. Researchers will also examine how the body processes the drug and whether food affects its absorption. The results will guide …

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This study aims to validate two new tools that use artificial intelligence to predict a person's risk of developing opioid use disorder. One tool looks at genetic markers, and the other examines gut bacteria. Researchers will enroll 300 adults with or without opioid addiction to …

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study follows adults who have knee replacement surgery using a fast-track recovery program called ERAS. Researchers want to know how many people still have pain three months later, how severe it is, and whether they still need strong painkillers. Participants answer simple q…

This study looks at how proposed tobacco regulations might affect the buying and use habits of people in Appalachian Kentucky. About 473 adults who use tobacco daily will take online surveys and shop in a pretend online store where prices change. The goal is to see if rules like …

This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and pu…

This study tests whether doing clinical trial visits remotely (from home) works as well as coming into a clinic. About 200 adults will be randomly assigned to remote or in-person groups for intake and follow-up over 3 months. The goal is to see which method is better at keeping p…

This study looks at how long-term exposure to secondhand tobacco smoke changes the lungs of never-smoking flight attendants who worked on planes before smoking was banned. Researchers want to see if a bronchodilator, a medicine that opens airways, can help with breathing problems…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study tracks 2,500 people with HIV in Brazil who are taking a common first-line treatment (tenofovir/lamivudine and dolutegravir) to see why some develop drug resistance. Researchers will test blood samples from those whose viral load remains detectable to look for resistanc…

This study looks at how different warning labels on cannabis edibles packaging change what people know, how safe they think the product is, and whether they want to try it. About 1,250 adults in the U.S. will view packages with different warnings and answer questions. The goal is…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…

This study looks at whether a mobile peer support app can help people who have been in jail or prison and are recovering from opioid use disorder feel more connected and less lonely. About 90 adults who recently took medication for opioid use disorder while incarcerated will use …

This study looks at medical records of 50 cancer patients who say cannabis helped stop their tumor from growing or shrank it. Researchers want to see if there is real evidence behind these claims. The goal is to gather information, not to test a new treatment.

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study looks at how cannabis use changes natural brain chemicals in adolescents aged 14 to 25. Researchers will measure cannabinoid and endorphin levels in blood to find markers that could tell which teens might relapse and which stay sober. The goal is to better understand c…

This study looks at how small amounts of alcohol and THC (the active part of cannabis) affect driving in a simulator. Forty adults aged 21 to 55 who have used both substances before will take part. The goal is to understand how these drugs change driving performance and thinking,…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 occasional cannabis users who also drink alcohol will use a driving simulator after taking controlled doses. The goal is to understand the risks of driving under the inf…

This observational study at Yale uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these receptors are lower in users and how that relates to thinking skills and brain rhythms during withdra…

This study looks at how alcohol and cannabis, alone or together, affect driving and thinking. About 40 occasional users aged 21–55 will take part. They will inhale low-dose THC (like a quarter of a joint) and drink alcohol, then test their driving on a simulator and complete ques…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 adults aged 21–55 who have used both substances before will take part. They will complete simulated driving tests and questionnaires after receiving the substances. The …

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study looks at what happens when people who use cannabis regularly take it daily for two weeks. Researchers will measure pain sensitivity, feelings of a 'good drug effect,' and natural cannabis-like chemicals in the blood. The goal is to understand if daily use changes pain …

This study looks at whether young adults (ages 21-25) who use high-potency cannabis concentrates can improve their memory and thinking by switching to less potent products. Researchers will test participants' cognitive performance and collect blood and urine samples. The goal is …

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This pilot study will use special PET scans to measure opioid receptor binding in the brain, spinal cord, and other organs in up to 60 adults, including healthy volunteers and people with opioid use disorder. The goal is to better understand how opioids affect the whole body, not…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study tests whether a job coaching program called Individual Placement and Support (IPS) helps veterans with opioid use disorder find and keep competitive jobs. Researchers will compare IPS to standard vocational rehab in 123 veterans. They also want to see if getting a job …

This study tests a training program called PATH, designed to help peer recovery support specialists who deliver harm reduction services. The program includes online lessons and group meetings to discuss real-life cases. Researchers want to see if it reduces burnout and improves t…

This study was designed to understand how cigarette direct mail marketing influences smoking beliefs and behavior in young adults ages 18 to 29. Researchers planned to compare responses between smokers from higher and lower income backgrounds. However, the study was withdrawn bef…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study follows 100 head and neck or lung cancer patients who are current or former smokers and receive radiation therapy. Researchers track who stays smoke-free at 1, 6, and 12 months after treatment ends, and what factors help or hinder abstinence. The goal is to learn how t…

This study tests whether an online support program called HOPE can help people with opioid use disorder ask for medication treatment. Researchers will assign 640 participants to either the HOPE online community or a control group and track how many request information about medic…

This study looks at how different types of cannabis oil (high or low CBD-to-THC ratio) affect stress and self-control in healthy adults aged 19-35 who use cannabis occasionally. Participants will undergo brain scans and stress tests to measure changes in brain activity, stress ho…

This study aimed to see if a drug called AEF0117 changes how the body processes THC from cannabis. It was designed for healthy adults aged 21-55 who use cannabis. The trial was withdrawn before enrolling anyone, so no results are available.

This study tests whether a "Care Navigator" — a personal guide — can help people with substance use problems start and stay in treatment. About 360 adults who call a mental health access center will be randomly assigned to get usual care or extra help from a navigator. The goal i…

This study aims to understand why some people with opioid use disorder have more severe addiction than others. Researchers will collect blood, saliva, and hair samples from 350 participants and combine that with detailed interviews about their social and mental health. The goal i…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll 30 patients and 5-10 staff, giving patients the combined injections and following up …

This study tests whether giving doctors brief education and feedback on their opioid prescribing habits leads to safer prescribing. About 52 primary care clinics are involved. The goal is to reduce inappropriate opioid use and lower the risk of addiction.

This study looks at how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 participants, including a non-smoking group. The goal …

This study uses identical twins who both use cannabis to see if quitting for 42 days improves memory, attention, and mental health symptoms. One twin is paid to stop using cannabis, while the other continues as usual. Researchers will compare changes in thinking skills and mood b…

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…

This study is developing and testing a mobile app to teach pregnant women with opioid use disorder how to care for newborns who may experience neonatal abstinence syndrome (NAS). The app provides training on comforting techniques like swaddling, skin-to-skin contact, and feeding.…

This study looks at how different patterns of cannabis use (like how often, how long, and what type) affect anesthesia needs and inflammation in people having lumbar spine surgery. Researchers will measure the amount of anesthesia and pain medication needed during surgery, as wel…

This observational study follows 120 adult e-cigarette users for two weeks to see if those who use lower nicotine e-liquids have less nicotine exposure and fewer harmful chemicals compared to those using higher nicotine e-liquids. Participants will use their usual devices at home…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with opioid use disorder stick with their methadone treatment and avoid relapse. Researchers will measure how stress affects cravings and decision-making. 32 adults currently in methad…

This study aimed to see if a non-invasive brain stimulation technique called TMS could help people with methamphetamine use disorder control their cravings. Researchers planned to recruit 40 adults living in a residential treatment program and give some real stimulation and other…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study involves 3,650 adults in 20 opioid treatment programs who are starting medication for opioid use disorder. Participants will use digital tools to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treat…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…

This study was designed to test whether a drug called lorcaserin could help people with cocaine dependence by rebalancing serotonin in the brain. Researchers planned to use brain scans to see if the drug reduced cravings and impulsivity. However, the study was withdrawn before en…

This study looks at how people's bodies react to stress in a pretend emergency room. Researchers will have 30 adults (20 who use meth and 10 healthy volunteers) do public speaking and math tasks while measuring stress hormones, heart rate, and blood pressure. The goal is to see i…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…

This study follows 400 adults receiving standard treatment for prescription narcotic drug use disorder, including opioids and benzodiazepines. Researchers will measure how many patients reduce or stop using these drugs and what factors help. No new treatments are tested; the goal…

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…