Magic mushroom therapy takes on meth addiction in veterans

NCT ID NCT04982796

Ongoing Disease control Sponsor: Portland VA Research Foundation, Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether psilocybin, the active ingredient in magic mushrooms, combined with psychotherapy can help veterans with moderate to severe methamphetamine use disorder. Thirty participants will receive either psilocybin-enhanced therapy or standard treatment. The study focuses on whether the approach is safe, acceptable, and feasible, not yet on proving it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If this works, it could point toward a new treatment option for methamphetamine use disorder, potentially helping people reduce or stop use.
What could go wrong: This is a very early, small proof-of-concept study with only 30 veterans. It primarily measures safety and feasibility, not effectiveness. Psilocybin may cause adverse events or not show benefit over usual care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AMPHETAMINE-RELATED DISORDERS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

amphetamine abuse methamphetamine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPHETAMINE-RELATED DISORDERS

Contacts and locations

Locations

Portland VA Health Care System

Vancouver, Washington, 98661, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.