Drug dependence

This 12-week study tests whether a weekly injection of tirzepatide, a drug used for diabetes, combined with motivational therapy can help adults with moderate to severe cannabis use disorder. Fifteen participants will receive escalating doses of tirzepatide along with counseling.…

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This study tests whether peer recovery coaches—people who have personally overcome opioid addiction—can help others with opioid use disorder quit smoking. About 60 adults on medication for opioid use disorder who smoke daily will receive either coaching from a peer coach or stand…

This study will test whether cannabis can reduce the severity of opioid withdrawal and make opioid use safer. One hundred adults with opioid use disorder will live in a hospital for about six weeks. Researchers will give them cannabis and a small dose of opioids to see how their …

This phase 2 trial will test whether semaglutide, the drug in Ozempic, can help people with methamphetamine use disorder cut down their use. Forty adults who use methamphetamine at least 14 days per month will receive weekly injections for 12 weeks. The study will check if the tr…

This study tests whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay on medication for opioid use disorder compared to referring them elsewhere. About 512 adults who use SSPs and have moderate to severe opioid use …

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests whether the drug varenicline (Chantix) can help veterans who smoke at least 5 cigarettes a day but aren't ready to quit. Participants will either take varenicline or use nicotine lozenges to reduce smoking over 12 weeks. The goal is to see if this approach leads …

This study tests a combination of telehealth, peer support, and medication (buprenorphine) to help people with opioid use disorder stay in treatment after leaving the emergency room. The goal is to reduce repeat overdoses and prevent deaths. About 160 adults who have had an opioi…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This study tests whether cannabis-based treatments can safely reduce seizures in people aged 2 to 55 with drug-resistant epilepsy. Participants will receive either a pure CBD extract, a CBD-rich herbal cannabis extract, or a placebo. The goal is to see if these treatments lower m…

This early-phase trial will test the safety and blood levels of an investigational drug called MCAM in 24 healthy adults. Participants will receive a single dose of MCAM or a placebo and be monitored for 8 days. The goal is to find the highest safe dose for future studies on opio…

This pilot study will develop and test a telehealth program designed to help marginalized patients access and stay in treatment for opioid use disorder. Researchers will enroll 60 people—half already in treatment and half not yet in treatment—and provide them with a user-friendly…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can strengthen a brain circuit linked to staying away from cannabis. Fifty treatment-seeking youth aged 15–21 with cannabis use disorder will receive either real or sham rTMS. Researchers will chec…

This study tests whether adding two FDA-approved cannabinoids—dronabinol (synthetic THC) and epidiolex (CBD)—to standard buprenorphine treatment can help people with opioid use disorder stay in treatment and reduce opioid use. The trial will enroll 40 adults who recently started …

This trial investigates whether Cobenfy, a medication typically used for schizophrenia, can reduce the rewarding effects of cocaine in people with cocaine use disorder. Over an 11-day inpatient stay, participants receive either Cobenfy or a placebo twice daily, then take part in …

This study tests two behavioral interventions—Behavioral Activation (finding enjoyable activities) and Attendance Reinforcement (vouchers for showing up)—to help people with opioid use disorder stay on buprenorphine treatment for at least 6 months. Researchers will enroll 240 adu…

This study tests a very brief smoking cessation intervention called 3A-OR in family health centers across Turkey. About 2,400 smokers aged 15 and older will be randomly assigned to receive the intervention or usual care. The intervention involves asking about tobacco use, assessi…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether completing methadone clinic intake during a hospital stay helps people with opioid use disorder stay connected to treatment after leaving. Researchers will compare usual care (a referral at discharge) to a program where hospital staff complete key steps l…

This study tests whether patient navigation—a series of coaching sessions—helps pregnant women with opioid use disorder stay in treatment and reduce drug use. About 429 pregnant women will be randomly assigned to either usual care or patient navigation, which includes up to 14 se…

This study tests a text- and web-based tool called FamilyCHESS, designed to help people with moderate to severe opioid use disorder begin and stay on medication. The tool also involves a concerned family member or friend who provides support. Researchers will compare outcomes lik…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests a 'rapid restart' approach for people with opioid use disorder who have missed 4-8 doses of methadone. Instead of slowly increasing the dose again, participants may return to their previous stable dose right away. The goal is to see if this method is acceptable a…

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This early-stage study tests a new oral medication called VK4-116 in 48 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for opioid dependence and opioid use disorder. Participants will receive a single dose o…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This pilot study will test whether giving a monthly extended-release buprenorphine injection (BRIXADI) from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. About 60 participants will receive the shot for 6 months, and researchers will tra…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly as…

This study tests two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose start or a direct injection approach. The goal is to see which method helps people stay in treatment …

This study tests a medicine called tirzepatide to see if it can help people with moderate to severe cannabis use disorder use less cannabis or stop altogether. One hundred adults aged 18 to 70 will receive either the drug or a placebo, and researchers will track their cannabis us…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can help people with alcohol use disorder drink less. Over 12 weeks, 312 participants will receive either real or sham tDCS in 5-day clusters each month. The goal is to see if this appr…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests a biodegradable implant called OLANI that slowly releases naltrexone to block the effects of opioids for weeks. Researchers will enroll 250 adults with opioid use disorder who have already completed withdrawal. Participants will receive up to four implants over a…

This early-stage trial tests a new naltrexone implant (iSTEP-N) that slowly releases medication over 12 months to block opioids. It will enroll 33 healthy adults and compare two implant doses to standard monthly injections. The goal is to see if the implant can maintain steady dr…

This study tests whether combining ketamine-assisted psychotherapy with mindfulness training (called KetaMORE) helps people with opioid use disorder who are already on medication. 88 participants will be randomly assigned to receive either KetaMORE or ketamine with a support grou…

This study will create and test a smartphone app designed to help teenagers in Indonesia stop smoking. About 110 teens aged 13-15 who smoke will be split into two groups: one using the new app and the other using paper materials. Researchers will check if the app helps them stay …

This study tests whether adding accelerated transcranial magnetic stimulation (aTMS) to the standard smoking-cessation drug varenicline helps adults quit nicotine products like cigarettes and vapes. Thirty participants will take varenicline daily for 12 weeks and receive either r…

This study tests whether offering gift cards can help people leaving jail stick with their medication for opioid use disorder. Participants earn up to $600 for attending appointments and counseling over three months after release. The goal is to reduce the high risk of overdose d…

This pilot study tests whether tirzepatide, a drug used for diabetes, can reduce cravings in people with severe cannabis use disorder. Six adults will receive either tirzepatide or a placebo injection and then be exposed to cannabis-related cues to measure craving intensity. The …

This study tests whether offering rewards (contingency management) can help people who use methamphetamine reduce their use after a traumatic injury. Twenty adults admitted to the hospital with a positive meth test will receive urine tests and rewards for negative results, starti…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study tests whether offering medication for opioid use disorder (buprenorphine) in community settings—like churches or social service centers—via telemedicine, plus one-on-one coaching, helps people stay in treatment longer than standard clinic care. About 400 participants w…

This study tests a talking therapy called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. The therapy includes motivational interviewing and cognitive behavioral therapy in weekly sessions over 12 weeks. Researchers…

This study aims to create personalized treatment plans for people with opioid use disorder by using machine learning to find the best sequence of medications and behavioral therapy. Researchers will test these plans in a small pilot study with 75 adults to see if they are feasibl…

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests a behavioral program called contingency management for people with opioid use disorder. Participants in an inpatient unit receive small rewards when they provide drug-free urine samples. The goal is to see if this approach helps them stay abstinent during their t…

This study tests whether a monthly injection of buprenorphine (a medication for opioid dependence) works well and is affordable in low- and middle-income countries. About 760 adults who inject drugs and have opioid dependence will receive the injection and be followed for 48 week…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests whether giving financial rewards to pregnant women who smoke—and to their smoking partners—helps them quit. About 180 pregnant women and their partners will be split into three groups: one where only the woman gets money for quitting, one where both get money, an…

This study tests a smartphone game called MedSMA℞T Mobile, designed to help parents and their teenage children learn how to use, store, and dispose of opioids safely. About 244 families will play the game for 30 minutes and complete surveys over 9 months. The goal is to see if th…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This study tests whether a smartphone app with AI can help adolescents aged 14-20 quit e-cigarettes. Participants use the app to set goals, track progress, and get real-time support during cravings. Researchers compare an immediate-use group with a delayed-start group to see if t…

This study tests whether a ketone supplement drink can reduce cravings and withdrawal symptoms in adults with opioid use disorder who are undergoing detox in a treatment center. Fifty participants will receive either the ketone drink or a placebo three times daily for seven days.…

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This study tests a smartphone app called KIOS designed to help people recovering from opioid addiction manage their health. Researchers will track how well participants stay in treatment over one year and who benefits most from the app. About 134 adults who recently started bupre…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study tests whether a compound from cannabis called THCV can help people who smoke daily to resist cigarettes and smoke less. 32 smokers will receive either THCV or a placebo and then take a test measuring how long they can delay smoking and how many cigarettes they smoke. T…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This study tests whether a program that helps people notice and manage smoking triggers can help light smokers (10 or fewer cigarettes per day) quit. About 60 adults will either get standard counseling or counseling plus a cue-based tool where they text about cravings. The goal i…

This study looks at whether emergency medical services (EMS) can safely start buprenorphine treatment for people with opioid use disorder right at the scene of an emergency. Researchers will first test how practical and acceptable this approach is, then track whether patients sta…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study tests a smoking cessation program that combines a smartphone app with support from a psychologist. 429 adult smokers who want to quit will be placed into one of three groups: eight sessions with a psychologist plus the app, four sessions plus the app, or the app alone.…

This study tests whether cannabidiol (CBD) can reduce the need for strong painkillers (opioids) in people with end-stage prostate cancer that has spread and no longer responds to standard treatments. About 58 participants will receive either CBD or a placebo three times daily for…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests a mindfulness program designed to help sexual assault survivors reduce alcohol misuse and tobacco use. Researchers will enroll 120 college students aged 18-24 who have experienced sexual violence and drank alcohol recently. Participants will take online surveys a…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study aims to help Native Hawaiian adults quit smoking by testing nicotine gum, group counseling, or both. About 75 participants from public housing sites on O'ahu will be assigned to one of three groups. Researchers will check which method works best for quitting and is mos…

This study is for pregnant people who use tobacco and cannabis and want to quit. Researchers will test a program that helps with depressive symptoms to make quitting easier. The study involves 25 participants and will measure how well the program works and if people stick with it…

This study tests whether daily motivational text messages can help people in rural Mississippi quit smoking or smokeless tobacco. Researchers will recruit 150 tobacco users who want to quit and have tried before. Half will get encouraging texts, the other half non-specific messag…

This early-phase trial tests whether combining lidocaine and ketamine can reduce severe cancer-related pain that doesn't respond to opioids. Twenty-four adults will receive two weekly infusions of the drug combination or an active placebo in a blinded, crossover design. The goal …

This pilot study tests whether adding music therapy to nicotine replacement therapy (patches and gum) helps healthcare professionals reduce smoking cravings more than nicotine therapy alone. 80 participants will be split into two groups and followed for 3 months. The study also l…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study tests whether a virtual reality app, used alongside standard counseling, can help people stop vaping nicotine. Ninety participants aged 16 and older who vape at least weekly and want to quit will use the VR app at home for 12 weeks. The app is designed to make practici…

This study tests whether adding a structured exercise program to cognitive-behavioral therapy (CBT) helps smokers quit more effectively than CBT alone or general health advice. Sixty-six adult smokers will be randomly assigned to one of three groups and followed for 12 weeks. Res…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This study tests whether a special breathing technique called Wim Hof breathing can improve lung function in young men who smoke e-cigarettes. Forty-two participants will practice deep breathing and breath-holding exercises. Researchers will measure lung capacity, oxygen levels, …

This study will test whether cannabis can reduce the desire to take opioids in people with opioid use disorder. Thirty participants will live in a hospital for six weeks and receive either cannabis or a placebo, along with opioids. Researchers will measure how many times particip…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study looks at whether adding alcohol-related smells to virtual reality scenes makes people with alcohol use disorder feel stronger cravings. Sixty participants will experience different combinations of visual scenes (neutral or alcohol-related) and smells (none or alcohol).…

This study looks at how using nicotine vapes before or after THC vapes changes the amount of THC that enters the bloodstream. Researchers will compare THC levels and effects in 60 adults who regularly use both products. The goal is to understand safety and how these products work…

This study will test 35 people with known or suspected allergies to cannabis, tree nuts, or seeds to see if they are also allergic to hemp seeds. Participants will receive skin prick tests and blood tests to measure allergic reactions. The goal is to understand the potential alle…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study is the first time MG001, a formulation of mitragynine from the kratom plant, is being tested in people. Researchers want to see if it is safe and how the body processes it. About 32 healthy adults who have used oral opioids recently will receive a single dose of MG001 …

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study will test whether a mobile app that teaches people about how addiction affects the brain is easy to use and acceptable for people receiving medication treatment for opioid or stimulant use disorders. Forty participants will use the app and complete surveys. The goal is…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study looks at whether new types of menthol cigarettes are more addictive than a person's usual menthol brand. About 48 daily smokers will test different cigarettes in a lab and at home. Researchers will measure nicotine levels in the blood and ask about how much participant…

This study looks at how a moderate dose of THC (the active part of cannabis) affects mood, stress, and thinking in people who use cannabis at least once a week. Ninety adults will take part in two sessions—one with active cannabis and one with a placebo—without knowing which they…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will check how addictive two new nicotine pouches are by measuring their effects on the body and how much nicotine gets into the blood. About 40 healthy adults who smoke and also use smokeless tobacco will try the pouches in a clinic. The goal is to understand the abus…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers will use the toolkit during routine care to see if it…

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This pilot study tests whether a specially designed family therapy program is practical and well-liked by women who have opioid use disorder and are involved in the justice system. About 120 women and a family member will take part, with some receiving the therapy plus usual care…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will compare how synthetic nicotine and a nicotine analogue (6-methylnicotine) behave in the body versus traditional tobacco-derived nicotine. Twenty-four regular vapers will vape e-liquids containing these substances, and researchers will measure their levels in the b…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study tests a new care system for people with opioid use disorder across the University of Illinois Hospital and Clinics. Researchers want to see if it increases screening, helps patients stay in care, boosts use of addiction medications, and reduces opioid-related deaths. O…

This pilot study will test whether it is possible to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions over 6 months, or receive guidance on finding a…

This study tests whether a tool called Compl-AI can predict which adults with opioid use disorder will stop their medication early. Researchers will observe 295 people receiving standard care and track their treatment attendance and adherence. The goal is to see if the model work…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study will examine 212 regular smokers to see how their level of nicotine addiction relates to breathing strength, physical fitness, memory, pain, sleep, and overall well-being. Participants will answer questionnaires and perform simple tests like a 6-minute walk. No treatme…

This study will follow 120 people with schizophrenia who use cannabis, using mobile phone surveys and thinking tasks to track symptoms in real time. The goal is to understand how cannabis may both worsen positive symptoms (like hallucinations) and reduce negative symptoms (like l…

This study will test a new visual scale designed to help people who use methamphetamine estimate how much they use each day. Researchers will compare the scale's results with hair samples and other methods to see if it is accurate and easy to use. About 100 people aged 20-40 who …

This study looks at whether cannabidiol (CBD) can reduce the amount of THC heavy cannabis users need to feel intoxicated. About 30 adults who use cannabis heavily will take a single dose of CBD or a placebo, then inhale THC using a vaporiser and decide when they've had enough. Re…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study tests a program to help mental health providers prescribe smoking cessation medications to veterans with serious mental illness. Researchers will work with 65 providers and veterans to see if the program is acceptable and practical. The goal is to overcome barriers tha…

This study tests whether a coaching program called COSTARS helps child welfare supervisors better support their teams, including caseworkers and peer mentors with lived recovery experience. About 200 supervisors in Ohio's START program will either receive coaching or continue usu…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study tests whether a brief education session about cannabis risks can increase knowledge and motivation to reduce use among people with eating disorders. 80 patients will receive either cannabis education or sleep hygiene education during their first week of a 20-week eatin…

This study looks at how different amounts of oral THC (the main psychoactive ingredient in cannabis) affect mood, heart rate, and drug feelings in healthy adults who have used cannabis before. Participants will take either a low, medium, or high dose of THC or a placebo during fo…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study looks at whether a 50-minute education session can help pregnant and new mothers taking medication for opioid use disorder, along with a friend or family member, learn more about their treatment and newborn withdrawal. Researchers will measure how many women are intere…

This study will enroll 70 adult smokers to compare how appealing and addictive different e-cigarettes are versus their usual cigarettes and nicotine gum. Participants will try each product in a random order during an 8-day stay at a clinic. Researchers will measure how much nicot…

This study will measure how much nicotine enters the bloodstream when adult smokers use eight different e-cigarette products with various flavors (menthol, mint, tobacco, fruit). Forty healthy smokers, aged 21 to 60, will try each product in a random order while staying at a clin…

This study will test if simple, bedside heart tests (ultrasound, EKG, and blood tests) can accurately detect heart problems in pregnant women who regularly use methamphetamine. Researchers will compare these quick tests to a full heart ultrasound. The goal is to find a faster, ea…

This study looks at how stress and brain stimulation affect thinking and opioid cravings in 20 people with opioid use disorder who are not seeking treatment. Participants will receive either real or fake brain stimulation (rTMS) and a stress-inducing drug or placebo. Researchers …

This study will give 80 healthy adults who use cannabis occasionally different low doses of inhaled CBD (5 to 100 mg) or a placebo to see if they feel a pleasant effect. Each person will try all doses in a random order, and researchers will also explore if current tools miss any …

This pilot study will test whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to improve access to HIV prevention (PrEP), hepatitis C treatment, and medication for opioid use disorder. The st…

This study will enroll 40 healthy adult smokers to compare how much they crave different tobacco products. Participants will try heated tobacco devices, their usual cigarettes, and nicotine gum in a clinic setting. Researchers will measure their desire to smoke and nicotine level…

This study will monitor 52 adults after surgery to see if the timing of opioid painkillers affects breathing problems. Participants will wear a noninvasive breathing monitor in the recovery room. The goal is to find a link between when opioids are given and drops in breathing fun…

This study aims to develop and test a program that helps people receiving medication for opioid use disorder connect with recovery community centers. Researchers will enroll 145 adults in Massachusetts who are on buprenorphine treatment. The goal is to see if this program is feas…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study will enroll 16,000 people invited to colorectal cancer screening in Norway. Participants will fill out a diet and lifestyle questionnaire and receive personalized digital feedback on how their habits compare to health recommendations. Some groups get extra support like…