CERVICAL CANCER

This study is testing two experimental drugs, BL-B01D1 and SI-B003, to see if they can help control advanced cervical and other gynecological cancers that have returned or spread. Researchers will give the drugs separately and together to about 130 patients to find the most effec…

This is a first-in-human study testing a new oral drug called NX-1607 in adults with advanced cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body handles the drug, both alone and combined with a common chemot…

This study is testing whether using artificial intelligence (AI) to adjust daily radiation treatments, combined with weekly MRI scans, can reduce bowel and bladder side effects for people with cervical cancer. The research involves 40 participants receiving standard chemoradiatio…

This study is testing a specialized type of radiation therapy called proton beam radiation for women who have had surgery for cervical or uterine cancer. The main goal is to see how often this treatment causes serious stomach and bowel side effects. Researchers will also track wh…

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This is a first-in-human study testing a new experimental drug called 212Pb-DOTAM-GRPR1 in adults with advanced cancers that have returned or spread. The main goal is to find a safe and tolerable dose. Researchers will also check if the drug, which delivers radiation directly to …

This study is testing a more precise type of radiation therapy for cervical cancer. It compares a new 'online adaptive' method, which adjusts treatment in real-time, against standard radiation to see if it causes fewer side effects and better controls the tumor. The trial will in…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This study is testing whether combining two newer drugs, sacituzumab tirumotecan and QL1706, can help control advanced cervical cancer that has returned or spread after standard chemotherapy. It will enroll about 89 women to see how well the combination shrinks tumors and how saf…

This study is testing a specialized radiation technique for patients with cervical cancer or pelvic recurrences who cannot receive standard internal radiation (brachytherapy). The goal is to see if this method can control the cancer in the treated area while limiting damage to ne…

This study is testing a shorter, more intense radiation schedule combined with chemotherapy for cervical cancer. The goal is to complete treatment in less time than the standard 7-8 weeks while aiming for similar effectiveness and safety. Researchers will measure tumor shrinkage,…

This early-stage study is testing whether an experimental drug called NRM-823 is safe and can help control advanced cancers that have stopped responding to standard treatments. Researchers will give NRM-823 alone and combined with immunotherapy to about 150 adults with various so…

This study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced cervical cancer that has worsened after standard treatment. It will involve about 35 women to see if the combination shrinks tumors and for how long. The goal is to…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing whether adding an immunotherapy drug (camrelizumab) to standard chemotherapy helps prevent cervical cancer from returning after surgery, specifically for patients whose cancer had spread to their lymph nodes. It will follow 59 participants for three years to…

This study is testing whether using MRI scans instead of CT scans to guide radiation therapy for gynecologic cancers can reduce side effects and improve treatment accuracy. Researchers at Johns Hopkins will compare how well MRI helps doctors target tumors while sparing healthy or…

This study is testing a new experimental drug called CNSI-Fe, which is an iron-loaded nanoparticle suspension injected directly into tumors. The goal is to see if it is safe and can help control cancer in people with advanced solid tumors that have stopped responding to standard …

This study is testing a new drug called volrustomig, both by itself and combined with chemotherapy, for people with advanced solid tumors that have spread. It is enrolling about 257 adults with specific advanced cancers, including cervical, head and neck, esophageal, and a type o…

This is a very early study to check the safety and find the right dose of a new injection called TI-0093. It is for people with advanced head, neck, or cervical cancers linked to HPV-16 that have come back or spread after standard treatments. The main goals are to see what side e…

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This early-stage trial is testing a new radioactive drug called 177LuBetaBart in adults with advanced solid cancers that have stopped responding to standard treatments. The study aims to find a safe dose and see if the drug shows early signs of fighting tumors. Participants will …

This study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced cervical cancer that has returned or spread. It is for women whose cancer has continued to grow despite previous treatments, including other immunotherapies. The ma…

This large Phase 3 trial is testing whether a new drug called MK-2870 (sacituzumab tirumotecan) works better than current standard treatments for women whose cervical cancer has returned or spread after their first round of chemotherapy. The study will involve about 686 participa…

This early-stage study is testing a new treatment called KD01, which is a specially engineered virus designed to infect and kill cancer cells. It is being given as a direct injection to women with cervical or endometrial cancer who have not responded to other treatments. The main…

This study is testing whether it is safe to combine a new targeted drug called tarlatamab with standard radiation therapy. It is for adults with advanced cancers that have a specific protein called DLL3, including certain lung cancers, melanoma, and others. The main goal is to se…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This study is testing an experimental drug called sacituzumab govitecan for women whose cervical cancer has returned or persisted after prior chemotherapy. The drug is designed to deliver chemotherapy directly to cancer cells. Researchers will measure if tumors shrink, how long p…

This study is testing an experimental drug called HLX43 for women with advanced cervical or ovarian cancer that has returned or spread after standard first treatments didn't work or caused severe side effects. The Phase 2 trial will enroll about 130 participants to find the right…

This study is testing an experimental drug called YL202 in people with advanced solid tumors, including lung, colorectal, and cervical cancer, that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease, and to unders…

This study tests a new support program to help young people living with HIV in Zambia get cancer diagnosed earlier and stick with their treatment. It will train peers to offer counseling and education to overcome barriers to care. The goal is to reduce early deaths from cancers l…

This study is testing a new combination of drugs (BL-B01D1, pembrolizumab, and sometimes bevacizumab) for women with advanced cervical or endometrial cancer that has returned or spread. The goal is to see if this combination can shrink tumors and control the disease better than c…

This early-stage study is testing a new type of personalized immune cell therapy (CAR-T) for people with advanced solid tumors that have a specific marker called CD70. The main goals are to find a safe dose and see how the body handles the treatment. It is for adults with cancers…

This study is comparing two types of radiation therapy for advanced cervical cancer: proton therapy and traditional photon therapy. Researchers want to see if proton therapy causes less damage to important immune cells and leads to fewer side effects while still effectively contr…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This is an early-stage study to find a safe dose and see if a new drug combination can help the immune system fight advanced cancers. It will test the experimental drug ASTX660 together with the immunotherapy pembrolizumab in up to 61 adults with solid tumors that have stopped re…

This study is testing whether adding a targeted radiation boost directly to the tumor during standard radiation therapy helps shrink large cervical cancers more effectively. It involves about 17 patients with bulky tumors who will receive the boost during their 5-6 weeks of pelvi…

This study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …

This study is testing a new personalized treatment for advanced cancers caused by HPV. Doctors take a patient's own immune cells, modify them in a lab to better target the cancer, and infuse them back to try to shrink tumors before standard therapy like chemo or surgery. The goal…

This study is testing whether taking two oral drugs, VS-6766 and defactinib, together can help control recurrent gynecologic cancers like ovarian and cervical cancer. It is for women whose cancer has a specific genetic change and has come back or worsened after at least one prior…

This study is evaluating the safety and performance of the Medtronic Hugo robotic surgery system when used to perform hysterectomies. It will enroll about 70 adult women who need this surgery for various conditions, including fibroids, endometriosis, and certain cancers. The main…

This study is testing a new combination of two drugs, ZG005 and gecacitinib, for women with advanced cervical cancer that has spread or returned. The main goals are to find a safe dose and see if the treatment can shrink tumors. It will involve about 120 participants to gather in…

This study is for people with advanced cervical cancer that has returned or spread and is no longer responding to the immunotherapy drug pembrolizumab. It will test if adding a new investigational drug called PRGN-2009 to pembrolizumab is more effective and safe than continuing p…

This study is testing whether removing lymph nodes before standard treatment helps women with advanced cervical cancer live longer without their cancer getting worse. Researchers will compare two approaches: standard treatment alone versus surgery to remove lymph nodes followed b…

This study is testing a new gene therapy for people with advanced cancers caused by HPV. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack HPV-infected cancer cells, and then infuse them back into the patient. The goal is to see if thi…

This early-stage study is testing a new vaccine called PVX7 in patients with advanced cervical cancer who have already completed their main treatment. The main goals are to see if the vaccine is safe and if it can trigger an immune response against the cancer. Researchers will al…

This study aims to improve health for women living with HIV by making cervical cancer screening and treatment a standard part of their existing HIV care. It will test two different sets of support strategies in Nigeria to see which one works better to get more women screened and …

This study aims to better understand potential eye-related side effects in cervical cancer patients receiving TIVDAK treatment. Researchers will monitor 100 participants with recurrent or metastatic cervical cancer through regular eye exams before, during, and after their treatme…

This study is testing if adding more chemotherapy to a standard treatment plan improves outcomes for women with locally advanced cervical cancer. It will compare two groups: one receiving immunotherapy plus radiation, and another receiving extra chemotherapy cycles on top of that…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This study is testing a faster, one-visit approach to prevent cervical cancer in women living with HIV in the Dominican Republic. It compares the new method, which provides screening results and treatment on the same day, to the standard multi-visit process. The goal is to see if…

This study is testing whether a new immunotherapy drug called MGD019 can help control advanced cervical cancer that has spread or returned. It's for patients who haven't yet received chemotherapy for their advanced disease. Researchers will measure how well the drug controls the …

This study is testing a new drug called BMS-986340 to see if it is safe and can help control advanced cancers. It will be given alone or combined with two other cancer drugs to about 950 people whose cancers have grown despite standard treatments. The main goal is to find the rig…

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This large, late-stage trial is testing whether a new targeted drug (sacituzumab tirumotecan) combined with two existing cancer drugs works better than standard care for advanced cervical cancer that has spread. The study aims to see if this combination helps patients live longer…

This study is testing a new drug called TER-2013 in people with advanced solid tumors that have specific genetic changes. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients who have run out of standard treatment options.

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing whether a new drug called ivonescimab can help control advanced endometrial or cervical cancer that has continued to grow despite previous treatment. The drug works by targeting two different pathways that cancer cells use to grow and evade the immune system…

This study is testing whether a cold plasma treatment can clear HPV infections in women. Researchers will treat 50 women with confirmed HPV infections and monitor whether the virus is eliminated. The study also aims to understand how the treatment affects cervical cells and tissu…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This study is testing whether a special light-scanning technology can help doctors better identify cervical cancer during routine exams. Researchers will use the device on 350 women who are already scheduled for cervical cancer screening or follow-up procedures. The goal is to se…

This study aims to develop a new test to detect endometrial, ovarian, and cervical cancers. Researchers are looking for chemical markers in vaginal fluid and blood samples from over 3,000 women. The goal is to create a less invasive way to find these cancers earlier, when they ar…

This study aims to find the best dose and storage method for a special green dye (Indocyanine Green) used during surgery for uterine, cervical, or vulvar cancer. The dye helps surgeons see and test the first lymph nodes where cancer might spread. Researchers will test different a…

This study is testing whether a newer type of scan (PET/MRI) is better than the current standard scan (PET/CT) at finding if cervical cancer has spread to lymph nodes. Researchers will compare both scans in 50 patients with locally advanced cervical cancer. The goal is to see if …

This study is testing a new blood test to detect and monitor HPV-related cervical cancers and pre-cancers. It aims to see if the test can distinguish between early pre-cancerous changes and invasive cancer. If successful, it could offer a less invasive alternative to current scre…

This study is testing whether a new device called 'Calla' could replace the traditional speculum during routine cervical cancer screening (Pap smears). Researchers want to see if patients find the Calla device more comfortable and easier to use than the standard speculum. Some pa…

This study is testing a portable, AI-powered camera called the Pocket Colposcope to improve cervical cancer screening for women who test positive for HPV. It aims to help doctors in clinics quickly and accurately identify pre-cancerous changes, so women can get the right treatmen…

This study aims to test new, potentially faster and simpler methods for detecting cervical cancer and pre-cancer in women in Mozambique. It will enroll 678 women who have already received a positive result from a standard screening test. Researchers will compare the accuracy of a…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing whether two different at-home HPV self-collection kits are a good alternative to a doctor's Pap smear for cervical cancer screening. It focuses on helping minority women aged 25-65 who have fallen behind on their screenings, often due to barriers like langua…

This study is testing a new, all-in-one system designed to make cervical cancer screening simpler and more accessible in low-resource countries. It uses artificial intelligence (AI) to analyze a urine sample for signs of the virus that causes cervical cancer. For women who test p…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing whether a simple, at-home self-sampling kit for HPV (the virus that causes cervical cancer) can provide effective screening for women in Ukraine during the ongoing war. It aims to offer 1,000 women aged 30-60 a convenient way to get tested when regular clini…

This study is testing a comprehensive support program designed to prevent cervical cancer in women in India who have both HPV and HIV. The program provides group education, one-on-one support from a community health worker, nutritional guidance, and food supplements. Researchers …

This study is testing whether sending at-home HPV self-sampling kits can help more women get screened for cervical cancer. It will enroll 15,000 women in the Czech Republic who have not had a recent screening. Researchers will compare different ways of offering the kits—by mail, …

This study is testing a mobile phone app called mSaada, designed to help community health volunteers in Kenya find and screen more women for cervical cancer. The goal is to see if the app helps more women get screened, understand their risk, and receive treatment if they test pos…

This study tests a coordinated care program designed to help more women in Kenya get screened for cervical cancer and receive timely follow-up care if needed. The program involves care coordinators who support clinic staff and use a mobile health platform to track patients. Resea…

This study is testing a new way to combine cervical cancer screening with family planning services in Mozambique. It aims to see if offering these services together makes it easier for women to access both types of care. The research will involve about 14,600 women aged 30-49 or …

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing if using the Headspace mindfulness app can help women with endometrial or cervical cancer feel less stressed and have a better quality of life during their cancer treatment. Researchers want to see if practicing mindfulness with the app can also help reduce …

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This study aims to find out if a much shorter, one-week course of radiation therapy works as well as the standard 6-8 week course for relieving pain and other symptoms in patients with advanced cervical cancer who cannot have curative treatment. It will involve 230 patients with …

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study aims to find out if a blood test for HPV and a special PET scan can better detect leftover cervical cancer cells after a patient finishes standard treatment. It involves 64 women with cervical cancer who are receiving standard chemotherapy and radiation. The goal is to…

This study aims to see if tracking changes in a common inflammation marker (CRP) in the blood can predict how well patients with advanced gynecologic cancers respond to immunotherapy. It will involve 120 women already scheduled to receive standard immunotherapy and chemotherapy. …

This study is testing two different blood tests to see if they can accurately measure how well a patient's cervical cancer is responding to treatments like surgery, radiation, or chemotherapy. Researchers will check if levels of HPV-related genetic material in the blood go down w…

This study aims to collect and store tumor tissue and blood samples from patients with certain cancers. The goal is to better understand the relationship between a tumor's genetic makeup, its surrounding environment, and the body's immune response. Patients will receive standard …

This study aims to understand how different cancers interact with the body's immune system, particularly focusing on immune cells called T cells. Researchers will collect tissue and blood samples from 1,100 patients with seven types of solid tumors over five years. The goal is to…

This study is testing a blood test to see if it can detect HPV virus DNA in people with anal or cervical cancer before, during, and after they receive standard radiation treatment. Researchers want to learn if the results of this blood test can help predict whether the cancer mig…

This early-stage study aims to understand the safety and imaging properties of an experimental radioactive tracer called RAD301. The research involves 9 participants, including both healthy volunteers and people with specific cancers like pancreatic, lung, or ovarian cancer. Part…

This study is testing whether simple 'liquid biopsies'—like blood tests, mouth rinses, and swabs—can help doctors monitor patients after treatment for HPV-related cancers. Researchers want to see if these tests can detect signs that the cancer might be returning much earlier than…

This study aims to learn how radiation therapy changes the environment inside and around tumors in cervical and pancreatic cancer. Researchers will collect tissue samples, blood, and imaging data from 60 patients before, during, and after their standard radiation and chemotherapy…