CERVICAL CANCER

This study tests a drug called AK104 (cadonilimab) in 18 adults with a rare and fast-growing type of cervical cancer that has come back or spread. The goal is to see if the drug can stop the cancer from growing for at least 6 months. Participants must have already tried standard …

This early-phase study tests a new drug called IMGN151 in 256 adults with recurrent gynaecological cancers (ovarian, endometrial, cervical, and related cancers). The drug is designed to target and kill cancer cells while sparing healthy ones. The main goals are to check safety, f…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors (like ovarian, breast, prostate, and lung cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and tolerable when given alon…

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 1,410 participants will receive t…

This study tests a new drug called Q702 combined with pembrolizumab (a standard immunotherapy) in people with advanced esophageal, stomach, liver, or cervical cancer that has worsened after prior treatment. The goal is to see if the combination is safe and can shrink tumors or sl…

This study tests whether combining two drugs, dostarlimab and cobolimab, can shrink tumors or slow the disease in people with advanced or recurrent cervical cancer. About 66 participants with measurable tumors will receive the combination. The main goal is to see how many patient…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded well to standard treatments. The goal is to find a safe dose and see if the combo can shrink tum…

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This trial tests a new antibody drug called acasunlimab (GEN1046) in people with advanced solid tumors that have stopped responding to standard treatments. The study has two parts: first, to find safe doses, and second, to see how well the drug works alone or combined with other …

This study is for people with advanced solid tumors (like lung, bladder, or skin cancer) whose disease has progressed after standard immunotherapy. It tests a new drug combination designed to boost the immune system to fight cancer. About 40 participants will receive the experime…

This study tested whether adding a precise type of radiation (SBRT) to an immunotherapy drug (atezolizumab) could shrink tumors better than the drug alone in people with cervical cancer that has come back or spread. The trial enrolled 21 adults with recurrent, persistent, or meta…

This early-phase study tests the safety of a new drug called AB598, given alone or with other treatments, in about 40 people with advanced solid tumors (e.g., lung, bladder, breast, or ovarian cancer). The main goal is to see if the drug is safe and tolerable. Participants must h…

This study tests whether a mix of three immunotherapy drugs can shrink tumors in people with advanced HPV-related cancers that have spread or not responded to standard treatments. About 51 adults with cancers like cervical, anal, or throat cancer will receive the drugs for up to …

This study tests a combination of two drugs (zimberelimab and lenvatinib) in 30 people with advanced cervical cancer that got worse after prior immunotherapy. The goal is to see if this combo can shrink tumors or slow the disease. Participants must have tried platinum-based chemo…

This study tests whether a combination of two drugs (camrelizumab and famitinib) works better than standard chemotherapy for women with cervical cancer that has returned or spread and cannot be cured by surgery or radiation. About 443 women aged 18-75 who have not had prior treat…

This early-phase study tests a new treatment called T-Plex for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and attack multiple cancer-related targets. Th…

This study tests an HPV vaccine (PRGN-2009) alone or combined with a drug called M7824 in adults with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system's attack on tumors. Participants…

This early-phase study tests a new drug, AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment for people with advanced solid tumors that have stopped responding to standard therapies. The main goal is to find the safest dose and check for…

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia, currently…

This phase 3 trial tests whether adding the drug AK104 to standard chemotherapy (with or without bevacizumab) helps people with advanced cervical cancer live longer without their disease getting worse. About 445 women whose cancer has spread or returned and cannot be cured by sur…

This early-phase study tests an experimental drug called RNDO-564, alone or with pembrolizumab, in adults with advanced solid tumors (like bladder, lung, or breast cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the best dose,…

This early-phase study tests a new drug called LY4101174 in people with advanced or metastatic solid tumors, including bladder, breast, lung, and other cancers. The goal is to find a safe and effective dose and see if the drug can shrink tumors. About 490 participants will take p…

This study tests an experimental drug called HFB200301, alone or with another drug (tislelizumab), in adults with advanced solid tumors like stomach, kidney, or lung cancer. The main goal is to find safe doses and check for side effects. About 72 people will take part, and the st…

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can better show which pelvic lymph nodes contain cancer in women with stage IB1 cervical cancer or high-grade endometrial cancer. About 42 women scheduled for surgery…

This study explores whether a non-invasive electroacupuncture technique can detect persistent viruses like HPV and SARS-CoV-2 in 30 women with advanced cervical cancer. Researchers will measure electrical responses at specific acupuncture points to see if they match viral presenc…

This study looks at whether mailing self-sampling kits for HPV testing can help more Asian and Asian American women get screened for cervical cancer. Many women find it hard to go to a clinic for a Pap test, so this approach offers a convenient at-home option. The study involves …

This study looks at whether giving women a free self-sampling device (SSD) through their general practitioner can increase cervical cancer screening rates. It includes women aged 31-64 who haven't had a smear test in the last 6 years. The goal is to see if offering the SSD in per…

This study looks at better ways to help women in Kenya get screened for breast and cervical cancer. Many women are diagnosed late, so the goal is to find cancer early when treatment works best. About 5,400 women aged 30-55 will take part, and researchers will compare different st…

This study tests a program called Game Changers for Cervical Cancer Prevention in Uganda. It involves 1,400 women who have already been screened for cervical cancer. These women are trained to encourage their female friends and family members who have never been screened to get t…

This large Phase 3 trial is testing a new 9-valent HPV vaccine designed to protect against nine types of human papillomavirus. It aims to prevent cervical cancer, precancerous lesions, and genital warts in healthy women aged 18 to 45. The study compares the new vaccine's effectiv…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study looks at whether teaching women with cervical cancer about healthy habits can improve their quality of life, physical activity, self-esteem, and mood. About 28 women will be split into two groups: one gets health education through meetings and social media for 12 weeks…

This study tests whether adding a special yoga and physiotherapy program to standard care can lower stress in women undergoing brachytherapy for cervical cancer. About 98 women will take part, and their stress levels will be measured 15 days after treatment starts. The program is…

This study uses special PET and MRI scans to measure oxygen levels, blood flow, and metabolism in brain and cervical tumors. About 20 adults with high-grade glioma or cervical cancer will undergo these scans before starting their standard treatment. The goal is to learn how tumor…

This study aimed to compare the standard Pap smear with a new blood test that looks for three proteins to see which is better at finding early cervical cell changes. It was open to healthy adults aged 18-85. However, the study was withdrawn before any participants were enrolled, …

This study looks at how well different two-step screening methods work to find cervical cancer early in Botswana. About 3,000 women aged 25 and older will take part. Researchers will compare HPV testing followed by visual exams or genotype checks to see which combination is most …

This study surveys 300 transgender men in France aged 25-65 who still have a cervix to understand why many skip cervical cancer screening. It aims to identify barriers like discrimination and lack of knowledgeable healthcare providers, as well as factors that help. The goal is to…

This study aims to measure oxygen levels inside cervical cancer tumors during a standard treatment called brachytherapy. About 10 adults with cervical cancer will have a tiny sensor placed in their tumor to record oxygen. The goal is to learn how oxygen levels relate to treatment…

This study looks at how well women with cervical cancer finish their treatment and how many side effects they have, comparing those who also have HIV to those who do not. About 180 women in India with advanced cervical cancer will be followed during their standard treatment. The …

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with cancer symptoms or at risk will take part. Half the communities get the prog…

This study is a community-based program in Kenya that aims to improve cervical cancer prevention by screening adult women for HPV and vaccinating young girls. Researchers will enroll 300 more women and girls to learn how well self-collected HPV tests work compared to standard vis…

This study looks at how low oxygen levels (hypoxia) and fluid pressure inside cervical cancer tumors affect how well radiation therapy works. Researchers will measure these factors in 500 patients before and during treatment. The goal is to find the best way to identify which pat…

This study was designed to see if a mobile health app helps patients with recurrent head and neck or gynecologic cancers track their symptoms and quality of life. Researchers planned to ask patients about their experience using the app and whether they found it easy and useful. T…

This study tests a web-based system called CATSystem that helps doctors follow guidelines for cervical cancer screening and treatment. About 6600 women at 10 Kenyan hospitals will take part. The goal is to see if the tool increases the number of women who get proper care after a …

This study looks at whether it's possible and acceptable to offer HPV testing and immediate treatment for pre-cancerous cervical lesions together in existing health clinics in Burkina Faso, Côte d'Ivoire, Guatemala, and the Philippines. Over 17,600 women will take part. The goal …

This study tests a program to improve health knowledge for women about to leave jail. It focuses on cervical and breast cancer, STDs, and birth control. About 279 women will take part to see if the program helps them understand and prevent these health issues.

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers and tumor features. The goal is to find who might qualify for future experimental T-cell therapies that target specific cancer antigens. …