New drug duo takes on multiple cancers in Mid-Stage trial

NCT ID NCT05642780

Ongoing Disease control Sponsor: Klus Pharma Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study is testing a combination of two drugs, SKB264 and pembrolizumab (Keytruda), in 240 people with certain advanced solid tumors, including cervical, urothelial, ovarian, prostate, and endometrial cancers. The goal is to see if the combination is safe and effective at shrinking tumors. Participants receive both drugs by IV infusion over 42-day cycles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SKB264 (a drug given by IV) plus pembrolizumab (Keytruda, an immunotherapy drug)
What this could lead to: If it works, this combination could offer a new treatment option for several hard-to-treat cancers.
What could go wrong: This is an early-phase (Phase 2) study with only 240 people, so results may not apply to everyone. Side effects from the drug combination are possible and not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma endometrial carcinoma metastatic prostate carcinoma ovarian cancer prostate cancer urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR

Contacts and locations

Locations

Affiliated Cancer Hospital of Guangxi Medical University

Nanning, Guangxi, China
Algemeen Ziekenhuis Klina

Brasschaat, Belgium
Anne Arundel Medical Center (AAMC)

Annapolis, Maryland, 21401, United States
BC Cancer - Kelowna

Kelowna, British Columbia, V1Y5L3, Canada
Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Beijing, China
Biokinetica S.A., Przychodnia Jozefow

Warsaw, Poland
Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Canada
Chongqing Cancer Hospital

Chongqing, China
Cliniques Universitaires Saint-Luc

Woluwe-Saint-Lambert, Belgium
Community Clinical Research Center

Anderson, Indiana, 46013, United States
Flinders Medical Centre

Bedford Park, Australia
Fudan University Shanghai Cancer Center

Shanghai, China
Grand Hôpital de Charleroi - Site Notre-Dame

Charleroi, Belgium
Henan Cancer Hospital

Zhengzhou, China
Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou Universit

Zhengzhou, China
Hubei Cancer Hospital

Wuhan, Hubei, China
Hunan Cancer Hospital

Changsha, Hunan, China
Hunan Cancer Hospital

Changsha, China
Icon Cancer Centre Wesley

Auchenflower, Queensland, 4066, Australia
Jilin Cancer Hospital

Changchun, Jinlin, China
Liaoning Cancer Hospital & Institute

Shenyang, China
Nanjing Drum Tower Hospital

Nanjing, China
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
Obstetrics and Gynecology Hospital Affiliated to Fudan University

Shanghai, China
Oncology & Hematology Associates of Southwest Virginia, Inc. Roanoke, VA

Roanoke, Virginia, 36274, United States
Peking University First Hospital

Beijing, China
Pratia MCM Krakow

Krakow, 30-510, Poland
Qilu Hosptial of Qlilu University

Jinan, China
Shandong Cancer Hospital

Jinan, China
Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China
Sun Yat-Sen University Cancer Center

Guangzhou, China
Sun Yat-sen Memorial Hospital

Guangzhou, China
Szpitale Pomorskie Sp. z o.o.

Gdynia, Poland
Texas Oncology, P.A. Amarillo, TX

Amarillo, Texas, 79103, United States
Texas Oncology, P.A. Austin, TX

Austin, Texas, 72007, United States
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, China
The First Affiliated Hospital of Jilin University

Changchun, China
The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China
The First Affiliated Hospital of Xi'an Jiaotong University

Xi’an, Shanxi, China
The Second Hospital of Dalian

Dalian, Liaoning, China
The first Affiliated Hospital of Zhengzhou University

Zhengzhou, China
UT Health East Texas - Hope Cancer Center Tyler

Tyler, Minnesota, 75702, United States
Union Hospital, Tongji Medical College,Huazhong University of Science and Technology

Wuhan, China
Weifang People's Hospital

Weifang, Shandong, China
Westchester Medical Center

Hawthorne, New York, 10532, United States
Wollongong Hospital

Kogarah, Australia
Zhejiang Provincial People's Hospital

Hangzhou, China
Zhongnan Hospital of Wuhan University

Wuhan, China

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