CERVICAL CANCER

This study tests a combination of three drugs (sacituzumab tirumotecan, iparomlimab, and tuvonralimab) given before surgery to people with locally advanced cervical cancer. The goal is to see if the drugs can completely eliminate the tumor before the operation. About 25 participa…

This study tests whether adding two experimental drugs (LB1410 and LB4330) to the standard drug lenvatinib works better than chemotherapy for people with advanced cervical cancer that has returned or spread. About 120 participants will be randomly assigned to one of the treatment…

This study tests whether combining two drugs, camrelizumab and famitinib, can help prevent cervical cancer from returning after surgery. About 30 adults with a specific type of cervical cancer that tests positive for PD-L1 will receive the treatment. The main goal is to see how m…

This study tests whether adding a drug called telaglenastat (CB-839) to standard chemoradiation can help people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III-IVA cervical cancer will receive the combination treatment. …

This study tests whether daily online adaptive radiotherapy (ART) can safely deliver fewer, stronger radiation doses for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to either standard radiation or the new adaptive approach…

This study tests a new drug called JSKN033 combined with standard chemotherapy, with or without another drug (bevacizumab), in people with advanced cervical cancer that has come back or spread. The goal is to see if the combination is safe and helps shrink or control tumors. Abou…

This phase 3 trial tests a new drug called SYS6002 against standard chemotherapy for people with advanced cervical cancer that has returned or spread after prior treatments. About 412 adults aged 18-75 will be randomly assigned to receive either SYS6002 or a chemotherapy chosen b…

This study tests a combination of two drugs—Utidelone and Toripalimab—in people with recurrent or metastatic cervical cancer that has progressed after standard chemotherapy. About 32 participants will receive both drugs intravenously in 21-day cycles. The goal is to see if the tr…

This study tests a new drug called PDS0101 in 27 adults with both HIV and HPV type 16. The goal is to see if it is safe and can boost the body's immune response against HPV, which can cause cancers like anal and cervical cancer. All participants will receive three doses of the dr…

This study tests a special microscope that takes high-quality pictures of cervical tissue samples right where the patient is seen. Researchers want to see if it can give doctors the same detailed information as standard lab tests, but much faster. About 400 women in Mozambique an…

This study tests a program that helps doctors improve cervical cancer screening and follow-up care. It will involve up to 80,000 patients in Boston, Florida, and Hawaii. The program combines education with quality improvement methods to make screening easier for both doctors and …

This study explores whether a text-message program and a mail-in HPV self-sampling kit can help women living with HIV who are overdue for cervical cancer screening get tested. Researchers will enroll 130 women and healthcare providers to see if the approach is feasible and accept…

This study compares two standard radiation methods—proton therapy and photon therapy—for women with newly diagnosed cervical or endometrial cancer. The goal is to see which causes fewer stomach and bowel side effects. About 116 participants will be randomly assigned to one of the…

This study looks at whether a program focused on sexual health and lifestyle can help women who have finished treatment for cervical cancer feel better about their sexual function and overall quality of life. About 120 women from hospitals in Spain will take part. Half will get t…

This study looks at whether hand and foot exercises can reduce nerve pain (like numbness and tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve their quality o…

This study looks at how to best screen for high-risk HPV in women living with HIV, who are more likely to get cervical cancer. Researchers will test a new method that gives more details about the type of HPV and how much virus is present. The goal is to see if this approach is pr…

This study aims to make cervical cancer screening easier for women with HIV in the United States. Researchers will talk to patients and doctors to find out what makes it hard to get screened and will test a self-testing option for HPV. The goal is to help more women get the care …

This study works with 80 women with HIV in South Africa who have had an abnormal Pap smear. Researchers will interview patients and providers to understand why some women miss follow-up appointments. Based on what they learn, they will create a support program and test if it help…

This study will test whether a face-to-face educational program can improve women's knowledge of cervical cancer and their attitudes toward the HPV vaccine. About 100 women aged 18-49 in Turkey will take part. Half will receive the education, and half will get usual care. Researc…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health and find the right follow-up care. The goal is to see if this program improves how confident and capable survi…

This study uses a special 3D ultrasound to look at blood flow in the cervix and ovaries of women with cervical cancer, precancerous changes, or ovarian cancer. Researchers want to see if blood flow patterns can help tell these conditions apart or predict how well patients will do…

This study will test a new blood test that looks for tiny bits of cancer DNA (called MRD) in 600 people with endometrial or cervical cancer. The goal is to see if this test can find cancer coming back earlier than current methods like CT scans. Participants will give blood sample…

This study will develop and test an AI system that helps doctors make better treatment decisions for cervical cancer in pregnant women. The AI will be compared to real doctor teams to see if it is accurate and fast. About 150 participants with cervical cancer and confirmed pregna…