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New shot aims to boost immunity against HPV in HIV patients

NCT ID NCT07090174

Not yet recruiting Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an immunotherapy called PDS0101 in 27 adults with both HIV and HPV 16. The goal is to see if it is safe and can strengthen the immune system's response against HPV, which can cause cancers like anal and cervical cancer. All participants will receive three doses of the vaccine, and researchers will monitor for side effects and immune changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PDS0101 (HPV 16-targeted immunotherapy with Versamune® adjuvant)
What this could lead to
If successful, this could point toward a way to help people with HIV clear HPV 16 infections and reduce their risk of HPV-related cancers.
What could go wrong
This is an early Phase 2 trial with only 27 participants, so results may not apply to everyone. The treatment may cause side effects like injection site reactions, and it is not yet known if it will effectively prevent cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS anal carcinoma anus neoplasm cervical cancer cervical squamous intraepithelial neoplasia HIV infectious disease human papilloma virus infection squamous cell intraepithelial neoplasia Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAL CANCER CERVICAL CANCER HIV (HUMAN IMMUNODEFICIENCY VIRUS) HPV 16 INFECTION HPV ASSOCIATED CANCERS

Contacts and locations

Locations

  • Montefiore Medical Center/Albert Einstein College of Medicine

    The Bronx, New York, 10461, United States

  • University of Puerto Rico

    San Juan, 00935, Puerto Rico

  • Weill Cornell Medical College

    New York, New York, 10010, United States

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