CERVICAL CANCER

This early-stage trial tested a new type of cell therapy for cancers caused by HPV, a common virus. Researchers gave patients specially engineered immune cells designed to find and attack cancer cells. The main goal was to find the safest and most effective dose of these cells, t…

This study tested a new three-drug combination (afuresertib, sintilimab, and chemotherapy) for people with advanced solid tumors that had stopped responding to prior immunotherapy. The goal was to find a safe, effective dose and see if this combination could help control cancer g…

This study aimed to see if robot-assisted surgery is better than standard minimally invasive surgery for women with cervical, uterine, or ovarian cancer. It directly compared the two techniques in 386 patients, focusing on recovery time, complications, and quality of life after s…

This study tested whether adding a new drug called tiragolumab to an existing immunotherapy (atezolizumab) was more effective and safe than using atezolizumab alone. It involved 172 women with advanced cervical cancer that had returned or spread and had stopped responding to prio…

This study looked at whether keeping the bladder empty or filled during cervical cancer radiation treatment affects how much radiation reaches nearby healthy organs. Researchers compared two approaches in 22 patients to see if one method better protects the bowel, rectum, and oth…

This study tested whether adding extra chemotherapy after the standard combination of chemotherapy and radiation could better prevent cancer from returning in patients with high-risk cervical cancer who had already undergone surgery. It involved 236 women who were randomly assign…

This first-in-human study tested a new oral drug called RP903 in people with advanced cancers that had stopped responding to standard treatments. The main goals were to find a safe dose and see how the body processes the drug. The study focused on specific cancers, including ovar…

This large study tested whether using detailed MRI scans to guide internal radiation (brachytherapy) is better than the standard method using X-rays for treating advanced cervical cancer. Over 1,000 patients with Stage IIB or IIIB cervical cancer were randomly assigned to receive…

This study aimed to find the best length of immunotherapy treatment for people with advanced cancers. It enrolled 161 patients whose cancer had remained stable after one year of treatment. Researchers randomly assigned participants to either stop their immunotherapy or continue i…

This study tested whether adding a special anti-cancer cream after standard surgery could better treat cervical precancer in women living with HIV. Researchers wanted to see if this two-step approach was practical and acceptable to 180 women in South Africa. The goal was to lower…

This study tested a type of internal radiation treatment called high-dose-rate brachytherapy for several cancers, including cervical, prostate, and breast cancer. Researchers placed temporary radiation sources directly into or near tumors to deliver a strong, focused dose. The ma…

This large, completed Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps women with advanced cervical cancer that has returned or spread. The study involved 617 women and aimed to see if the combination could help them live lon…

This study tested whether combining an immunotherapy drug (cemiplimab) with a vaccine (ISA101b) could help control advanced cervical cancer that had worsened after standard chemotherapy. It involved 113 adult patients whose cancer was caused by the HPV16 virus and had spread or r…

This large, completed Phase 3 trial tested whether a newer drug called tisotumab vedotin works better than standard chemotherapy for women with cervical cancer that has returned or spread after initial treatment. The study involved 502 participants who were randomly assigned to r…

This study tested if adding a targeted drug called cetuximab to the standard treatment of radiation and chemotherapy (cisplatin) was better for controlling cervical cancer. It involved 76 women with stage IB2, II, or IIIB cervical cancer who were not eligible for immediate surger…

This study tested the safety of adding a new immunotherapy drug called nivolumab to the standard treatment of radiation and chemotherapy for women with locally advanced cervical cancer. It involved 21 patients and aimed to see if this combination was safe and might be more effect…

This study tested whether a new type of HPV test, which can be done on a sample a woman collects herself at home, can accurately identify which women need to see a doctor for further checks. It enrolled 294 women aged 30-69 who were already scheduled for cervical screening. The g…

This study tested a systematic scoring system called the Swede score during colposcopy exams to see if it could improve the detection of serious cervical precancer (CIN2+). It involved 929 women in Denmark who were referred for a colposcopy due to an abnormal screening test. The …

This study tested a new device called the Femscope Calm Collect Device to see if it could make cervical cancer screening more comfortable and encourage more women to get tested. Researchers compared the new device to the traditional brush method in 13 adult women to see if it col…

This study tested a new program designed to increase cervical cancer screening for women living with HIV in Kenya. The program trained community health workers to provide education and support in a way that reduces the shame and fear often associated with HPV, HIV, and cancer. Re…

This study tested if mailing HPV self-test kits to women's homes could help more underserved women get screened for cervical cancer. Researchers compared three different outreach methods, including phone calls and mailed kits, to see which worked best. The goal was to find a prac…

This study tested whether a new survivorship clinic could help women manage symptoms and improve quality of life after completing treatment for early-stage breast or gynecologic cancer. Researchers enrolled 200 women who had finished their primary cancer therapy within the past y…

This small study tested whether a special exercise program before surgery could help women recover better after a hysterectomy for cervical cancer. Thirty-four women were split into two groups: one did a structured 4-week workout plan targeting pelvic strength and fitness before …

This study aimed to find the best way to prevent severe nausea and vomiting caused by a common chemotherapy regimen for gynecologic cancers like ovarian and cervical cancer. Researchers tested whether adding a drug called aprepitant to the standard two-drug anti-nausea treatment …

This study aimed to understand how many people develop leg swelling (lymphedema) after lymph node surgery for early-stage cervical or vulvar cancer. Researchers surveyed 111 patients who had this surgery between 2006 and 2022 to identify who might be at higher risk. The study onl…

This study examines how well the HPV vaccine protects against infections that can lead to cervical cancer over many years. Researchers followed 3,127 Rwandan women aged 18-28, including those living with and without HIV, to compare infection rates between vaccinated and unvaccina…

This study tested whether adding an educational video to the standard explanation helps patients with cervical or uterine cancer better understand and feel more comfortable with a specific type of internal radiation treatment called brachytherapy. Researchers compared two groups …

This study tested whether it is practical to use a PET scan on the first day of a specific radiation treatment (brachytherapy) for cervical cancer. It involved 14 patients who had already completed initial chemotherapy and radiation. The main goal was to see if the scan could be …