CERVICAL CANCER

This study looked at how well the HPV vaccine protects against cervical, anal, and oral infections in Rwandan women aged 18-28, both with and without HIV. Researchers measured infection rates and antibody levels years after vaccination. The goal is to confirm long-term protection…

This study tested whether using MRI scans to guide brachytherapy (a type of internal radiation) works better than the standard X-ray method for treating advanced cervical cancer. Over 1,000 women with stage IIB or IIIB cervical cancer took part. The goal was to see if MRI guidanc…

This early-phase study tested adding the immunotherapy drug nivolumab to standard chemoradiation for people with locally advanced cervical cancer. The main goal was to check safety and find the right dose, while also looking at how well the combination worked. 21 adults took part…

This early-stage trial tested a new treatment for people with HPV16-positive head and neck or cervical cancer that had spread or come back. The therapy uses a patient's own immune cells, specially trained to recognize and attack HPV-infected cancer cells. Some of these cells were…

This study tested a combination of two immunotherapy drugs (tiragolumab and atezolizumab) in 172 people with advanced or recurrent PD-L1-positive cervical cancer. The goal was to see if the combination could shrink tumors better than atezolizumab alone. The study found that some …

This study tested a combination of an immunotherapy drug (cemiplimab) and a vaccine (ISA101b) in 113 adults with advanced HPV16-positive cervical cancer that had worsened after standard chemotherapy. The goal was to see if the combination could shrink tumors or slow the disease. …

This study tested whether adding a targeted drug called cetuximab to standard radiation and chemotherapy (cisplatin) could help control cervical cancer better than standard treatment alone. It involved 76 patients with stage IB2 to IIIB cervical cancer that was not immediately op…

This study tested a combination of three drugs (afuresertib, sintilimab, and chemotherapy) in 22 adults with solid tumors like lung, cervical, or stomach cancer that had stopped responding to prior immunotherapy. The goal was to find the safest dose and see if the combo could shr…

This early-stage study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had no other treatment options. The main goal was to check the drug's safety and find the right dose, not to cure the cancer. While some pa…

This study looked at 236 women with high-risk early-stage cervical cancer who had already had surgery. All received chemotherapy and radiation, and half also got additional chemo afterward. The goal was to see if the extra chemo helped keep the cancer from coming back or improved…

This study tested a new drug called tisotumab vedotin against standard chemotherapy in 502 people with cervical cancer that had spread or returned. The goal was to see if the new drug helped people live longer. Participants were randomly assigned to receive either the new drug or…

This study tested a high-dose internal radiation method called brachytherapy in 43 people with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver the right dose. Participants received…

This study looked at whether adding an anti-cancer cream (5-fluorouracil) after surgery is an acceptable and useful treatment for cervical precancer in 180 women with HIV in South Africa. The goal was to see if women would stick with the treatment and find it acceptable. The stud…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps women with advanced cervical cancer live longer. Over 600 women whose cancer had spread or returned took part. The results showed that the combination improved survival, especiall…

This study tested whether a self-collected sample can accurately detect cervical cancer risk. Researchers compared a new DNA methylation test on self-collected samples versus doctor-collected samples from 294 women. The goal is to make screening easier and more accessible, especi…

This study tested a new scoring system to improve the diagnosis of cervical precancer in 929 women who had abnormal screening results. The goal was to see if the system could accurately identify precancer while safely reducing the number of unnecessary biopsies. The findings coul…

This study tested whether a new device called the Femscope Calm Collect Device can collect cervical cells for cancer screening with less pain than the traditional method. 13 healthy women aged 21-45 each had two exams to compare the devices. The goal is to make screening more com…

This study tested whether mailing HPV self-test kits to women who rarely or never get screened for cervical cancer could increase participation. Over 2,400 underserved minority women in Texas received either a mailed kit or usual care. The goal was to see if at-home testing makes…

This study tested whether a 4-week exercise program before surgery (prehabilitation) helps women with cervical cancer recover faster after a hysterectomy. 34 women participated, with half doing targeted exercises including pelvic floor training and the other half doing standard e…

This study looked at whether adding the drug aprepitant to the usual two anti-nausea medicines can better prevent nausea and vomiting caused by chemotherapy in people with gynecologic cancers like ovarian, cervical, and endometrial cancer. 143 patients took part. The goal was to …

This study tested whether using a vaginal dilator helps women who had brachytherapy for cervical cancer. 80 women were followed for 12 weeks and filled out surveys about sexual function, self-compassion, and quality of life. The goal was to see if this simple tool can ease side e…

This study tested whether a simple walking program, tracked with fitness trackers, could help people with various cancers (brain, head and neck, lung, gastrointestinal, or cervical) complete their planned chemoradiotherapy without missing treatments. 166 adults who could walk ind…

This study tested a new follow-up approach for people who finished treatment for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor every time, patients met with a nurse at every other visit and used a smartphone app to learn sel…

This study looked at whether adding a detailed educational video to the standard verbal consent process helps women with cervical or uterine cancer feel more satisfied and less anxious about brachytherapy, a type of internal radiation. About 80 women participated, and researchers…

This study tested whether using a PET-scan at the start of brachytherapy (a type of internal radiation) is practical for treating locally advanced cervical cancer. Fourteen women who had already received chemo-radiation took part. The main goal was to see if the PET-scan could he…

This study tested a program designed to reduce the stigma around cervical cancer and encourage more women to get screened. Researchers worked with 310 married women aged 30-60 in Nepal, comparing those who received the stigma-reduction program to those who did not. The goal was t…

This study tested a special clinic for women who finished treatment for early-stage breast or gynecologic cancer. The clinic used online surveys to track symptoms and connect patients with nurses or dietitians when needed. The goal was to see if this approach is practical and hel…

This study tested a new way to help women living with HIV get screened for HPV, a virus that can cause cervical cancer. The approach included simple scripts and videos to address fears and stigma. Over 980 women in Kenya took part, and researchers measured how many completed HPV …

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study looked at 386 women with cervical, uterine, or ovarian cancer to compare complication rates between standard keyhole surgery (laparoscopy) and robot-assisted keyhole surgery. The goal was to see which approach leads to fewer problems within the first six months after t…

This study followed over 1,700 women for up to 10 years to see if testing for the HPV virus alone is as safe and effective as using both an HPV test and a Pap test to screen for cervical cancer. Participants provided a cervical sample for both tests. The goal was to measure rates…

This study looked at 22 women with cervical cancer to see if keeping the bladder empty during a type of internal radiation therapy (brachytherapy) lowers the radiation dose to nearby organs like the bladder, rectum, and bowel. Each patient was scanned with both an empty and a ful…

This study collected information from 111 people who had surgery for early-stage cervical or vulvar cancer. Researchers used a questionnaire to find out how many developed lower leg swelling (lymphedema) after their lymph node procedure. The goal is to better identify who is at r…

This study looked at people with advanced solid tumors (like lung, bladder, or skin cancer) who had been on immunotherapy (PD-1/PD-L1 inhibitors) for one year and whose disease was stable. It randomly assigned them to either stop treatment or continue until their cancer got worse…

This study tested whether giving women a simple vaginal self-test kit to use at home would increase cervical cancer screening rates. Researchers recruited 656 women aged 50-65 in southern France who had not been screened in over three years. The goal was to see how many would acc…