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New hope for advanced cervical cancer: immune combo shows promise

NCT ID NCT04300647

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug combination (tiragolumab plus atezolizumab) against atezolizumab alone in 172 people with advanced or returning cervical cancer that has a specific marker (PD-L1-positive). The goal was to see if the combination could shrink tumors better. Participants received treatment until their cancer worsened or side effects became too severe. This is a disease control study, not a cure, as ongoing management is needed.

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Conditions

The condition(s) this trial relates to.

cervical cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

Locations

  • Arizona Oncology Associates

    Phoenix, Arizona, 85016, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Augusta University

    Augusta, Georgia, 30912, United States

  • Bialostockie Centrum Onkologi

    Bialystok, 15-027, Poland

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre Régional de Lutte Contre Le Cancer Val D'aurelle Paul Lamarque

    Montpellier, 34298, France

  • Centro Oncológico de Panamá

    Panama City, 0801, Panama

  • Chang Gung Medical Foundation, Linkou Branch

    Taoyuan City, 333, Taiwan

  • Chelyabisnk regional clinical center for oncology and nuclear medicine

    Chelyabinsk, Sverdlovsk Oblast, 454087, Russia

  • Christus Muguerza Clinica Vidriera

    Monterrey, Nuevo León, 64570, Mexico

  • Clinica CIMCA

    San José, 10103, Costa Rica

  • Clinica Ricardo Palma

    San Isidro, Lima 27, Peru

  • Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

    São Paulo, São Paulo, 01317-000, Brazil

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, 15006, Spain

  • Gangnam Severance Hospital

    Seoul, 06273, South Korea

  • Gustave Roussy

    Villejuif, 94800, France

  • Hospital Araujo Jorge

    Goiânia, Goiás, 74605-070, Brazil

  • Hospital Nossa Senhora da Conceicao

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Sao Rafael - HSR

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital de Caridade de Ijui

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • ICIMED Instituto de Investigación en Ciencias Médicas

    San José, 10108, Costa Rica

  • ICO - Site René Gauducheau

    Saint-Herblain, 44805, France

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Istituto Europeo Di Oncologia

    Milan, Lombardy, 20141, Italy

  • Istituto Tumori Napoli

    Naples, Campania, 80131, Italy

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Kaiser Permanente - Irvine

    Irvine, California, 92616, United States

  • Keimyung University Dongsan Hospital

    Daegu, 41931, South Korea

  • Korea Cancer Center Hospital of Korea Institute of Radiological and Medical Sciences

    Seoul, 01812, South Korea

  • London Regional Cancer Centre

    London, Ontario, N6A 4L6, Canada

  • MEDSI Clinical Hospital on Pyatnitsky Highway

    Moscow, Moscow Oblast, 143422, Russia

  • Mackay Memorial Hospital

    Taipei, Taiwan

  • Maharaj Nakorn Chiang Mai Hospital

    Muang, 50200, Thailand

  • Mater Misericordiae Limited

    South Brisbane, Queensland, 4101, Australia

  • McGill University Health Centre - Glen Site

    Montreal, Quebec, H4A 3J1, Canada

  • Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice

    Gliwice, 44-101, Poland

  • Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie

    Warsaw, 02-781, Poland

  • National Taiwan University Hospital

    Taipei, 110, Taiwan

  • Oncology Associates of Oregon, P.C

    Eugene, Oregon, 97401, United States

  • Policlinico Universitario Agostino Gemelli

    Rome, Lazio, 00168, Italy

  • Princess Margaret Cancer Center

    Toronto, Ontario, M5G 1Z5, Canada

  • Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic

    Kazan', Tatarstan Republic, 420029, Russia

  • Royal Victoria Regional Health Centre

    Barrie, Ontario, L4M 6M2, Canada

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarah Cannon Research Institute

    London, W1G 6AD, United Kingdom

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Szpital Morski im.PCK

    Gdynia, 81-519, Poland

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The Panama Clinic

    Panama City, 0832, Panama

  • Tomsk scientific research institute of oncology SO RAMN, PAD

    Tomsk, 634050, Russia

  • University College London Hospital

    London, NW1 - 2PG, United Kingdom

  • Volgograd Regional Clinical Oncology Dispensary

    Volgograd, 400138, Russia

  • Wielkopolskie Centrum Onkologii im. M. Sklodowskiej-Curie

    Poznan, 61-866, Poland

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