MRI-Guided radiation may improve cervical cancer treatment

NCT ID NCT03005743

Completed Disease control Sponsor: Tata Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large phase III trial tested whether using MRI scans to guide internal radiation (brachytherapy) works better than the traditional X-ray method for women with locally advanced cervical cancer. Over 1,000 participants received either MRI-based or X-ray-based brachytherapy. The goal was to see if MRI guidance improves tumor control and reduces severe side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (brachytherapy)
What this could lead to: If MRI-guided brachytherapy proves better, it could become the new standard for treating locally advanced cervical cancer, offering better tumor control and fewer long-term side effects.
What could go wrong: This trial is completed but results are not yet widely implemented. MRI-guided brachytherapy requires specialized equipment and training, so it may not be available everywhere. Also, individual results vary.

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Conditions

The condition(s) this trial relates to.

cervical cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

Locations

Tata Memorial Hospital

Mumbai, Maharashtra, 400012, India

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